Patents by Inventor Bruce Mico

Bruce Mico has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Carbamates of 6-chloro-7,8-dihydroxy-1-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benz azepine as prodrugs
    Patent number: 4861771
    Abstract: Prodrug carbamate derivatives of fenoldopam which provide fenoldopam plasma levels of similar magnitude and over a much longer period of time than the parent compound. An absence of a high initial peak effect associated with the parent compound is noted. A lead compound of the series is 6-chloro-7,8-diethylcarbamoyl-1-(4'-ethylcarbamoylphenyl)-2,3,4,5-tetrahyd ro-1H-3-benzazepine. The R-enantiomers are the most biologically active and preferred compounds.
    Type: Grant
    Filed: January 27, 1989
    Date of Patent: August 29, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: Dimitri Gaitanopoulos, Bruce Mico, Joseph Weinstock