Patents by Inventor Bruce Kent Gale
Bruce Kent Gale has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230333103Abstract: Detecting a pathogen may include introducing a nonmagnetic metal into the sample where the nonmagnetic metal includes an antibody that is specific to the pathogen to form a complex of the nonmagnetic metal and the pathogen, removing the nonmagnetic metal that is not complexed with the pathogen from the sample, and detecting the presence of the nonmagnetic metal in the sample where the presence of the nonmagnetic metal indicates the presence of the pathogen.Type: ApplicationFiled: June 20, 2023Publication date: October 19, 2023Inventors: Ugochukwu Chinedu Nze, Himanshu Jayant Sant, Bruce Kent Gale, Michael Beeman, Christopher J. Lambert
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Patent number: 10842494Abstract: A nerve repair conduit configured to be secured on first and second portions of a selected nerve. The nerve repair conduit includes a polymeric body having a proximal end, a distal end, an exterior surface and an interior surface defining an interior lumen. In addition, the nerve conduit includes at least one drug reservoir to hold agent(s) that may facilitate nerve regeneration. The drugs diffuse from the drug reservoir(s) into the nerve repair conduit through an outlet (such as a hole or a semipermeable membrane) in proximity to the first and second portions of a selected nerve. The nerve repair conduit may be configured to deliver the agent(s) at a rate having substantially zero-order kinetics and/or at a constant rate over a selected period of time.Type: GrantFiled: August 3, 2018Date of Patent: November 24, 2020Assignee: University of Utah Research FoundationInventors: Jayant P. Agarwal, Bruce Kent Gale, Himanshu Jayant Sant, Pratima Labroo, Jill Shea
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Patent number: 10772633Abstract: A nerve repair conduit configured to be secured on first and second portions of a selected nerve. The nerve repair conduit includes a polymeric body having a proximal end, a distal end, an exterior surface and an interior surface defining an interior lumen. In addition, the nerve conduit includes at least one drug reservoir to hold agent(s) that may, for example, facilitate nerve regeneration. The drugs diffuse from the drug reservoir(s) into the nerve repair conduit through an outlet (e.g., a semipermeable membrane) in proximity to the first and second portions of a selected nerve. The nerve repair conduit may be configured to deliver the agent(s) at a rate having substantially zero-order kinetics and/or at a constant rate over a selected period of time (e.g., at least 1 week).Type: GrantFiled: April 2, 2018Date of Patent: September 15, 2020Assignee: University of Utah Research FoundationInventors: Jayant P. Agarwal, Bruce Kent Gale, Himanshu Jayant Sant, Keng-Min Lin
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Publication number: 20200278349Abstract: Detecting a pathogen may include introducing a nonmagnetic metal into the sample where the nonmagnetic metal includes an antibody that is specific to the pathogen to form a complex of the nonmagnetic metal and the pathogen, removing the nonmagnetic metal that is not complexed with the pathogen from the sample, and detecting the presence of the nonmagnetic metal in the sample where the presence of the nonmagnetic metal indicates the presence of the pathogen.Type: ApplicationFiled: February 28, 2020Publication date: September 3, 2020Inventors: Ugochukwu Chinedu Nze, Himanshu Jayant Sant, Bruce Kent Gale, Michael Beeman, Christopher J. Lambert
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Publication number: 20200271555Abstract: Sample preparation can include obtaining a sample in the form of a liquid mixture and forcing the liquid mixture through a cavitation chamber at an optimal pressure for separating pathogens from particles in the mixture without fragmenting at least 30% of the pathogens. Apparatuses used for sample preparation methods can include a fluid circuit, a cavitation chamber incorporated into the fluid circuit and having a channel with first, second, and third cross-sectional areas, the second cross-sectional area being downstream of and smaller than the first cross-sectional with respect to fluid flow through the fluid circuit and the third cross-sectional area being larger than and downstream of the second cross-sectional area with respect to fluid flow through the fluid circuit. The apparatus can include a pump in fluid communication with the cavitation chamber and a pressure sensor positioned upstream of the cavitation chamber.Type: ApplicationFiled: February 27, 2020Publication date: August 27, 2020Inventors: Ugochukwu Chinedu Nze, Himanshu Jayant Sant, Bruce Kent Gale, Christopher J. Lambert, Dhruv Patel, Michael Beeman
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Patent number: 10300479Abstract: The present disclosure provides apparatuses, systems, and methods involving a spotter apparatus for depositing a substance from a carrier fluid onto a deposition surface in an ordered array. The spotter apparatus includes a loading surface, including a first well and a second well, and a different outlet surface, including a first opening and a second opening, where a first microconduit fluidly couples the first well with the first opening and a second microconduit fluidly couples the second well with the second opening. An overlay is sealed to the outlet surface and penetrated by a deposition channel that is situated to communicate carrier fluid among the first opening, the second opening, and the deposition surface when the overlay is pressed against the deposition surface.Type: GrantFiled: June 8, 2017Date of Patent: May 28, 2019Assignee: Carterra, Inc.Inventors: Bruce Kent Gale, Adam Miles, Joshua Wayne Eckman, Sriram Natarajan, Jim Smith, Mark Eddings
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Publication number: 20190038290Abstract: A nerve repair conduit configured to be secured on first and second portions of a selected nerve. The nerve repair conduit includes a polymeric body having a proximal end, a distal end, an exterior surface and an interior surface defining an interior lumen. In addition, the nerve conduit includes at least one drug reservoir to hold agent(s) that may facilitate nerve regeneration. The drugs diffuse from the drug reservoir(s) into the nerve repair conduit through an outlet (such as a hole or a semipermeable membrane) in proximity to the first and second portions of a selected nerve. The nerve repair conduit may be configured to deliver the agent(s) at a rate having substantially zero-order kinetics and/or at a constant rate over a selected period of time.Type: ApplicationFiled: August 3, 2018Publication date: February 7, 2019Inventors: Jayant P. Agarwal, Bruce Kent Gale, Himanshu Jayant Sant, Pratima Labroo, Jill Shea
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Publication number: 20190029686Abstract: A nerve repair conduit configured to be secured on first and second portions of a selected nerve. The nerve repair conduit includes a polymeric body having a proximal end, a distal end, an exterior surface and an interior surface defining an interior lumen. In addition, the nerve conduit includes at least one drug reservoir to hold agent(s) that may, for example, facilitate nerve regeneration. The drugs diffuse from the drug reservoir(s) into the nerve repair conduit through an outlet (e.g., a semipermeable membrane) in proximity to the first and second portions of a selected nerve. The nerve repair conduit may be configured to deliver the agent(s) at a rate having substantially zero-order kinetics and/or at a constant rate over a selected period of time (e.g., at least 1 week).Type: ApplicationFiled: April 2, 2018Publication date: January 31, 2019Inventors: Jayant P. Agarwal, Bruce Kent Gale, Himanshu Jayant Sant, Keng-Min Lin
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Patent number: 9931121Abstract: A nerve repair conduit configured to be secured on first and second portions of a selected nerve. The nerve repair conduit includes a polymeric body having a proximal end, a distal end, an exterior surface and an interior surface defining an interior lumen. In addition, the nerve conduit includes at least one drug reservoir to hold agent(s) that may, for example, facilitate nerve regeneration. The drugs diffuse from the drug reservoir(s) into the nerve repair conduit through an outlet (e.g., a semipermeable membrane) in proximity to the first and second portions of a selected nerve. The nerve repair conduit may be configured to deliver the agent(s) at a rate having substantially zero-order kinetics and/or at a constant rate over a selected period of time (e.g., at least 1 week).Type: GrantFiled: October 16, 2012Date of Patent: April 3, 2018Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATIONInventors: Jayant P. Agarwal, Bruce Kent Gale, Himanshu Jayant Sant, Keng-Min Lin
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Publication number: 20180001317Abstract: The present disclosure provides apparatuses, systems, and methods involving a spotter apparatus for depositing a substance from a carrier fluid onto a deposition surface in an ordered array, the spotter apparatus comprising a loading surface including a first well and a second well; and a different outlet surface, including a first opening and a second opening, where a first microconduit fluidly couples the first well with the first opening and a second microconduit fluidly couples the second well with the second opening. An overlay is sealed to the outlet surface and penetrated by a deposition channel that is situated to communicate carrier fluid among the first opening, the second opening, and the deposition surface when the overlay is pressed against the deposition surface.Type: ApplicationFiled: June 8, 2017Publication date: January 4, 2018Inventors: Bruce Kent Gale, Adam Miles, Joshua Wayne Eckman, Sriram Natarajan, Jim Smith, Mark Eddings
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Patent number: 8975027Abstract: Disclosed are compositions and a method for amplification and detection of nucleic acid sequences based on continuous flow thermal gradient PCR.Type: GrantFiled: August 8, 2012Date of Patent: March 10, 2015Assignee: University of Utah Research FoundationInventors: Bruce Kent Gale, Niel Davenport Crews, Carl Thomas Wittwer
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Publication number: 20140336681Abstract: A nerve repair conduit configured to be secured on first and second portions of a selected nerve. The nerve repair conduit includes a polymeric body having a proximal end, a distal end, an exterior surface and an interior surface defining an interior lumen. In addition, the nerve conduit includes at least one drug reservoir to hold agent(s) that may, for example, facilitate nerve regeneration. The drugs diffuse from the drug reservoir(s) into the nerve repair conduit through an outlet (e.g., a semipermeable membrane) in proximity to the first and second portions of a selected nerve. The nerve repair conduit may be configured to deliver the agent(s) at a rate having substantially zero-order kinetics and/or at a constant rate over a selected period of time (e.g., at least 1 week).Type: ApplicationFiled: October 16, 2012Publication date: November 13, 2014Inventors: Jayant P. Agarwal, Bruce Kent Gale, Himanshu Jayant Sant, Keng-Min Lin
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Patent number: 8263392Abstract: Disclosed are compositions and a method for amplification and detection of nucleic acid sequences based on continuous flow thermal gradient PCR.Type: GrantFiled: November 14, 2007Date of Patent: September 11, 2012Assignee: University of Utah Research FoundationInventors: Bruce Kent Gale, Niel Davenport Crews, Carl Thomas Wittwer
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Patent number: 8211382Abstract: Specialized microfluidic networks are utilized to deposit substances on sensor surfaces. In particular, a flow-based microfluidic printhead is used as an interface to deliver multiple analytes to a sensor for simultaneous analysis. Furthermore, internal referencing is incorporated into sensor regions for improved sensitivity.Type: GrantFiled: September 22, 2009Date of Patent: July 3, 2012Assignee: Wasatch Microfluidics, LLCInventors: David Myszka, Bruce Kent Gale, Joshua Wayne Eckman, Sriram Natarajan
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Publication number: 20100167288Abstract: Disclosed are compositions and a method for amplification and detection of nucleic acid sequences based on continuous flow thermal gradient PCR.Type: ApplicationFiled: November 14, 2007Publication date: July 1, 2010Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATIONInventors: Bruce Kent Gale, Niel Davenport Crews, Carl Thomas Wittwer
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Publication number: 20100075860Abstract: Specialized microfluidic networks are utilized to deposit substances on sensor surfaces. In particular, a flow-based microfluidic printhead is used as an interface to deliver multiple analytes to a sensor for simultaneous analysis. Furthermore, internal referencing is incorporated into sensor regions for improved sensitivity.Type: ApplicationFiled: September 22, 2009Publication date: March 25, 2010Inventors: David Myszka, Bruce Kent Gale, Joshua Wayne Eckman, Sriram Natarajan