Patents by Inventor Bruce Klitzman
Bruce Klitzman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230372694Abstract: The present disclosure describes intravascular oxygenation systems and methods with one or more of improved oxygen diffusion flux, improved resistance to bubble formation on the surface of non-porous hollow fibers, and reduced size. The systems and methods include a pneumatic inlet coupled to a pneumatic source that provides a gas containing oxygen at a high pressure. A plurality of hollow fiber membranes (HFM) are in pneumatic communication with the pneumatic inlet to receive the gas containing oxygen and with an outlet to exhaust a partially deoxygenated gas. An electronic controller drives the motor to oscillate the plurality of HFMs to cause a diffusive flux of the gas containing oxygen from the plurality of HFMs into a region of interest of a subject. The electronic controller may drive the motor according to an oscillation pattern, which may include a macro-oscillation with superimposed micro-oscillations.Type: ApplicationFiled: July 26, 2023Publication date: November 23, 2023Inventors: Tobias Straube, Stewart Farling, Bruce Klitzman, Marc Deshusses, Travis Vesel, Ira Cheifetz
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Patent number: 11771883Abstract: The present disclosure describes intravascular oxygenation systems and methods with one or more of improved oxygen diffusion flux, improved resistance to bubble formation on the surface of non-porous hollow fibers, and reduced size. The systems and methods include a pneumatic inlet coupled to a pneumatic source that provides a gas containing oxygen at a high pressure. A plurality of hollow fiber membranes (HFM) are in pneumatic communication with the pneumatic inlet to receive the gas containing oxygen and with an outlet to exhaust a partially deoxygenated gas. An electronic controller drives the motor to oscillate the plurality of HFMs to cause a diffusive flux of the gas containing oxygen from the plurality of HFMs into a region of interest of a subject. The electronic controller may drive the motor according to an oscillation pattern, which may include a macro-oscillation with superimposed micro-oscillations.Type: GrantFiled: October 10, 2022Date of Patent: October 3, 2023Assignee: Duke UniversityInventors: Tobias Straube, Stewart Farling, Bruce Klitzman, Marc Deshusses, Travis Vesel, Ira Cheifetz
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Patent number: 11723804Abstract: An apparatus is provided for draining aqueous humor from an eye for reducing intraocular pressure. The draining apparatus comprises a tube defining a passage for fluid flow between an inlet end and an outlet end. An outlet assembly contacts the conjunctival layer externally of the eyeball. The outlet assembly comprises a housing in fluid communication with the outlet end of the tube and having an aperture for allowing egress of aqueous humor onto the external ocular surface. A resistive component is disposed in the housing for providing resistance to a flow of aqueous humor. A pair of tabs project outwardly and are adapted to be disposed subconjunctivally for securing the draining apparatus relative to the eyeball.Type: GrantFiled: August 5, 2019Date of Patent: August 15, 2023Assignee: Alievio, Inc.Inventors: Lucinda J. Camras, Rand Allingham, Bruce Klitzman, Sanjay Asrani
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Publication number: 20230233738Abstract: Described herein are compositions and method for autologous adipose tissue grafting. In one embodiment, the composition comprises a recombinant partially ordered polypeptide (Fractomer) or “Fractomer” and adipose tissue from a subject. In one aspect, the Fractomer has the general structure of [(GXGVP)n-?-helix]m, where X can be any amino acid except proline and ?-helix is any polyalanine based ?-helix having about 5 to 50 Alanine residues. In another aspect, the Fractomer has the structure [(GXGVP)n-GX1(A)25X1]m; where X is A or V; X1 is K or D; n is an integer from 10 to 20; and m is an integer from 4 to 8.Type: ApplicationFiled: June 4, 2021Publication date: July 27, 2023Inventors: Stefan Roberts, Ashutosh Cilkoti, Bruce Klitzman, Scott Hollenbeck
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Publication number: 20230110567Abstract: The present disclosure describes intravascular oxygenation systems and methods with one or more of improved oxygen diffusion flux, improved resistance to bubble formation on the surface of non-porous hollow fibers, and reduced size. The systems and methods include a pneumatic inlet coupled to a pneumatic source that provides a gas containing oxygen at a high pressure. A plurality of hollow fiber membranes (HFM) are in pneumatic communication with the pneumatic inlet to receive the gas containing oxygen and with an outlet to exhaust a partially deoxygenated gas. An electronic controller drives the motor to oscillate the plurality of HFMs to cause a diffusive flux of the gas containing oxygen from the plurality of HFMs into a region of interest of a subject. The electronic controller may drive the motor according to an oscillation pattern, which may include a macro-oscillation with superimposed micro-oscillations.Type: ApplicationFiled: October 10, 2022Publication date: April 13, 2023Inventors: Tobias Straube, Stewart Farling, Bruce Klitzman, Marc Deshusses, Travis Vesel, Ira Cheifetz
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Publication number: 20200061214Abstract: The present disclosure provides compositions and methods for real-time oxygen measurements. More particularly, the present disclosure relates to oxygen-sensing compositions including a metalloporphyrin compound.Type: ApplicationFiled: February 23, 2018Publication date: February 27, 2020Inventors: Mohamed Ibrahim, John Wu, Ryan Schweller, Bruce Klitzman
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Publication number: 20190358086Abstract: An apparatus is provided for draining aqueous humor from an eye for reducing intraocular pressure. The draining apparatus comprises a tube defining a passage for fluid flow between an inlet end and an outlet end. An outlet assembly contacts the conjunctival layer externally of the eyeball. The outlet assembly comprises a housing in fluid communication with the outlet end of the tube and having an aperture for allowing egress of aqueous humor onto the external ocular surface. A resistive component is disposed in the housing for providing resistance to a flow of aqueous humor. A pair of tabs project outwardly and are adapted to be disposed subconjunctivally for securing the draining apparatus relative to the eyeball.Type: ApplicationFiled: August 5, 2019Publication date: November 28, 2019Inventors: Lucinda J. Camras, Rand Allingham, Bruce Klitzman, Sanjay Asrani
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Publication number: 20190314567Abstract: Intravascular membrane oxygenator catheter systems and methods are disclosed, along with methods of making and using the same. A catheter system includes a catheter shaft having a wall that extends from a proximal end to a distal end along a longitudinal axis to define a lumen, a plurality of hollow fiber membrane loops each having a proximal portion positioned within the lumen of the catheter shaft and a distal portion extending beyond the lumen of the catheter shaft, the hollow fiber membrane loops are nonporous with solid walls; a pneumatic source in pneumatic communication with the hollow fiber membrane loops. The pneumatic source provides a gas containing oxygen at a pressure sufficient to cause a diffusive flux of the gas containing oxygen from an interior of the hollow fiber membrane loops to a fluid exterior to the hollow fiber membrane loops in a region of interest of a subject.Type: ApplicationFiled: April 11, 2018Publication date: October 17, 2019Inventors: Tobias Straube, Ken Gall, Bruce Klitzman, Ira Cheifetz, Roy Glenn Morris, Travis Vesel, Jennifer Chien
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Patent number: 10369050Abstract: An apparatus is provided for draining aqueous humor from an eye for reducing intraocular pressure. The draining apparatus comprises a tube defining a passage for fluid flow between an inlet end and an outlet end. An outlet assembly contacts the conjunctival layer externally of the eyeball. The outlet assembly comprises a housing in fluid communication with the outlet end of the tube and having an aperture for allowing egress of aqueous humor onto the external ocular surface. A resistive component is disposed in the housing for providing resistance to a flow of aqueous humor. A pair of tabs project outwardly and are adapted to be disposed subconjunctivally for securing the draining apparatus relative to the eyeball.Type: GrantFiled: July 23, 2018Date of Patent: August 6, 2019Assignee: Camras Vision Inc.Inventors: Lucinda J. Camras, Rand Allingham, Bruce Klitzman, Sanjay Asrani
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Patent number: 10201451Abstract: An apparatus is provided for draining aqueous humor from an eye for reducing intraocular pressure. The draining apparatus comprises a tube defining a passage for fluid flow between an inlet end and an outlet end. An outlet assembly contacts the conjunctival layer externally of the eyeball. The outlet assembly comprises a housing in fluid communication with the outlet end of the tube and having an aperture for allowing egress of aqueous humor onto the external ocular surface. A resistive component is disposed in the housing for providing resistance to a flow of aqueous humor. A pair of tabs project outwardly and are adapted to be disposed subconjunctivally for securing the draining apparatus relative to the eyeball.Type: GrantFiled: August 29, 2014Date of Patent: February 12, 2019Assignee: Camras Vision Inc.Inventors: Lucinda J. Camras, Rand Allingham, Bruce Klitzman, Sanjay Asrani
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Publication number: 20180325733Abstract: An apparatus is provided for draining aqueous humor from an eye for reducing intraocular pressure. The draining apparatus comprises a tube defining a passage for fluid flow between an inlet end and an outlet end. An outlet assembly contacts the conjunctival layer externally of the eyeball. The outlet assembly comprises a housing in fluid communication with the outlet end of the tube and having an aperture for allowing egress of aqueous humor onto the external ocular surface. A resistive component is disposed in the housing for providing resistance to a flow of aqueous humor. A pair of tabs project outwardly and are adapted to be disposed subconjunctivally for securing the draining apparatus relative to the eyeball.Type: ApplicationFiled: July 23, 2018Publication date: November 15, 2018Inventors: Lucinda J. Camras, Rand Allingham, Bruce Klitzman, Sanjay Asrani
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Publication number: 20160058615Abstract: An apparatus is provided for draining aqueous humor from an eye for reducing intraocular pressure. The draining apparatus comprises a tube defining a passage for fluid flow between an inlet end and an outlet end. An outlet assembly contacts the conjunctival layer externally of the eyeball. The outlet assembly comprises a housing in fluid communication with the outlet end of the tube and having an aperture for allowing egress of aqueous humor onto the external ocular surface. A resistive component is disposed in the housing for providing resistance to a flow of aqueous humor. A pair of tabs project outwardly and are adapted to be disposed subconjunctivally for securing the draining apparatus relative to the eyeball.Type: ApplicationFiled: August 29, 2014Publication date: March 3, 2016Inventors: LUCINDA J. CAMRAS, RAND ALLINGHAM, BRUCE KLITZMAN, SANJAY ASRANI
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Publication number: 20090217840Abstract: The invention provides tissue marking pigment or dye particle retained within a tissue cell, the cellular cytoplasm, or one or more intracellular organelles. Also, the invention provides nanoparticles, which are phagocytosed, engulfed or otherwise entrapped by cells.Type: ApplicationFiled: August 2, 2006Publication date: September 3, 2009Applicant: FREEDOM-2, INC.Inventors: Ljiljana Kundakovic, Bruce Klitzman, Kim Edward Koger, Edith Mathiowitz, Craig A. Drill
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Publication number: 20080028990Abstract: The invention provides a modified tissue marking pigment and a method for preparing a modified tissue marking pigment by altering protein adsorption to the surface of the pigment particle, activation of key receptors on important immune cells or altering the pigment particle morphology.Type: ApplicationFiled: July 14, 2005Publication date: February 7, 2008Applicant: FREEDOM-2, LLCInventor: Bruce Klitzman
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Patent number: 6013122Abstract: Tattoo inks are composed of pigments or dyes combined with a tattoo pigment vehicle which entraps, encases, incorporates, complexes, encapsulates, or is otherwise associated with the pigment to form pigment/vehicle complexes that retain the pigment in the tissue. The vehicle can be chosen so that pigments which alone are unsuitable for tattooing can be used for tattooing and optionally can be retained in the tissue permanently. Alternatively, the vehicle renders the tattoo erasable, wherein the tattoo disappears after imposition of an exogenous energy. Alternatively, the tattoo pigment vehicle renders the tattoo semi-permanent, so that the tattoo spontaneously disappears at a predetermined time.Type: GrantFiled: August 18, 1998Date of Patent: January 11, 2000Assignee: Option Technologies, Inc.Inventors: Bruce Klitzman, Kim Edward Koger