Abstract: An apparatus and method for the self-administration of a plurality of doses of an intranasal liquid pharmaceutical composition, including opioid analgesics, that includes a drug delivery device containing a plurality of sealed vials, each vial containing a predetermined volume of the pharmaceutical composition, a pump assembly for conveying the liquid pharmaceutical composition from the interior of the vial and discharging it as a nasal spray in response to manual activation by the patient, and programmable means for sequentially advancing a vial to the ready position after passage of a prescribed time interval following the last activation of the delivery device.

Abstract: A method of regulating a target system generates a plurality of digital signals which define a reference pulse train with a frequency dependent upon a reference signal. A target system to be regulated (such as a transport speed of a paper transport assembly in a printer) has an output in the form of a plurality of digital signals defining a feedback pulse train having a frequency. The frequency of the reference pulse train is compared with the frequency of the feedback pulse train. A control signal is generated dependent upon the frequency comparison, and is provided as an input to the target system.

Abstract: An apparatus and method for the self-administration of a plurality of doses of an intranasal liquid pharmaceutical composition, including opioid analgesics, that includes a drug delivery device containing a plurality of sealed vials, each vial containing a predetermined volume of the pharmaceutical composition, a pump assembly for conveying the liquid pharmaceutical composition from the interior of the vial and discharging it as a nasal spray in response to manual activation by the patient, and programmable means for sequentially advancing a vial to the ready position after passage of a prescribed time interval following the last activation of the delivery device.

Abstract: A control system in the form of an all-digital phase-locked loop controls movement of a DC motor. The control system includes a movement detector in the form of an optical encoder to detect movement of a DC motor. A digital phase detector compares output of a feedback signal from the movement detector and a reference signal. The digital phase detector is phase frequency detector that follows a describing function to model non-linear components of the reference signal. A digital loop filter then filters noise from the comparison signal and the filtered signal is amplified to control the DC motor. The phase frequency detector includes a state machine to track a time varying reference signal and selectively output a response to provide for system damping.

Abstract: An apparatus and method for the self-administration of a plurality of doses of an intranasal liquid pharmaceutical composition, including opioid analgesics, that includes a drug delivery device containing a plurality of sealed vials, each vial containing a predetermined volume of the pharmaceutical composition, a pump assembly for conveying the liquid pharmaceutical composition from the interior of the vial and discharging it as a nasal spray in response to manual activation by the patient, and programmable means for sequentially advancing a vial to the ready position after passage of a prescribed time interval following the last activation of the delivery device.