Patents by Inventor Bruce Malcolm

Bruce Malcolm has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11548005
    Abstract: A microplate (10) includes a carrier (12) having a plate (20) and an annular perimeter wall (30) to define a recess (34). An array of holes (26) extends through the plate (20). A tape piece (16), die cut from a flexible tape (60) includes an array of wells (54) each extending through and having an opening (56) extending into the well (54). The array of wells (54) has a number and locations corresponding to the array of holes (26). The openings (56) have sizes corresponding to the holes (26). An upper surface (50) of the tape piece (16) is abutted with and bonded to the bottom face (24) of the plate (20) with the openings (56) corresponding to the array of holes (26). The slideable receipt of an annular outer periphery (58) of the tape piece (16) insures that the array of wells (54) are aligned to correspond to the array of holes (26) as die cutting of tape piece (16) insures that the array of wells (54) are at consistent positions relative to the annular outer periphery (58).
    Type: Grant
    Filed: January 8, 2019
    Date of Patent: January 10, 2023
    Assignee: DOUGLAS SCIENTIFIC, LLC
    Inventor: Bruce Malcolm Peterson
  • Publication number: 20200060972
    Abstract: Provided herein are microparticles and compositions comprising Poly(I:C) and/or polyinosinic acid (Poly I) and polycytidylic acid (Poly C) for use in preventing viral infections of the upper respiratory tract, such as human rhinovirus infection or an influenza virus infection. A nasal delivery device comprising a composition of the invention is also described.
    Type: Application
    Filed: November 15, 2017
    Publication date: February 27, 2020
    Inventors: Bruce Malcolm, Rainer Wechselberger
  • Publication number: 20190143320
    Abstract: A microplate (10) includes a carrier (12) having a plate (20) and an annular perimeter wall (30) to define a recess (34). An array of holes (26) extends through the plate (20). A tape piece (16), die cut from a flexible tape (60) includes an array of wells (54) each extending through and having an opening (56) extending into the well (54). The array of wells (54) has a number and locations corresponding to the array of holes (26). The openings (56) have sizes corresponding to the holes (26). An upper surface (50) of the tape piece (16) is abutted with and bonded to the bottom face (24) of the plate (20) with the openings (56) corresponding to the array of holes (26). The slideable receipt of an annular outer periphery (58) of the tape piece (16) insures that the array of wells (54) are aligned to correspond to the array of holes (26) as die cutting of tape piece (16) insures that the array of wells (54) are at consistent positions relative to the annular outer periphery (58).
    Type: Application
    Filed: January 8, 2019
    Publication date: May 16, 2019
    Inventor: Bruce Malcolm Peterson
  • Patent number: 8051629
    Abstract: A heat tunnel for applying heated air to articles enclosed in shrink-wrap film includes at least one air supply unit; a conveyor; and a heat shroud spaced from the conveyor. The air supply unit includes a source of heated air, a fan, a heated air plenum, air ducts, and a return air plenum. Multiple air supply units can be provided along the conveyor to create a heat tunnel of desired length.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: November 8, 2011
    Assignee: Douglas Machine Inc.
    Inventors: Irvan Leo Pazdernik, Bruce Malcolm Peterson, Paul Howard Wagner, Bradley Jon VanderTuin, Richard Jerome Schoeneck
  • Publication number: 20110174435
    Abstract: A sealing station (10) includes a shell (100) having holes (106) extending between inner and outer peripheries (102, 104) and arranged in a pattern to receive wells (30) of a carrier tape (20) directed on a portion of the outer periphery (104). Spaced, raised surfaces (150) are formed on the outer periphery (104) concentrically around and corresponding to the plurality of holes (106). A press roller (130) sandwiches a seal tape (60) against the carrier tape (20) in turn sandwiched against the spaced, raised surfaces (150) of the outer periphery (104) of the shell (100) to bond the seal tape (60) to the carrier tape (20) at areas corresponding to the spaced, raised surfaces (150).
    Type: Application
    Filed: October 1, 2009
    Publication date: July 21, 2011
    Inventor: Bruce Malcolm Peterson
  • Publication number: 20100236196
    Abstract: A heat tunnel for applying heated air to articles enclosed in shrink-wrap film includes at least one air supply unit; a conveyor; and a heat shroud spaced from the conveyor. The air supply unit includes a source of heated air, a fan, a heated air plenum, air ducts, and a return air plenum. Multiple air supply units can be provided along the conveyor to create a heat tunnel of desired length.
    Type: Application
    Filed: December 18, 2009
    Publication date: September 23, 2010
    Inventors: Irvan Leo Pazdernik, Bruce Malcolm Peterson, Paul Howard Wagner, Bradley Jon VanderTuin, Richard Jerome Schoeneck
  • Patent number: 7328550
    Abstract: A method for enclosing articles in heat-shrink film and for perforating or slitting the heat shrink film.
    Type: Grant
    Filed: July 20, 2005
    Date of Patent: February 12, 2008
    Assignee: Douglas Machine Inc.
    Inventors: Daniel Leonard Floding, Richard Jerome Schoeneck, Irvan Leo Pazdernick, Ronald Matthew Gust, Bruce Malcolm Peterson
  • Publication number: 20070274951
    Abstract: Disclosed are medicaments, pharmaceutical compositions, pharmaceutical kits, and methods based on combinations of at least one HCV protease inhibitor and at least one HCV polymerase inhibitor but not HCV-796; for concurrent or consecutive administration in treating or ameliorating one or more symptoms of HCV, or disorders associated with HCV in a subject in need thereof.
    Type: Application
    Filed: February 9, 2007
    Publication date: November 29, 2007
    Inventors: Xiao Tong, Bruce Malcolm, Hsueh-Cheng Huang
  • Publication number: 20070237818
    Abstract: Controlled-release dosage formulations including at least one compound of Formulae I to XXVIII herein and a controlled-release carrier and methods of treatment using the same are provided.
    Type: Application
    Filed: December 7, 2006
    Publication date: October 11, 2007
    Inventors: Bruce Malcolm, Wing-Kee Cho, Kevin Alton, Zhihui Qiu, Jiansheng Wan, David Monteith
  • Publication number: 20070224167
    Abstract: Novel hepatitis C virus (“HCV”) inhibitor combinations comprising an HCV protease inhibitor and HCV polymerase inhibitor, and optionally one or more biologically active agents, as well as uses of these combinations as HCV inhibitors and for treating hepatitis C and related disorders are disclosed.
    Type: Application
    Filed: February 9, 2007
    Publication date: September 27, 2007
    Applicants: Schering Corporation, ViroPharma Incorporated, Wyeth
    Inventors: Emillo Emini, Michael Flint, Anita Howe, Bruce Malcolm, Stanley Mullen, Robert Ralston, Xiao Tong
  • Patent number: 7269929
    Abstract: A heat tunnel for applying heated air to articles enclosed in shrink-wrap film includes at least one air supply unit; a conveyor; and a heat shroud spaced from the conveyor. The air supply unit includes a source of heated air, a fan, a heated air plenum, air ducts, and a return air plenum. Multiple air supply units can be provided along the conveyor to create a heat tunnel of desired length.
    Type: Grant
    Filed: July 31, 2006
    Date of Patent: September 18, 2007
    Assignee: Douglas Machine Inc
    Inventors: Bradley Jon VanderTuin, Richard Jerome Schoeneck, Irvan Leo Pazdernik, Bruce Malcolm Peterson, Paul Howard Wagner
  • Publication number: 20070099273
    Abstract: The present application relates to methods for growing crystals of both the uncomplexed and complexed forms of ?-secretase (BACE) polypeptide. The present application also relates to crystalline forms of uncomplexed BACE and the three-dimensional structure of BACE, as determined from the crystals. In addition, the present application relates to the use of crystalline forms of BACE to identify ligands, preferably inhibitors (antagonists), which bind to, and preferably inhibit the enzymatic activity of, BACE. Furthermore, the present application relates to nucleic acid sequences encoding BACE polypeptide, and methods for making BACE in greater quantity than prior methods, resulting in more effective crystallization.
    Type: Application
    Filed: December 6, 2006
    Publication date: May 3, 2007
    Inventors: Brian Beyer, Bruce Malcolm, Corey Strickland, Wenyan Wang, Eileen Wilson
  • Publication number: 20070010431
    Abstract: Pharmaceutical formulations containing at least one compound of Formulae I-XXVI herein and at least one surfactant. Pharmaceutically acceptable carriers and excipients may also be included in the formulations. The formulations of the present invention are suited for use in single unit dosages.
    Type: Application
    Filed: May 31, 2006
    Publication date: January 11, 2007
    Inventors: Bruce Malcolm, Prudence Bradley, Anastasia Pavlovsky, Wing-Kee Cho, Zhihui Qiu
  • Publication number: 20070004635
    Abstract: A method of treating, preventing or ameliorating one or more symptoms associated with hepatitis C virus (HCV) in a patient in whom either the HCV is of Genotype 1 and/or the patient was previously treated with interferon and the previous interferon therapy was ineffective to treat the one or more symptoms associated with HCV, comprising administering to such a patient an effective amount of at least one compound of formulae I-XXVI of which the following structural formula is exemplary or a pharmaceutically acceptable salt, solvate or ester thereof. Optional combined administration of said at least one compound with an interferon or pegylated interferon and/or ribaviron is also contemplated.
    Type: Application
    Filed: May 31, 2006
    Publication date: January 4, 2007
    Inventors: Janice Albrecht, Mark Laughlin, Bruce Malcolm
  • Patent number: 7155876
    Abstract: A heat tunnel for applying heated air to articles enclosed in shrink-wrap film includes at least one air supply unit; a conveyor; and a heat shroud spaced from the conveyor. Tha air supply unit includes a source of heated air, a fan, a heated air plenum, air ducts, and a return air plenum. Multiple air supply units can be provided along the conveyor to create a heat tunnel of desired length.
    Type: Grant
    Filed: October 7, 2003
    Date of Patent: January 2, 2007
    Assignee: Douglas Machine, Inc.
    Inventors: Bradley Jon VanderTuin, Richard Jerome Schoeneck, Irvan Leo Pazdernik, Bruce Malcolm Peterson, Paul Howard Wagner
  • Publication number: 20060287248
    Abstract: A method of treating, preventing or ameliorating one or more symptoms of hepatitis C, or inhibiting cathepsin activity, in a subject is provided, in which at least one compound (e.g., a HCV protease inhibitor) is administered in one or more discrete dosages over a twenty-four hour time interval in an asymmetric pattern as to dosage amount and/or timing of dosage, wherein the at least one compound is selected from the group consisting of compounds of Formulae I-XXVI, described herein. Methods of modulating the activity of hepatitis C virus protease in a subject are also provided. Asymmetric dosing as to amount of dose and/or timing of dose permits adjustment of dosing to accommodate variations in drug metabolism and/or viral activity caused by viral cell division or a patient's circadian rhythms, thus delivering the maximum amount of dose at the time or times it is most effective.
    Type: Application
    Filed: May 31, 2006
    Publication date: December 21, 2006
    Inventor: Bruce Malcolm
  • Publication number: 20060281689
    Abstract: Methods are provided for using at least one novel hepatitis C (“HCV”) protease inhibitor in combination with at least one antiviral and/or immunomodulatory agent, which is different from the at least one HCV protease inhibitor, for treating a wide variety of diseases or disorders associated with hepatitis C virus by modulating the activity of HCV protease (for example HCV NS3/NS4a serine protease) and reducing HCV viral load in a subject in a reduced treatment period. With the present invention, a hepatitis C viral load is reduced in a subject to a concentration of less than 6×10?5 HCV virions per milliliter of plasma in a time period of less than or equal to about 24 weeks. With the present invention, a hepatitis C viral production is suppressed with an effectiveness in a range of 0.7 to 0.997.
    Type: Application
    Filed: May 31, 2006
    Publication date: December 14, 2006
    Inventor: Bruce Malcolm
  • Publication number: 20060276406
    Abstract: Methods for preventing, ameliorating or treating one or more symptoms of Hepatitis C virus (HCV), modulating HCV protease activity and/or inhibiting cathepsin activity in a subject, wherein the methods comprise administering to a subject in need of such treatment a dosage formulation containing at least one compound of Formulae I-XXVI herein, wherein the dosage formulation is capable of maintaining an average Cmin plasma concentration of the compound at or above 10 ng/ml.
    Type: Application
    Filed: May 31, 2006
    Publication date: December 7, 2006
    Inventors: Samir Gupta, Bruce Malcolm
  • Publication number: 20060275366
    Abstract: Controlled-release dosage formulations including at least one compound of Formulae I to XXVI herein and a controlled-release carrier and methods of treatment using the same are provided.
    Type: Application
    Filed: May 31, 2006
    Publication date: December 7, 2006
    Inventors: Bruce Malcolm, Prudence Bradley, Wing-Kee Cho, Zhihui Qiu
  • Publication number: 20060252698
    Abstract: The present invention provides methods of inhibiting cathepsin activity in a subject in need thereof comprising administering to said subject an effective amount of at least one compound of various formulae (e.g., formula I-XXVI) disclosed herein. The present invention also provides methods of treatment of various diseases utilizing the foregoing compounds.
    Type: Application
    Filed: April 20, 2006
    Publication date: November 9, 2006
    Inventor: Bruce Malcolm