Patents by Inventor Bruce N. Ames

Bruce N. Ames has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7964587
    Abstract: Anti-inflammatory compositions include medicaments comprising predetermined amounts of a phytyl substituted chromanol and a prostaglandin E2 inhibitor, wherein: said medicament is in unit dosage form suitable for pharmaceutical administration; said phytyl substituted chromanol is a gamma-tocopherol, delta-tocopherol, gamma-tocotrienol or delta-tocotrienol; said PGE2 inhibitor is a non-steroidal anti-inflammatory drug or an omega-3 fatty acid, such as docosahexaenoic acid and eicosapentaenoic acid.
    Type: Grant
    Filed: June 22, 2005
    Date of Patent: June 21, 2011
    Assignee: Children's Hospital & Research Center at Oakland
    Inventors: Bruce N. Ames, Qing Jiang
  • Patent number: 7527978
    Abstract: The invention is a method for analyzing immature reticulocytes for the presence of micronuclei. The method includes reticulocyte enrichment, fluorescent labeling, micronuclei staining, and analysis using single-laser flow cytometry. The invention also includes kits containing reagents to use in the method.
    Type: Grant
    Filed: October 7, 2004
    Date of Patent: May 5, 2009
    Assignee: Children's Hospital & Research Center at Oakland
    Inventors: Tal Offer, Emily Ho, Bruce N. Ames, Frans Kuypers
  • Publication number: 20080268537
    Abstract: The invention provides pharmaceutical compositions comprising primary N-hydroxylamines and related therapeutic, prophylactic, diagnostic and screening methods. The pharmaceutical compositions generally comprise a pharmaceutical composition comprising an orally administrable effective unit solid dosage of a primary N-hydroxylamine or a pharmaceutically acceptable salt thereof and substantially free of a nitrone corresponding to the hydroxylamine.
    Type: Application
    Filed: July 7, 2008
    Publication date: October 30, 2008
    Applicant: The Regents of the University of California
    Inventors: Bruce N. Ames, Hani Atamna
  • Patent number: 7399784
    Abstract: Anti-obesity compositions include medicaments comprising predetermined amounts of a phytyl substituted chromanol and an obesity-promoting drug, wherein: said medicament is in unit dosage form suitable for pharmaceutical administration; said phytyl substituted chromanol is a gamma-tocopherol, delta-tocopherol, alpha-tocotrienol, gamma-tocotrienol or delta-tocotrienol; said obesity-promoting drug is a corticosteroid or an anti-diabetes drug such as a hypoglycemic drug, starch blocker, glucose production blocker or insulin sensitizer.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: July 15, 2008
    Assignee: Children's Hospital & Research Center at Oakland
    Inventors: Bruce N. Ames, Qing Jiang
  • Patent number: 7030154
    Abstract: A method of stabilizing R-?-lipoic acid includes combining R-?-lipoic acid with nicotinamide in a weight ratio between about 10:4 to about 10:8. A composition for treating oxidative stress includes R-?-lipoic acid and nicotinamide in a weight ratio of between about 10:4 and about 10:8.
    Type: Grant
    Filed: June 5, 2003
    Date of Patent: April 18, 2006
    Assignee: Juvenon, Inc.
    Inventor: Bruce N. Ames
  • Patent number: 7026338
    Abstract: Pharmaceutical nitrone comprise condensates of an N-hydroxylamine and a physiological aldehyde, providing improved delivery and absorption, enhanced stability and reduced toxicity. Preferred physiological aldehydes are subject to endogenous cellular uptake transport, and include pyridoxal, pyridoxal phosphate, and heme-A. Essentially any physiologically compatible and pharmaceutically active hydroxylamine moiety may be incorporated, such as hydroxylamine moieties of prior pharmaceutical nitrones, and known pharmaceutically active hydroxylamines.
    Type: Grant
    Filed: May 11, 2004
    Date of Patent: April 11, 2006
    Assignee: Children's Hospital Research Center at Oakland
    Inventors: Bruce N. Ames, Hani Atamna
  • Publication number: 20040110729
    Abstract: The invention provides pharmaceutical compositions comprising primary N-hydroxylamines and related therapeutic, prophylactic, diagnostic and screening methods. The pharmaceutical compositions generally comprise a pharmaceutical composition comprising an orally administrable effective unit solid dosage of a primary N-hydroxylamine or a pharmaceutically acceptable salt thereof and substantially free of a nitrone corresponding to the hydroxylamine.
    Type: Application
    Filed: November 25, 2003
    Publication date: June 10, 2004
    Inventors: Bruce N. Ames, Hani Atamna
  • Publication number: 20040102420
    Abstract: The invention provides pharmaceutical compositions comprising primary N-hydroxylamines and related therapeutic, prophylactic, diagnostic and screening methods. The pharmaceutical compositions generally comprise a pharmaceutical composition comprising an orally administrable effective unit solid dosage of a primary N-hydroxylamine or a pharmaceutically acceptable salt thereof and substantially free of a nitrone corresponding to the hydroxylamine.
    Type: Application
    Filed: November 13, 2003
    Publication date: May 27, 2004
    Inventors: Bruce N. Ames, Hani Atamna
  • Publication number: 20040102385
    Abstract: Anti-obesity compositions include medicaments comprising predetermined amounts of a phytyl substituted chromanol and an obesity-promoting drug, wherein: said medicament is in unit dosage form suitable for pharmaceutical administration; said phytyl substituted chromanol is a gamma-tocopherol, delta-tocopherol, alpha-tocotrienol, gamma-tocotrienol or delta-tocotrienol; said obesity-promoting drug is a corticosteroid or an anti-diabetes drug such as a hypoglycemic drug, starch blocker, glucose production blocker or insulin sensitizer.
    Type: Application
    Filed: November 26, 2002
    Publication date: May 27, 2004
    Applicant: Children's Hospital Research Center at Oakland
    Inventors: Bruce N. Ames, Qing Jiang
  • Publication number: 20040102421
    Abstract: Anti-inflammatory compositions include medicaments comprising predetermined amounts of a phytyl substituted chromanol and a prostaglandin E2 inhibitor, wherein: said medicament is in unit dosage form suitable for pharmaceutical administration; said phytyl substituted chromanol is a gamma-tocopherol, delta-tocopherol, gamma-tocotrienol or delya-tocotrienol; said PGE2 inhibitor is a non-steroidal anti-inflammatory drug or an omega-3 fatty acid, such as docosahexaenoic acid and eicosapentaenoic acid.
    Type: Application
    Filed: November 21, 2002
    Publication date: May 27, 2004
    Applicant: Children's Hospital Research Center at Oakland
    Inventors: Bruce N. Ames, Qing Jiang
  • Publication number: 20040044046
    Abstract: A method of stabilizing R-&agr;-lipoic acid includes combining R-&agr;-lipoic acid with nicotinamide in a weight ratio between about 10:4 to about 10:8. A composition for treating oxidative stress includes R-&agr;-lipoic acid and nicotinamide in a weight ratio of between about 10:4 and about 10:8.
    Type: Application
    Filed: June 5, 2003
    Publication date: March 4, 2004
    Inventor: Bruce N. Ames
  • Publication number: 20030153535
    Abstract: The invention provides pharmaceutical compositions comprising primary N-hydroxylamines and related therapeutic, prophylactic, diagnostic and screening methods. The pharmaceutical compositions generally comprise a pharmaceutical composition comprising an orally administrable effective unit solid dosage of a primary N-hydroxylamine or a pharmaceutically acceptable salt thereof and substantially free of a nitrone corresponding to the hydroxylamine.
    Type: Application
    Filed: October 20, 2001
    Publication date: August 14, 2003
    Applicant: The Regents of the University of California
    Inventors: Bruce N. Ames, Hani Atamna
  • Patent number: 6455589
    Abstract: The invention provides pharmaceutical compositions comprising primary N-hydroxylamines and related therapeutic, prophylactic, diagnostic and screening methods. The pharmaceutical compositions generally comprise a pharmaceutical composition comprising an orally administrable effective unit solid dosage of a primary N-hydroxylamine or a pharmaceutically acceptable salt thereof and substantially free of a nitrone corresponding to the hydroxylamine.
    Type: Grant
    Filed: October 28, 1999
    Date of Patent: September 24, 2002
    Assignee: The Regents of the University of California
    Inventors: Bruce N. Ames, Hani Atamna
  • Patent number: 5916912
    Abstract: The metabolic rate of aged cells of a mammalian host is enhanced without a concomitant increase in metabolic production of reactive oxygen species by orally administering to the host an effective dosage of a carnitine, such as acetyl-L-carnitine, and a mitochondrially active antioxidant, such as lipoic acid.
    Type: Grant
    Filed: June 16, 1997
    Date of Patent: June 29, 1999
    Assignee: The Regents of the University of California
    Inventors: Bruce N. Ames, Tory M. Hagen
  • Patent number: 5869258
    Abstract: Six sets of Salmonella typhimurium strains are provided, all strains having low spontaneous mutation rates, and each set being sensitive to and diagnostic of one of the six possible base substitutions in DNA. Also provided are methods for making and using these S. typhimurium strains to detect, and establish the type of specific base substitution mutation induced by, mutagenic agents.
    Type: Grant
    Filed: May 28, 1997
    Date of Patent: February 9, 1999
    Assignee: The Regents of the University of California
    Inventors: Pauline Gee, Dorothy M. Maron, Bruce N. Ames
  • Patent number: 5681737
    Abstract: Six sets of Salmonella typhimurium strains are provided, all strains having low spontaneous mutation rates, and each set being sensitive to and diagnostic of one of the six possible base substitutions in DNA. Also provided are methods for making and using these S. typhimurium strains to detect, and establish the type of specific base substitution mutation induced by, mutagenic agents.
    Type: Grant
    Filed: October 15, 1993
    Date of Patent: October 28, 1997
    Assignee: The Regents of the University of California
    Inventors: Pauline Gee, Dorothy M. Maron, Bruce N. Ames