Patents by Inventor Bruce KenKnight

Bruce KenKnight has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11794015
    Abstract: A system includes a vagus nerve stimulation (VNS) device configured to deliver a vagus nerve stimulation signal having an ON-period status and an OFF-period status, and a processor and a non-transitory computer readable memory. The memory stores instructions that, when executed by the processor, cause the system to synchronously record a first ECG profile of during the ON-period status and a second ECG profile during the OFF-period status, determine heart rate dynamics from the first and second ECG profiles, the heart rate dynamics including a plurality of R-R intervals in each ECG profile, generate display data configured to be displayed on a display, and transmit the display data to the display. The display data includes the R-R intervals for each of the first and second ECG profiles. The display data further includes a Poincaré plot.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: October 24, 2023
    Assignee: LIVANOVA US, INC.
    Inventors: Imad Libbus, Scott R. Stubbs, Scott Mazar, Bruce KenKnight, Badri Amurthur
  • Patent number: 11786740
    Abstract: An assessment system is provided for a subject patient implanted with a neurostimulator configured to deliver a stimulation signal having a plurality of ON-periods and OFF-periods. The assessment system includes a wand assembly configured to generate a delivery detection signal indicating delivery of an initiating pulse. The assessment system also includes a processor and a memory associated with the wand. The memory stores instructions that, when executed by the processor, cause the assessment system to record an ECG signal over at least one successive pair of ON- and OFF-periods and determine changes in heart rate dynamics to indicate autonomic response to the stimulation. The wand assembly includes a programming device configured to wirelessly communicate with the neurostimulator and a cable connector configured to form a surface contact with the programming device. The cable connector includes a detection circuit configured to indirectly detect a time of the initiating pulse.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: October 17, 2023
    Assignee: LIVANOVA USA, INC.
    Inventors: Imad Libbus, Scott R. Stubbs, Scott Mazar, Bruce KenKnight, Badri Amurthur
  • Patent number: 11786732
    Abstract: An assessment system is provided for vagus nerve stimulation treatment with a neurostimulator configured to deliver a stimulation signal having a plurality of ON-periods and OFF-periods. The assessment system includes a wand assembly configured to generate a delivery detection signal indicating delivery of the stimulation signal, a lead assembly configured to acquire an ECG signal, and a data acquisition system configured to capture the delivery detection and ECG signals. The assessment system further includes a processor and a non-transitory computer-readable memory storing instructions that, when executed by the processor, cause the assessment system to record the ECG signal over at least one successive pair of ON- and OFF-periods, determine a heart rate dynamic response from the ECG signal, and determine an instantaneous heart rate for each determined R-R interval to determine heart rate dynamics for assessment of autonomic engagement in response to the vagus nerve stimulation treatment.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: October 17, 2023
    Assignee: LivaNova USA, Inc.
    Inventors: Imad Libbus, Scott R. Stubbs, Scott Mazar, Bruce KenKnight, Badri Amurthur
  • Patent number: 11752341
    Abstract: An assessment system is provided for vagus nerve stimulation therapy treatment for congestive heart failure in a subject. The assessment system includes a first interface configured to communicate with a device that delivers a stimulation signal to a vagus nerve of the subject, a second interface configured to capture heart electrical activity of the subject in response to the stimulation signal, and a processor and a non-transitory computer readable memory storing instructions that, when executed by the processor, cause the assessment system to determine and display heart rate dynamics and display a digital ECG signal in real-time in response to the stimulation signal.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: September 12, 2023
    Assignee: LivaNova USA, Inc.
    Inventors: Imad Libbus, Scott R. Stubbs, Scott Mazar, Bruce KenKnight, Badri Amurthur
  • Patent number: 11633600
    Abstract: A neurostimulation system comprises a sensor and a control system. The sensor is configured to detect a cardiac physiological measure of a patient. The control system is programmed to monitor, via the sensor, the cardiac physiological measure during the treatment. The control system is further programmed to detect a change in the cardiac physiological measure during the treatment. The control system is further programmed to determine, based on the detected change in the cardiac physiological measure, a first transition time in a duty cycle of a neurostimulation signal delivered to the patient where the neurostimulation signal transitions between a stimulation OFF period and a stimulation ON period.
    Type: Grant
    Filed: December 29, 2020
    Date of Patent: April 25, 2023
    Assignee: LivaNova USA, Inc.
    Inventors: Imad Libbus, Bruce KenKnight, Scott Stubbs, Scott Mazar
  • Patent number: 11628301
    Abstract: An assessment system is provided for vagus nerve stimulation therapy treatment for congestive heart failure in a subject. The assessment system includes a first interface configured to communicate with a device that delivers a stimulation signal to a vagus nerve of the subject, a second interface configured to capture heart electrical activity of the subject in response to the stimulation signal, and a processor and a non-transitory computer readable memory storing instructions that, when executed by the processor, cause the assessment system to determine and display heart rate dynamics and display a digital ECG signal in real-time in response to the stimulation signal.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: April 18, 2023
    Assignee: LivaNova USA, Inc.
    Inventors: Imad Libbus, Scott R. Stubbs, Scott Mazar, Bruce KenKnight, Badri Amurthur
  • Publication number: 20220203095
    Abstract: A neurostimulation system comprises a sensor and a control system. The sensor is configured to detect a cardiac physiological measure of a patient. The control system is programmed to monitor, via the sensor, the cardiac physiological measure during the treatment. The control system is further programmed to detect a change in the cardiac physiological measure during the treatment. The control system is further programmed to determine, based on the detected change in the cardiac physiological measure, a first transition time in a duty cycle of a neurostimulation signal delivered to the patient where the neurostimulation signal transitions between a stimulation OFF period and a stimulation ON period.
    Type: Application
    Filed: December 29, 2020
    Publication date: June 30, 2022
    Inventors: Imad Libbus, Bruce KenKnight, Scott Stubbs, Scott Mazar
  • Publication number: 20220062641
    Abstract: Systems and methods for customizable titration of an implantable neurostimulator are provided. A method of titrating a neurostimulation signal delivered to a patient from an implantable pulse generator includes delivering a first neurostimulation signal with a first set of parameters, increasing a first value of the first neurostimulation signal at a first rate for a first period of time while delivering the first neurostimulation signal, ceasing delivery of the first neurostimulation signal when the first value reaches a first target value, delivering a second neurostimulation signal with a second set of parameters, and increasing the second neurostimulation signal at a second rate for a second period of time while delivering the second neurostimulation signal.
    Type: Application
    Filed: November 8, 2021
    Publication date: March 3, 2022
    Applicant: LivaNova USA, Inc.
    Inventors: Scott Stubbs, Imad Libbus, Scott Mazar, Bruce KenKnight, Badri Amurthur
  • Patent number: 11167142
    Abstract: Systems and methods for customizable titration of an implantable neurostimulator are provided. A method of titrating a neurostimulation signal delivered to a patient from an implantable pulse generator includes delivering a first neurostimulation signal with a first set of parameters, increasing a first value of the first neurostimulation signal at a first rate for a first period of time while delivering the first neurostimulation signal, ceasing delivery of the first neurostimulation signal when the first value reaches a first target value, delivering a second neurostimulation signal with a second set of parameters, and increasing the second neurostimulation signal at a second rate for a second period of time while delivering the second neurostimulation signal.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: November 9, 2021
    Assignee: LivaNova USA, Inc.
    Inventors: Scott Stubbs, Imad Libbus, Scott Mazar, Bruce KenKnight, Badri Amurthur
  • Publication number: 20210268286
    Abstract: An assessment system is provided for vagus nerve stimulation treatment with a neurostimulator configured to deliver a stimulation signal having a plurality of ON-periods and OFF-periods. The assessment system includes a wand assembly configured to generate a delivery detection signal indicating delivery of the stimulation signal, a lead assembly configured to acquire an ECG signal, and a data acquisition system configured to capture the delivery detection and ECG signals. The assessment system further includes a processor and a non-transitory computer-readable memory storing instructions that, when executed by the processor, cause the assessment system to record the ECG signal over at least one successive pair of ON- and OFF-periods, determine a heart rate dynamic response from the ECG signal, and determine an instantaneous heart rate for each determined R-R interval to determine heart rate dynamics for assessment of autonomic engagement in response to the vagus nerve stimulation treatment.
    Type: Application
    Filed: May 13, 2019
    Publication date: September 2, 2021
    Applicant: LivaNova USA, Inc.
    Inventors: Imad LIBBUS, Scott R. STUBBS, Scott MAZAR, Bruce KENKNIGHT, Badri AMURTHUR
  • Publication number: 20210213290
    Abstract: A system includes a vagus nerve stimulation (VNS) device configured to deliver a vagus nerve stimulation signal having an ON-period status and an OFF-period status, and a processor and a non-transitory computer readable memory. The memory stores instructions that, when executed by the processor, cause the system to synchronously record a first ECG profile of during the ON-period status and a second ECG profile during the OFF-period status, determine heart rate dynamics from the first and second ECG profiles, the heart rate dynamics including a plurality of R-R intervals in each ECG profile, generate display data configured to be displayed on a display, and transmit the display data to the display. The display data includes the R-R intervals for each of the first and second ECG profiles. The display data further includes a Poincaré plot.
    Type: Application
    Filed: May 13, 2019
    Publication date: July 15, 2021
    Applicant: LivaNova USA, Inc.
    Inventors: Imad LIBBUS, Scott R. STUBBS, Scott MAZAR, Bruce KENKNIGHT, Badri AMURTHUR
  • Publication number: 20210213282
    Abstract: An assessment system is provided for a subject patient implanted with a neurostimulator configured to deliver a stimulation signal having a plurality of ON-periods and OFF-periods. The assessment system includes a wand assembly configured to generate a delivery detection signal indicating delivery of an initiating pulse. The assessment system also includes a processor and a memory associated with the wand. The memory stores instructions that, when executed by the processor, cause the assessment system to record an ECG signal over at least one successive pair of ON- and OFF-periods and determine changes in heart rate dynamics to indicate autonomic response to the stimulation. The wand assembly includes a programming device configured to wirelessly communicate with the neurostimulator and a cable connector configured to form a surface contact with the programming device. The cable connector includes a detection circuit configured to indirectly detect a time of the initiating pulse.
    Type: Application
    Filed: May 13, 2019
    Publication date: July 15, 2021
    Applicant: LivaNova USA, Inc.
    Inventors: Imad Libbus, Scott R. Stubbs, Scott Mazar, Bruce KenKnight, Badri Amurthur
  • Publication number: 20210213291
    Abstract: An assessment system is provided for vagus nerve stimulation therapy treatment for congestive heart failure in a subject. The assessment system includes a first interface configured to communicate with a device that delivers a stimulation signal to a vagus nerve of the subject, a second interface configured to capture heart electrical activity of the subject in response to the stimulation signal, and a processor and a non-transitory computer readable memory storing instructions that, when executed by the processor, cause the assessment system to determine and display heart rate dynamics and display a digital ECG signal in real-time in response to the stimulation signal.
    Type: Application
    Filed: May 13, 2019
    Publication date: July 15, 2021
    Applicant: LivaNova USA, Inc.
    Inventors: Imad LIBBUS, Scott R. STUBBS, Scott MAZAR, Bruce KENKNIGHT, Badri AMURTHUR
  • Publication number: 20190076657
    Abstract: Systems and methods for customizable titration of an implantable neurostimulator are provided. A method of titrating a neurostimulation signal delivered to a patient from an implantable pulse generator includes delivering a first neurostimulation signal with a first set of parameters, increasing a first value of the first neurostimulation signal at a first rate for a first period of time while delivering the first neurostimulation signal, ceasing delivery of the first neurostimulation signal when the first value reaches a first target value, delivering a second neurostimulation signal with a second set of parameters, and increasing the second neurostimulation signal at a second rate for a second period of time while delivering the second neurostimulation signal.
    Type: Application
    Filed: September 13, 2018
    Publication date: March 14, 2019
    Inventors: Scott Stubbs, Imad Libbus, Scott Mazar, Bruce KenKnight, Badri Amurthur
  • Patent number: 9150832
    Abstract: A system is provided for stimulating one or more cells, wherein the stimulation is sub-threshold and may alter a transmembrane potential of the one or more cells. For some populations of cells it may be possible to affect the transmembrane potential to gain a therapeutic benefit. Cells of the sino-atrial node spontaneously depolarize predominantly due to the slow depolarization of transmembrane potential. The present system may provide sino-atrial cells with a local field stimulation that while not eliciting an action potential may nonetheless alter local transmembrane potential. Such alteration of transmembrane potential may permit an increase or decrease in a rate of depolarization, and hence modify heart rate.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: October 6, 2015
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Bruce KenKnight, Steven D. Girouard
  • Patent number: 8442631
    Abstract: A method for monitoring a biological cardiac pacemaker. The method may include stimulating a heart at a region selected for implantation of a biological pacemaker and sensing at least one electrical signal indicative of a cardiac depolarization originating in the region selected for implantation of the biological pacemaker. The method may further include sensing at least one subsequent electrical signal produced by the heart and determining if the subsequent electrical signal originated in the region selected for the biological pacemaker or another region of the heart.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: May 14, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Bruce KenKnight, Steven D. Girouard
  • Patent number: 8285378
    Abstract: A system and method for determining patient-specific implantable medical device programming parameters are presented. A set of physiological measures collected through a plurality of sensors monitoring physiological functions in a patient are assimilated. The physiological measures set are analyzed to identify physiological idiosyncrasies specific to the patient and to optimize the therapy to be delivered through an implantable medical device. A patient profile is formed including a plurality of programming parameters and the patient profile is preprogrammed into the implantable medical device prior to implantation in the patient.
    Type: Grant
    Filed: September 27, 2004
    Date of Patent: October 9, 2012
    Assignee: Cardiac Pacemakers, Inc
    Inventors: Bruce KenKnight, Eric Lovett, Adam W. Cates, Amir Tehrani
  • Patent number: 8224443
    Abstract: The present invention includes a method for controlling pacemaker therapy in a patient with an implanted biological pacemaker. The method may include pacing a heart at a predetermined rate using an electronic pacemaker and configuring the pacemaker to periodically enter a biological pacemaker weaning mode. The weaning mode may include ceasing pacing for at least a predetermined length of time and monitoring the heart to detect electrical depolarizations of a ventricle of the heart during the predetermined length of time. The weaning mode may further include determining the length of time between the cessation of pacing and the detected electrical depolarization and determining if the length of time between the cessation of pacing and the detected electrical depolarization is less than a maximum predetermined interval. The pacemaker therapy may be withheld as long as the length of time is less than the maximum predetermined interval.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: July 17, 2012
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Bruce KenKnight, Steven D. Girouard
  • Publication number: 20090069867
    Abstract: An apparatus for providing on-patient communication is described. An implantable medical device including a sensor of physiometry is implanted in a patient. A communication module is remotely interconnected to an interrogation device external to the patient's body and the physiometry is exchanged with the interrogation device. Spoken communication from the patient is received by an implantable microphone including a communication module and is relayed to the interrogation device. voice prompts received from the interrogation device are played by An implantable speaker including a communication module. Pre-defined uniquely identifying patient characteristics are further included with at least one of the implantable medical device, implantable microphone, and implantable speaker and the characteristics are presented on demand by the communication module of the implantable medical device, implantable microphone, and implantable speaker.
    Type: Application
    Filed: September 29, 2008
    Publication date: March 12, 2009
    Inventors: Bruce KenKnight, Gust H. Bardy
  • Publication number: 20090053180
    Abstract: This invention provides pacemaker systems comprising (1) an electronic pacemaker, and (2) a biological pacemaker, wherein the biological pacemaker comprises a cell that functionally expresses a chimeric hyperpolarization-activated, cyclic nucleotide-gated (HCN) ion channel at a level effective to induce pacemaker current in the cell. The invention also provides related biological pacemakers, atrioventricular bridges, methods of making same, and methods of treating a subject afflicted with a cardiac rhythm disorder.
    Type: Application
    Filed: July 21, 2006
    Publication date: February 26, 2009
    Inventors: Michael R. Rosen, Peter R. Brink, Richard B. Robinson, Ira S. Cohen, Steven Girouard, Bruce Kenknight