Abstract: This invention provides implantable medical devices having at least one moiety attached to the surface capable of catalyzing a reaction in vivo. The implantable medical device has a body such as a stent with a surface adapted to be placed adjacent to a biological tissue or fluid. The body has at least one moiety attached to the surface which is capable of catalyzing a first reaction upon contacting a first substrate in the biological tissue or fluid. The moiety remains attached to the surface after the first reaction and is capable of catalyzing at least a second reaction upon contacting a second substrate. In preferred embodiments the moiety is capable of catalyzing a multitude of reactions as substrates come into contact and then leave the surface of the device.

Abstract: This invention is designed to help restrain small structural or minor fracture fragments (5), and the macromolecules they produce (8) in specified compartment. The device is composed of a single sheet of material (1) that in its principal embodiment is supplied as a thin, pliable, fabric that is flexible in three dimensions and is minimally porous to macromolecules. When the method of use contains the secondary step of affixing a treating material (12) to the device prior to use, additional materials can be delivered directly and preferentially into specific compartments. Moreover, because the device can be made of a soft fabric, a needle can be passed through the device and additional treating materials can be repeatedly injected into and contained after the device has been deployed. The invention also permits delivery of energy (23)directly and specifically to the treated surface.

Abstract: The invention and the corresponding method of fracture stabilization provided is a malleable medication-containing device that is capable of both stabilizing fracture fragments and delivering medicines directly to fracture fragments when wrapped around or affixed to fractured tissues. This invention is designed to be used in conjunction with rigid fixation devices when rigid fixation is required of the major fragments. The novel device is comprised of two layers affixed to each other by chemical or mechanical means: a flexible, minimally-porous biologically-compatible fabric and a flexible biologically-compatible microporous polymer into which desired medications have been embedded. The preferred method of employment is to wrap the device around a fracture with the medication side in; and tighten it until the desired tension is achieved, thereby holding native fracture fragments in register.