Patents by Inventor Bruce Michael Applegate

Bruce Michael Applegate has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for Generation of Reporter Phages and Immobilization of Active Bacteriophages on a Polymer Surface
    Publication number: 20120184012
    Abstract: Novel reporter bacteriophages are provided. Provided are compositions and methods that allow bacteriophages that are used for specific detection or killing of E. coli 0157:H7 to be propagated in nonpathogenic E. coli, thereby eliminating the safety and security risks of propagation in E. coli 0157:H7. Provided are compositions and methods for attaching active bacteriophages to the surface of a polymer in order to kill target bacteria with which the phage comes into contact. Provided are modified bacteriophages immobilized to a surface, which capture E. coli 0157:H7 and cause the captured cells to emit light or fluorescence, allowing detection of the bacteria in a sample.
    Type: Application
    Filed: January 19, 2012
    Publication date: July 19, 2012
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventors: Bruce Michael Applegate, Lynda Louise Perry, Mark Thomas Morgan, Aparna Kothapalli
  • Methods for generation of reporter phages and immobilization of active bacteriophages on a polymer surface
    Patent number: 8114622
    Abstract: Novel reporter bacteriophages are provided. Provided are compositions and methods that allow bacteriophages that are used for specific detection or killing of E. coli 0157:H7 to be propagated in nonpathogenic E. coli, thereby eliminating the safety and security risks of propagation in E. coli 0157:H7. Provided are compositions and methods for attaching active bacteriophages to the surface of a polymer in order to kill target bacteria with which the phage comes into contact. Provided are modified bacteriophages immobilized to a surface, which capture E. coli 0157:H7 and cause the captured cells to emit light or fluorescence, allowing detection of the bacteria in a sample.
    Type: Grant
    Filed: August 28, 2009
    Date of Patent: February 14, 2012
    Assignee: Purdue Research Foundation
    Inventors: Bruce Michael Applegate, Lynda Louise Perry, Mark Thomas Morgan, Aparna Kothapalli
  • Methods for Generation of Reporter Phages and Immobilization of Active Bacteriophages on a Polymer Surface
    Publication number: 20100075301
    Abstract: Novel reporter bacteriophages are provided. Provided are compositions and methods that allow bacteriophages that are used for specific detection or killing of E. coli 0157:H7 to be propagated in nonpathogenic E. coli, thereby eliminating the safety and security risks of propagation in E. coli 0157:H7. Provided are compositions and methods for attaching active bacteriophages to the surface of a polymer in order to kill target bacteria with which the phage comes into contact. Provided are modified bacteriophages immobilized to a surface, which capture E. coli 0157:H7 and cause the captured cells to emit light or fluorescence, allowing detection of the bacteria in a sample.
    Type: Application
    Filed: August 28, 2009
    Publication date: March 25, 2010
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventors: Bruce Michael Applegate, Lynda Louise Perry, Mark Thomas Morgan, Aparna Kothapalli