Patents by Inventor Bruce Lessey
Bruce Lessey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10234465Abstract: Methods for identifying subjects as candidates for embryo implantation are provided. In some embodiments, the methods include providing a sample of endometrium isolated from a subject during the second half of the subject's menstrual cycle and determining whether the subject is a candidate based on the expression of BCL6 in the sample. Also provided are methods for identifying an increased risk for implantation failure subsequent to in vitro fertilization (IVF) and/or frozen embryo transfer (FET), methods for detecting endometrial receptivity, methods for facilitating diagnoses of infertility, methods for increasing the likelihood of embryo implantation, methods for detecting the presence of endometriosis, and methods for managing treatment of subjects with potential endometriosis, subfertility, or both.Type: GrantFiled: March 19, 2015Date of Patent: March 19, 2019Assignees: The University of North Carolina at Chapel Hill, Greenville Health SystemsInventors: Steven Young, Bruce Lessey
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Patent number: 10167512Abstract: Methods for diagnosis and treatment of endometriosis are described. Methods utilize the recognition that leukocyte miRNAs can be dramatically dysregulated subjects suffering from endometriosis. Accordingly, leukocyte miRNAs, as well as polynucleotides encoding the miRNAs, can be utilized in the diagnosis and treatment of endometriosis.Type: GrantFiled: May 11, 2017Date of Patent: January 1, 2019Assignee: University of South CarolinaInventors: Mitzi Nagarkatti, Juhua Zhou, Bruce A. Lessey, Prakash Nagarkatti
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Publication number: 20170247763Abstract: Methods for diagnosis and treatment of endornetriosis are described. Methods utilize the recognition that leukocyte miRNAs can be dramatically dysregulated subjects suffering from endometriosis. Accordingly, leukocyte miRNAs, as well as polynucleotides encoding the miRNAs, can be utilized in the diagnosis and treatment of endometriosis.Type: ApplicationFiled: May 11, 2017Publication date: August 31, 2017Inventors: Mitzi Nagarkatti, Juhua Zhou, Bruce A. Lessey, Prakash Nagarkatti
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Patent number: 9650676Abstract: Methods for diagnosis and treatment of endometriosis are described. Methods utilize the recognition that leukocyte miRNAs can be dramatically dysregulated subjects suffering from endometriosis. Accordingly, leukocyte miRNAs, as well as polynucleotides encoding the miRNAs, can be utilized in the diagnosis and treatment of endometriosis.Type: GrantFiled: March 19, 2015Date of Patent: May 16, 2017Assignee: University of South CarolinaInventors: Mitzi Nagarkatti, Juhua Zhou, Bruce A. Lessey, Prakash Nagarkatti
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Publication number: 20170089923Abstract: Methods for identifying subjects as candidates for embryo implantation are provided. In some embodiments, the methods include providing a sample of endometrium isolated from a subject during the second half of the subject's menstrual cycle and determining whether the subject is a candidate based on the expression of BCL6 in the sample. Also provided are methods for identifying an increased risk for implantation failure subsequent to in vitro fertilization (IVF) and/or frozen embryo transfer (FET), methods for detecting endometrial receptivity, methods for facilitating diagnoses of infertility, methods for increasing the likelihood of embryo implantation, methods for detecting the presence of endometriosis, and methods for managing treatment of subjects with potential endometriosis, subfertility, or both.Type: ApplicationFiled: March 19, 2015Publication date: March 30, 2017Applicants: The University of North Carolina at Chapel Hill, Greenville Health SystemInventors: Steven Young, Bruce Lessey
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Publication number: 20150267257Abstract: Methods for diagnosis and treatment of endometriosis are described. Methods utilize the recognition that leukocyte miRNAs can be dramatically dysregulated subjects suffering from endometriosis. Accordingly, leukocyte miRNAs, as well as polynucleotides encoding the miRNAs can be utilized in the diagnosis and treatment of endometriosis.Type: ApplicationFiled: March 19, 2015Publication date: September 24, 2015Inventors: Mitzi Nagarkatti, Juhua Zhou, Bruce A. Lessey, Prakash Nagarkatti
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Patent number: 6979533Abstract: Methods for detecting receptivity of mammalian endometrium to embryo implantation comprising obtaining a sample of the endometrium, contacting the endometrium with a monoclonal antibody for ?3 and detecting ?3 in the endometrium. The invention also provides for methods of diagnosing infertility in a mammal and methods of detecting the window of embryo implantation in endometrium. Methods of in vitro fertilization, methods of preventing embryo implantation and a method of monitoring endometrial maturation are also within the scope of the present invention. The present invention is also directed to contraceptives. Diagnostic kits useful in the practice of the methods of the invention are also provided.Type: GrantFiled: June 16, 2003Date of Patent: December 27, 2005Assignee: The Trustees of the University of PennsylvaniaInventor: Bruce Lessey
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Patent number: 6960445Abstract: Methods of diagnosing infertility in a mammal that include detecting the presence and level of a ?3 integrin subunit in an endometrium sample of a mammal at a plurality of stages of the endometrial cycle and correlating delayed appearance or a reduced level of ?3 integrin subunit expression with infertility are provided. Diagnostic kits useful in the practice of the methods of the invention are also provided.Type: GrantFiled: January 21, 2004Date of Patent: November 1, 2005Assignee: The Trustees of the University of PennsylvaniaInventor: Bruce Lessey
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Publication number: 20040152141Abstract: Methods of diagnosing infertility in a mammal that include detecting the presence and level of a &bgr;3 integrin subunit in an endometrium sample of a mammal at a plurality of stages of the endometrial cycle and correlating delayed appearance or a reduced level of &bgr;3 integrin subunit expression with infertility are provided. Diagnostic kits useful in the practice of the methods of the invention are also provided.Type: ApplicationFiled: January 21, 2004Publication date: August 5, 2004Inventor: Bruce Lessey
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Patent number: 6733979Abstract: Methods for detecting receptivity of mammalian endometrium to embryo implantation comprising obtaining a sample of the endometrium, contacting the endometrium with a monoclonal antibody for &bgr;3 and detecting &bgr;3 in the endometrium. The invention also provides for methods of diagnosing infertility in a mammal and methods of detecting the window of embryo implantation in endometrium. Methods of in vitro fertilization, methods of preventing embryo implantation and a method of monitoring endometrial maturation are also within the scope of the present invention. The present invention is also directed to contraceptives. Diagnostic kits useful in the practice of the methods of the invention are also provided.Type: GrantFiled: September 8, 1998Date of Patent: May 11, 2004Assignee: The Trustees of the University of PennsylvaniaInventor: Bruce Lessey
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Publication number: 20030228636Abstract: Methods for detecting receptivity of mammalian endometrium to embryo implantation comprising obtaining a sample of the endometrium, contacting the endometrium with a monoclonal antibody for &bgr;3 and detecting &bgr;3 in the endometrium. The invention also provides for methods of diagnosing infertility in a mammal and methods of detecting the window of embryo implantation in endometrium. Methods of in vitro fertilization, methods of preventing embryo implantation and a method of monitoring endometrial maturation are also within the scope of the present invention. The present invention is also directed to contraceptives. Diagnostic kits useful in the practice of the methods of the invention are also provided.Type: ApplicationFiled: June 16, 2003Publication date: December 11, 2003Inventor: Bruce Lessey
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Publication number: 20030113806Abstract: Methods for detecting receptivity of mammalian endometrium to embryo implantation comprising obtaining a sample of the endometrium, contacting the endometrium with a monoclonal antibody for &bgr;3 and detecting &bgr;3 in the endometrium. The invention also provides for methods of diagnosing infertility in a mammal and methods of detecting the window of embryo implantation in endometrium. Methods of in vitro fertilization, methods of preventing embryo implantation and a method of monitoring endometrial maturation are also within the scope of the present invention. The present invention is also directed to contraceptives. Diagnostic kits useful in the practice of the methods of the invention are also provided.Type: ApplicationFiled: September 8, 1998Publication date: June 19, 2003Inventor: BRUCE LESSEY
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Patent number: 5854401Abstract: Methods for detecting receptivity of mammalian endometrium to embryo implantation comprising obtaining a sample of the endometrium, contacting the endometrium with a monoclonal antibody for .beta..sub.3 and detecting .beta..sub.3 in the endometrium. The invention also provides for methods of diagnosing infertility in a mammal and methods of detecting the window of embryo implantation in endometrium. Methods of in vitro fertilization, methods of preventing embryo implantation and a method of monitoring endometrial maturation are also within the scope of the present invention. The present invention is also directed to contraceptives. Diagnostic kits useful in the practice of the methods of the invention are also provided.Type: GrantFiled: September 3, 1996Date of Patent: December 29, 1998Assignee: The Trustees of the University of PennsylvaniaInventor: Bruce Lessey
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Patent number: 5578306Abstract: Methods for detecting receptivity of mammalian endometrium to embryo implantation comprising obtaining a sample of the endometrium, contacting the endometrium with a monoclonal antibody for .beta..sub.3 and detecting .beta..sub.3 in the endometrium. The invention also provides for methods of diagnosing infertility in a mammal and methods of detecting the window of embryo implantation in endometrium. Methods of in vitro fertilization, methods of preventing embryo implantation and a method of monitoring endometrial maturation are also within the scope of the present invention. The present invention is also directed to contraceptives. Diagnostic kits useful in the practice of the methods of the invention are also provided.Type: GrantFiled: March 3, 1995Date of Patent: November 26, 1996Assignee: The Trustees of the University of PennsylvaniaInventor: Bruce Lessey
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Patent number: 5478725Abstract: Methods of screening for endometriosis comprise obtaining a sample of endometrium selected from menstrual cycle day 20 to 24, identifying the endometrial sample as nulliparous, contacting the endometrium with a monoclonal antibody for .beta..sub.3 integrin, assaying for .beta..sub.3 integrin and correlating the absence of .beta..sub.3 integrin with endometriosis, wherein the endometrium is identified as mild/minimum endometriosis. A method of using monoclonal antibodies to screen for endometriosis is also within the scope of the invention. Methods for detecting receptivity of mammalian endometrium to embryo implantation comprising obtaining a sample of the endometrium, contacting the endometrium with a monoclonal antibody for .beta..sub.3 and detecting .beta..sub.3 in the endometrium. The invention also provides for methods of diagnosing infertility in a mammal and methods of detecting the window of embryo implantation in endometrium.Type: GrantFiled: November 19, 1993Date of Patent: December 26, 1995Assignee: University of PennsylvaniaInventor: Bruce A. Lessey
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Patent number: 5279941Abstract: Methods are provided for detecting receptivity of mammalian endometrium to embryo implantation comprising obtaining a sample of the endometrium, contacting the endometrium with a monoclonal antibody for .beta..sub.3 integrin and detecting .beta..sub.3 integrin in the endometrium. The invention also provides for methods of diagnosing infertility in a mammal and methods of detecting the window of embryo implantation in endometrium. Methods of in vitro fertilization, methods of preventing embryo implantation and a method of monitoring endometrial maturation are also within the scope of the present invention. The present invention is also directed to contraceptives. Diagnostic kits useful in the practice of the methods of the invention are also provided.Type: GrantFiled: June 12, 1992Date of Patent: January 18, 1994Assignee: Trustees of the University of PennsylvaniaInventor: Bruce Lessey