Patents by Inventor Bruce Kuczynski

Bruce Kuczynski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Manufacturing process to control particle size
    Patent number: 6730286
    Abstract: A process for preparing a sterile injectable suspension of radiolabeled macroaggregated serum albumin suitable for use in scanning a mammalian patient consisting of: 1) purifying serum albumin with a saline solution; 2) buffering the purified serum albumin; 3) adding stannous halide in HCl solution to the buffered mixture to obtain a reaction mixture; 4) gradually heating and cooling the reaction mixture to form macroaggregate particles; 5) separating the macroaggregates from the reaction mixture; 6) suspending the macroaggregates in sterile water for injection; 7) adding purified serum albumin; 8) lyophilizing the suspension; and 9) reconstituting the radiolabeled lyophilizate with 99mTc. The invention also includes a process for preparing a stable, sterile lyophilizate of macroaggregate particles of human serum albumin consisting of steps 1-7.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: May 4, 2004
    Assignee: Bracco Diagnostics, Inc.
    Inventors: Ernst Schramm, Rama K. Narra, Bruce Kuczynski, Julius P. Zodda
  • Manufacturing process to control particle size
    Publication number: 20020182148
    Abstract: A process for preparing a sterile injectable suspension of radiolabeled macroaggregated serum albumin suitable for use in scanning a mammalian patient consisting of:
    Type: Application
    Filed: February 28, 2001
    Publication date: December 5, 2002
    Inventors: Ernst Schramm, Rama K. Narra, Bruce Kuczynski, Julius P. Zodda