Abstract: An example medical device and method of use is disclosed. An example medical device includes a catheter having a distal end region, a proximal end region and a lumen extending therein. The medical device further includes a tip member disposed along the distal end region, the tip member extending radially inward from a wall surface of the catheter. The medical device further includes an inner member slidably disposed within the lumen of the catheter, the inner member having a first lumen, a second lumen, a mixing region, and a distally extending member, wherein an opening is defined in a central region of the tip member, and wherein the distally extending member is designed to extend through the opening.

Abstract: A collapsible treatment device (81) for treating a target area of a vessel wall within a human or animal body, having a mesh portion, preferably annular in shape (82) and with a contracted configuration allowing travel within the vessel to the target area and an expanded configuration allowing treatment of the target area. A treatment implement is on the mesh portion and protuberance either as part of the mesh or provided on a sheath which protects the vessel from contact with the implement during travel within the vessel.