Abstract: Active compounds include compounds of Formula I and Formula II are described: along with compositions containing the same and methods of use thereof.

Abstract: The present invention provides compounds of Formula I: wherein: R1 is a label (e.g., a detectable group and an anti-tumor agent); L is present or absent and when present is a linking group; and x represents an integer from 1 to 10; or a pharmaceutically acceptable salt thereof. The compounds are useful for, among other things, identifying cysteine sulfenic acids in proteins and monitoring oxidative damage in proteins and cells. Adduct formation can be detected using analytical methods such as electrospray ionization mass spectrometry and fluorescence.

Abstract: The various embodiments of the present invention provide a system, including methods, apparatus and kits for connecting bones and/or bone portions using a multi-part bone connector with one or more rotating joints.

Abstract: Impact-modified polystyrene resins such as HIPS and ABS resins are blended with a brominated vinyl aromatic-butadiene copolymer. The brominated copolymer is an effective flame retardant in these compositions, allowing in many cases a V-1 rating to be achieved in the UL-94 vertical burn test.

Abstract: Embodiments of the invention are directed to a distal interphalangeal (“DIP”) fusion device for connecting a first bone of a patient to a second, adjacent bone of the patient. The device may include an anchor assembly and a compressor assembly. In another embodiment, a separate compressor base assembly is included. In yet another embodiment an access port assembly is included. The anchor assembly is rotationally coupled to one end of the compressor assembly, such that the compressor assembly may rotate about the anchor assembly within a semi-spherical zone (three degrees of rotational freedom) and translate axially (one degree of translational freedom). In an operative position, the anchor assembly is anchored in an intermediate phalanx of a digit of a patient, the compressor assembly is contained in a distal phalanx of the digit, and the distal phalanx is flexed relative to the intermediate phalanx to create a joint angle.

Abstract: The present invention provides a system, including methods, apparatus and kits for stabilizing and compressing bone fractures using a compression plate apparatus for stabilizing bone fragments with compression comprising a plate having at least two bone screw holes adapted to accept at least one bone screw each, the plate additionally having at least one elongate hole through the plate; a rack comprising rack teeth located along at least one linear edge of the elongate hole; a pinion axle assembly comprising a pinion axle having a head portion, a pinion gear having complementary gear teeth for engaging the rack teeth and a lower portion having threads for engaging bone.

Abstract: A system, including methods, apparatus and kits for connecting bones and/or bone portions using a multi-part bone connector with one or more rotating joints is disclosed. A flexible bone fusion apparatus is provided having an anchor and a compressor, each of which engages with a coupler to provide axial and/or linear rotation of the apparatus. Alternatively, a compressor and an anchor may directly join with each other at a shared interface. Tools for installing and compressing the apparatus are provided. Also provided is a method for fusing two bones or bone portions to create a non-linear post-fusion orientation. A further aspect of the disclosure is a method for maintaining thread synchronization of a bone fusion apparatus having a discontinuous thread.

Abstract: The present invention provides compounds of Formula I: wherein: R1 is a label (e.g., a detectable groups; an anti-tumor agent)s; L is present or absent and when present is a linking group; and x represents an integer from 1 to 10; or a pharmaceutically acceptable salt thereof. the compounds are useful for, among other things, identifying cysteine sulfenic acids in proteins and monitoring oxidative damage in proteins and cells.

Abstract: Brominated and epoxidized organic compounds are useful flame retardants for polymers such as polystyrene. The organic compounds contain both bromine and oxirane groups, and have molecular weights of at least 1500. The brominated and epoxidized organic compounds can be prepared by sequentially brominating and epoxiding (in either order) a starting compound that contains multiple non-conjugated carbon-carbon double bonds.

Abstract: Active compounds of Formula I are described: wherein: R1 and R2 are each independently C1-C4 alkyl; or R1 and R2 together form a C2-C7 alkylene chain; and Z is a non-steroidal anti-inflammatory drug (NSAID); along with pharmaceutically acceptable salts and prodrug thereof, and methods of using the same.

Abstract: A system, including methods, apparatus and kits for connecting bones and/or bone portions using a multi-part bone connector with one or more rotating joints is disclosed. A flexible bone fusion apparatus is provided having an anchor and a compressor, each of which engages with a coupler to provide axial and/or linear rotation of the apparatus. Alternatively, a compressor and an anchor may directly join with each other at a shared interface. Tools for installing and compressing the apparatus are provided. Also provided is a method for fusing two bones or bone portions to create a non-linear post-fusion orientation. A further aspect of the disclosure is a method for maintaining thread synchronization of a bone fusion apparatus having a discontinuous thread.

Abstract: The present invention provides a method of synthesizing compounds of Formula I: wherein: R1 is a label (e.g., a detectable groups; an anti-tumor agents); L is present or absent and when present is a linking group; and x represents an integer from 1 to 10; or a pharmaceutically acceptable salt thereof. the compounds are useful for, among other things, identifying cysteine sulfenic acids in proteins and monitoring oxidative damage in proteins and cells.

Abstract: A method of treating cancer in a subject in need thereof comprises administering said subject reserpine, yohimbine, an analog thereof, or a pharmaceutically acceptable salt or prodrug thereof, in an amount effective to treat the cancer. Compounds and compositions useful for carrying out the method are also described.

Abstract: Brominated styrene-butadiene copolymers are recovered from solutions in a halogenated solvent by an anti-solvent precipitation process. The precipitation process is performed by adding the anti-solvent to the brominated styrene-butadiene copolymer solution. By performing the precipitation using this specific order of addition, a denser product is obtained that is easier to dry. The recovered product shows a reduced tendency to act as a nucleating agent when it is used as a flame retardant additive in an extrusion foaming process.

Abstract: Butadiene polymers are brominated using a quaternary ammonium or quaternary phosphonium tribromide as the brominating agent. The bromination is performed in a solvent mixture than contains at least one polyhalogenated alkane and at least one monohalogenated alkane. The process proceeds easily under mild conditions and allows high conversions to be achieved easily.

Abstract: Butadiene polymers are brominated using tetraethylammonium tribromide as the brominating agent. The bromination is performed in a solvent for the starting polymer and for the tetraethylammonium bromide that is formed as a reaction byproduct. The process proceeds easily under mild conditions. In some cases, a solution of the brominated polymer and the tetraethylammonium monobromide is produced; this solution separates into a layer that contains the brominated polymer and another layer that contains most or all of the tetraethylammonium monobromide salt. In other cases, the brominated polymer precipitates from the reaction mixture and is separated from the tetraethylammonium monobromide salt in that manner. This process therefore permits the tetraethylammonium monobromide reaction by-product to be separated easily from the brominated product, and allows aqueous washing steps to be reduced or eliminated.

Abstract: Active compounds of Formula I are described: wherein: R1 and R2 are each independently C1-C4 alkyl; or R1 and R2 together form a C2-C7 alkylene chain; and Z is a non-steroidal anti-inflammatory drug (NSAID); along with pharmaceutically acceptable salts and prodrug thereof, and methods of using the same.

Abstract: Disclosed are nitroxide modified NSAID compounds of the formula (I) or a pharmaceutically acceptable salt or enantiomer thereof: in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and n are defined herein and pharmaceutical compositions thereof. Further disclosed is a method of treating or preventing various disorders, such as inflammation, cancer, diabetes, a cardiovascular disorder, weight gain, polyps, and/or chronic pain, in a patient comprising administering an effective amount of a compound or pharmaceutically acceptable salt or enantiomer of formula (I). A method of imaging the compound or pharmaceutically acceptable salt or enantiomer of formula (I) in the body of the animal is also provided.

Abstract: Active compounds of Formula I are described: wherein: R1 and R2 are each independently C1-C4 alkyl; or R1 and R2 together form a C2-C7 alkylene chain; and Z is a non-steroidal anti-inflammatory drug (NSAID); along with pharmaceutically acceptable salts and prodrug thereof, and methods of using the same.

Abstract: Certain brominated polymers compounds are effective FR additives for combustible organic polymers. These FR additives include: i) a copolymer having styrene and 2,3-dibromopropylmaleimide repeating units; ii) a brominated polyester having aliphatically bound bromine; iii) an allyl ether of a ring-brominated novolac resin; iv) a 3-bromo-2-hydroxypropyl ether of a novolac resin; v) a 2,3-dibromopropyl ether of a cresol novolac resin; and vi) a brominated ROMP polymer or copolymer.