Abstract: A method and system is provided for monitoring the treatment of one or more patients with one or more medications. A medical treatment plan is defined as a set of data elements stored in a database and representative of a patient configuration file. The data elements are translated into a sequence of prompt and record events, which are communicated to one or more remote monitoring devices. Patient response data, supplied by the patients in response to the events and relating at least in part to a record of the intake of the medication by the patient, are obtained, recorded, and uploaded into the database. The patient response data are correlated with additional data relating to patient health or economic outcomes, for example using statistical analysis and data mining. The correlation can be used to adjust dosing recommendations to improve clinical outcome, reduce side-effects, and eliminate drug interactions.

Abstract: A method and system are presented for monitoring the performance of a clinical trial, and the adherence of trial participants to a protocol for the clinical trial. A plurality of templates are provided, which can be populated with protocol data can be entered that relate to behavioral elements of the protocol. The populated templates are downloaded to a plurality of remote devices. The remote devices generate, upon receipt of the templates populated with protocol data, prompting messages that prompt participants whether protocol elements have been performed, and that request performance data relating to any actual performance of the protocol elements. Based on the performance data, reports are periodically generated that compare actual performance of the protocol elements with expected or desired performance of the protocol elements.

Abstract: The present invention describes methods and apparatus useful in remotely modifying medical protocols by subgroups that are defined by specific database characteristics. In addition individual patient protocols may also be remotely modified. The method has application in medical databases containing the data collected by remote device monitoring of outpatients. These outpatients may be managed by one or more medical treatment or clinical research protocols or regimens involving pharmaceutical drugs, physiological data, educational content, and health status assessment or quality of life questionnaires. This method of mass customization of medical protocols, present in a medical database, is useful in efficiently monitoring and managing medical outpatients, through simultaneously instructing selected patient subgroups present in the database to make a change in their respective medical protocols.

Abstract: A medical monitoring device, operating system, and method is provided for managing administration of medical treatment regimens for treating a patient's medical conditions. The device stores medication schedule data, treatment data, patient query data, and patient response data. The device includes a controller for controlling modes of operation of the device, controlling access of the memory, controlling display of the treatment data and the patient query data on a display, receiving and processing patient response data, tracking timing, and providing scheduled medication alarm signals. The device provides scheduled medication alarm signals that alert the user concerning prescribed medications due to be taken. The device further includes removable trays of varying capacities that provide flexibility regarding type and quantity of dispersed medications.

Abstract: A medical monitoring device, operating system, and method is provided for managing administration of medical treatment regimens for treating a patient's medical conditions. The device stores medication schedule data, treatment data, patient query data, and patient response data. The device includes a controller for controlling modes of operation of the device, controlling access of the memory, controlling display of the treatment data and the patient query data on a display, receiving and processing patient response data, tracking timing, and providing scheduled medication alarm signals. The device further includes dedicated keys interfaced with the controller. Each dedicated key is associated with one of the medical treatment regimens, and initiates the display of treatment messages relating to the associated medical treatment regimen. Successive actuation of each dedicated key initiates the display of further treatment messages relating to the associated medical treatment regimen.

Abstract: A medical monitoring device, operating system, and method is provided for managing administration of medical treatment regimens for treating a patient's medical conditions. The device stores medication schedule data, treatment data, patient query data, and patient response data. The device includes a controller for controlling modes of operation of the device, controlling access of the memory, controlling display of the treatment data and the patient query data on a display, receiving and processing patient response data, tracking timing, and providing scheduled medication alarm signals. The device further includes dedicated keys interfaced with the controller. Each dedicated key is associated with one of the medical treatment regimens, and initiates the display of treatment messages relating to the associated medical treatment regimen. Successive actuation of each dedicated key initiates the display of further treatment messages relating to the associated medical treatment regimen.

Abstract: A device for monitoring medication of a patient and for prompting the patient into certain medication taking schedule and/or certain programming steps and routines. The device has a plurality of compartments, each of which may store medication, and an electrical signaling system to emit medication alert signals from time-to-time, each of which said signals indicates (a) that medication should be taken, (b) from which compartment the medication should be taken, (c) and the quantity of medication to be taken. If a designated compartment is not opened and closed within a predetermined period of time, the electrical signaling system will display an alarm and the event will be recorded as a missed medication event, unless the patient then opens the designated compartment. If each designated compartment is opened and closed, the take-medication signal and the alarm (if operating) are turned off and the event is recorded for later review.

Abstract: The present invention monitors the disease process and health of a patient undergoing drug treatment. A microprocessor-based medication dispenser provides for recording a variety of clinical information data; such as illness symptoms, side effects, general health ratings, adverse drug interactions, illness attitudes, and lifestyle habits at various times during a drug delivery cycle. The date and time of entry of the specific clinical information is entered, and correlated with the date and time when the patient has taken or missed a particular medication. The effects of the presumptive blood levels of one or more medications can then be assessed, as to their impact on the disease process, and any additional effects on the body. The device can analyze the data and display a response to it, or download the data into another device. The second device can analyze the data, and upload new information into the first device, to tell the patient to alter his or her behavior in taking medication.

Abstract: A device for monitoring medication of a patient and for prompting the patient into certain medication taking schedule and/or certain programming steps and routines. The device has a plurality of compartments, each of which may store medication and an electrical signaling system to emit medication alert signals from time-to-time, each of which the signals indicates (a) that medication should be taken, (b) from which compartment the medication should be taken, (c) and the quantity of medication to be taken. If a designated compartment is not opened and closed within a predetermined period of time, the electrical signaling system will sound an alarm. If each designated compartment is opened and closed, the take-medication signal and the alarm (if operating) are turned off and the event is recorded for later review. The device includes a display having a substantially continuous display area having portions thereof closely adjacent to each compartment.

Abstract: A container for medication has four compartments, each of which may store medication. An electrical signaling system emits take-medication signals from time to time, each of which said signals indicates (a) that medication should be taken, (b) from which compartment the medication should be taken, (c) the quantity of medication to be taken from the designated compartment, and instructions for taking the medication. If a designated compartment is not promptly opened and closed, the electrical signaling system will sound an alarm. If each designated compartment is opened and closed, the take-medication signal and the alarm (if operating) are turned off. A "night" switch is associated with each compartment and when manually operated turns off the signaling system for such compartment; however, the signaling system is automatically reactivated the next morning. A reload signal is given once a week, as a reminder to reload the compartments with medication.

Abstract: A device for indicating when medication should be taken has plural compartments, each of which may store medication. An electrical signaling system emits take-medication signals from time to time, each of which said signals indicates (a) that medication should be taken, (b) from which compartment the medication should be taken, (c) the quantity of medication to be taken from the designated compartment, and instructions for taking the medication. If a designated compartment is not promptly opened and closed, the electrical signaling system will sound an alarm. If each designated compartment is opened and closed, the take-medication signal and the alarm (if operating) are turned off. A reload signal is given once a week, as a reminder to reload the compartments with medication. The device has modular construction.