Patents by Inventor Bruce L. Innis

Bruce L. Innis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multivalent dengue virus vaccine
    Patent number: 7217418
    Abstract: The present invention provides vaccine compositions of attenuated dengue virus. More specifically, the attenuated virus is produced by serial passage in PDK cells. The invention also provides methods for stimulating the immune system of an individual to induce protection against all four dengue virus serotypes by administration of attenuated dengue-1, dengue-2, dengue-3, and dengue-4 virus.
    Type: Grant
    Filed: July 24, 2003
    Date of Patent: May 15, 2007
    Assignee: United States of America as represented by the Secretary of the Army
    Inventors: Kenneth H. Eckels, Joseph B. Putnak, Doria R. Dubois, Bruce L. Innis, Charles H. Hoke, Wellington Sun, Niranjan Kanesa-Thasan
  • Multivalent dengue virus vaccine
    Patent number: 6638514
    Abstract: The present invention provides vaccine compositions of attenuated dengue virus. More specifically, the attenuated virus is produced by serial passage in PDK cells. The invention also provides methods for stimulating the immune system of an individual to induce protection against all four dengue virus serotypes by administration of attenuated dengue-1, dengue-2, dengue-3, and dengue-4 virus.
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: October 28, 2003
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Kenneth H. Eckels, Joseph R. Putnak, Doria R. Dubois, Bruce L. Innis, Charles H. Hoke, Sun Wellington, Niranjan Kanessa-thasan
  • Adaptation of virus to vertebrate cells
    Patent number: 6613556
    Abstract: The present invention provides a method for replicating virus to high titer in cultured mammalian cells by infecting the mammalian cells with the high titer virus strain to obtain infected cells, specifically, attenuated dengue virus strains of serotype 1, 2, 3, and 4. The resulting replicated virus is suitable for use in vaccines and vaccination methods which are also provided by the invention.
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: September 2, 2003
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Kenneth H. Eckels, Joseph R. Putnak, Bruce L. Innis
  • Attenuated dengue-4 virus vaccine
    Patent number: 6537557
    Abstract: The present invention provides vaccine compositions of attenuated dengue-4 virus. More specifically, the attenuated virus is produced by serial passage in PDK cells. The invention also provides methods for stimulating the immune system of an individual to induce protection against dengue-4 virus by administration of attenuated dengue-4 virus.
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: March 25, 2003
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Kenneth H. Eckels, Joseph R. Putnak, Doria R. Dubois, Bruce L. Innis, Charles H. Hoke, David Vaughn
  • Attenuated dengue-3 virus vaccine
    Patent number: 6528065
    Abstract: The present invention provides immunogenic compositions of attenuated dengue-1 virus. More specifically, the attenuated virus is produced by serial passage in PDK cells. The invention also provides methods for stimulating the immune system of an individual to induce protection against dengue-1 virus by administration of attenuated dengue-1 virus.
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: March 4, 2003
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Kenneth H. Eckels, Joseph R. Putnak, Doria R. Dubois, Bruce L. Innis, Charles H. Hoke, David Vaughn
  • Attenuated dengue-2 virus vaccine
    Patent number: 6511667
    Abstract: The present invention provides vaccine compositions of attenuated dengue-2 virus. More specifically, the attenuated virus is produced by serial passage in PDK cells. The invention also provides methods for stimulating the immune system of an individual to induce protection against dengue-2 virus by administration of attenuated dengue-2 virus.
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: January 28, 2003
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Kenneth H. Eckels, Joseph R. Putnak, Doria R. Dubois, Bruce L. Innis, Charles H. Hoke, David Vaughn, Erik A. Henchai, Niranian Kanesa-thasan