Patents by Inventor Bruce J. Mayer

Bruce J. Mayer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of analysis and labeling of protein-protein interactions
    Patent number: 7846746
    Abstract: We have discovered a new method to analyze and characterize complex cell signaling networks. The method is based on specific binding of protein-protein interaction modules to a single type of protein or a mixture of proteins. The method utilizes a number of different protein-protein interaction domains as probes or sensors for the signaling state of the system under investigation.
    Type: Grant
    Filed: April 10, 2002
    Date of Patent: December 7, 2010
    Assignee: Children's Medical Center Corporation
    Inventors: Peter Nollau, Bruce J. Mayer
  • Coiled-coil mediated heterodimerization functional interaction trap
    Patent number: 6790624
    Abstract: Fusion proteins containing coiled-coil heterodimerization domains substituted for modular protein binding domains useful for validating functionally relevant protein-protein interactions, directing enzymes to specific substrates, and screening fusion libraries for functionally important interaction partners.
    Type: Grant
    Filed: March 24, 2001
    Date of Patent: September 14, 2004
    Assignee: The University of Connecticut
    Inventor: Bruce J. Mayer
  • Methods of analysis and labeling of protein-protein interactions
    Publication number: 20040157279
    Abstract: We have discovered a new method to analyze and characterize complex cell signaling networks. The method is based on specific binding of protein-protein interaction modules to a single type of protein or a mixture of proteins. The method utilizes a number of different protein-protein interaction domains as probes or sensors for the signaling state of the system under investigation.
    Type: Application
    Filed: March 18, 2004
    Publication date: August 12, 2004
    Inventors: Peter Nollau, Bruce J Mayer
  • Fusion protein and uses thereof
    Publication number: 20020151684
    Abstract: Two fusion proteins are described. One fusion protein comprises a protein having a modular protein domain, wherein the domain is replaced by a single chain antibody. The other fusion protein contains a binding site that binds to a modular protein binding domain, wherein a linear epitope in the binding site that binds to the domain is replaced by at least one copy of an epitope that binds to the single chain antibody. These fusion proteins, and nucleic acid encoding them can be used to screen for specific interaction between two proteins.
    Type: Application
    Filed: December 20, 2001
    Publication date: October 17, 2002
    Inventors: Bruce J. Mayer, Kalle Saksela, Tomas Kirchausen
  • Coiled-coil mediated heterodimerization functional interaction trap
    Publication number: 20020037999
    Abstract: Fusion proteins comprising coiled-coil heterodimerization domains substituted for modular protein binding domains useful for validating functionally relevant protein-protein interactions, directing enzymes to specific substrates, and screening fusion libraries for functionally important interaction partners.
    Type: Application
    Filed: March 24, 2001
    Publication date: March 28, 2002
    Inventor: Bruce J. Mayer