Patents by Inventor Bruce Pearce

Bruce Pearce has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYSTEM FOR MAGNETIC RESONANCE SPECTROSCOPY OF BRAIN TISSUE FOR PATTERN-BASED DIAGNOSTICS
    Publication number: 20150065853
    Abstract: A system and method for preprocessing magnetic resonance spectroscopy (MRS) data of brain tissue for pattern-based diagnostics is disclosed. The MRS preprocessing system includes an MRS preprocessing module that executes an operation that normalizes MRS spectrum data, recalibrates and scales the normalized MRS spectrum data, and then renormalizes the scaled MRS spectrum data. The resulting preprocessed MRS data is used to assist in identifying abnormalities in tissues shown in MRS scans.
    Type: Application
    Filed: September 5, 2014
    Publication date: March 5, 2015
    Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Jon G. Wilkes, Dan A. Buzatu, Pierre Alusta, Bruce Pearce, Ryan M. Kretzer, Inessa IM, Richard D. Beger
  • System for magnetic resonance spectroscopy of brain tissue for pattern-based diagnostics
    Patent number: 8880354
    Abstract: A system and method for preprocessing magnetic resonance spectroscopy (MRS) data of brain tissue for pattern-based diagnostics is disclosed. The MRS preprocessing system includes an MRS preprocessing module that executes an operation that normalizes MRS spectrum data, recalibrates and scales the normalized MRS spectrum data, and then renormalizes the scaled MRS spectrum data. The resulting preprocessed MRS data is used to assist in identifying abnormalities in tissues shown in MRS scans.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: November 4, 2014
    Assignee: The United States of America, as Represented by the Secretary, Department of Health and Human Services
    Inventors: Jon G. Wilkes, Dan A. Buzatu, Pierre Alusta, Bruce Pearce, Ryan M. Kretzer, Inessa Im, Richard D. Beger
  • SYSTEM FOR MAGNETIC RESONANCE SPECTROSCOPY OF BRAIN TISSUE FOR PATTERN-BASED DIAGNOSTICS
    Publication number: 20130131992
    Abstract: A system and method for preprocessing magnetic resonance spectroscopy (MRS) data of brain tissue for pattern-based diagnostics is disclosed. The MRS preprocessing system includes an MRS preprocessing module that executes an operation that normalizes MRS spectrum data, recalibrates and scales the normalized MRS spectrum data, and then renormalizes the scaled MRS spectrum data. The resulting preprocessed MRS data is used to assist in identifying abnormalities in tissues shown in MRS scans.
    Type: Application
    Filed: November 12, 2010
    Publication date: May 23, 2013
    Applicant: The Government USA as Represented by the Secretary Dept. of Health and Human Services
    Inventors: Jon G. Wilkes, Dan A. Buzatu, Pierre Alusta, Bruce Pearce, Ryan M. Kretzer, Inessa Im, Richard D. Beger
  • Compositions and methods for chemodenervation using neurotoxins
    Patent number: 6087327
    Abstract: The compositions and methods disclosed herein utilize admixtures of neurotoxins to cause denervation which is unexpectedly more localized and of longer duration than otherwise occurs with single neurotoxins. The compositions and methods of the invention utilize neurotoxin admixtures calibrated in median paralysis units rather than LD.sub.50 s. Admixtures of neurotoxins include, but are not limited to, the botulinum serotypes A-G and tetanus toxin. The clinical benefits of the disclosed invention include: lengthening intervals between neurotoxin treatments; reducing adverse immunogenic responses to neurotoxins; and, reducing adverse diffusion-dependent side-effects of neurotoxin treatments.
    Type: Grant
    Filed: January 30, 1998
    Date of Patent: July 11, 2000
    Inventors: L. Bruce Pearce, Eric R. First