Patents by Inventor Bruce R. Ksander

Bruce R. Ksander has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AAV2-MEDIATED GENE DELIVERY OF SFASL AS A NEUROPROTECTIVE THERAPY IN GLAUCOMA
    Publication number: 20250001015
    Abstract: Methods for treating glaucoma and/or Fas ligand-dependent inflammatory conditions in a subject using soluble Fas ligand (sFasL) or a fragment thereof, which may be rAAV-mediated delivery of sFasL or a fragment thereof to a subject.
    Type: Application
    Filed: March 5, 2024
    Publication date: January 2, 2025
    Applicants: University of Massachusetts, Massachusetts Eye and Ear Infirmary
    Inventors: Ann Marshak-Rothstein, Meredith Gregory-Ksander, Bruce R. Ksander
  • Tumor cells from immune privileged sites as base cells for cell-based cancer vaccines
    Patent number: 8444965
    Abstract: The present invention relates to tumor cell-based vaccines and methods of using same, wherein the vaccines are based on naturally immune privileged tumor cells that have been genetically modified to express MHC-II restricted peptides derived from endogenously encoded tumor antigens, activate CD4+ T-lymphocytes, provide an array of antigens to which the host is not tolerized and/or induce immunity against the originating tumor cells as well as against metastatic tumor cells.
    Type: Grant
    Filed: September 23, 2010
    Date of Patent: May 21, 2013
    Assignee: University of Maryland, Baltimore County
    Inventors: Suzanne Ostrand-Rosenberg, Jacobus J. Bosch, Bruce R. Ksander
  • TUMOR CELLS FROM IMMUNE PRIVILEGED SITES AS BASE CELLS FOR CELL-BASED CANCER VACCINES
    Publication number: 20110165187
    Abstract: The present invention relates to tumor cell-based vaccines and methods of using same, wherein the vaccines are based on naturally immune privileged tumor cells that have been genetically modified to express MHC-II restricted peptides derived from endogenously encoded tumor antigens, activate CD4+ T-lymphocytes, provide an array of antigens to which the host is not tolerized and/or induce immunity against the originating tumor cells as well as against metastatic tumor cells.
    Type: Application
    Filed: September 23, 2010
    Publication date: July 7, 2011
    Inventors: Suzanne Ostrand-Rosenberg, Jacobus J. Bosch, Bruce R. Ksander
  • Tumor cells from immune privileged sites as base cells for cell-based cancer vaccines
    Patent number: 7807186
    Abstract: The present invention relates to tumor cell-based vaccines and methods of using same, wherein the vaccines are based on naturally immune privileged tumor cells that have been genetically modified to express MHC-II restricted peptides derived from endogenously encoded tumor antigens, activate CD4+ T-lymphocytes, provide an array of antigens to which the host is not tolerized and/or induce immunity against the originating tumor cells as well as against metastatic tumor cells.
    Type: Grant
    Filed: January 16, 2008
    Date of Patent: October 5, 2010
    Assignee: University of Maryland, Baltimore County
    Inventors: Suzanne Ostrand-Rosenberg, Jacobus J. Bosch, Bruce R. Ksander
  • TUMOR CELLS FROM IMMUNE PRIVILEGED SITES AS BASE CELLS FOR CELL-BASED CANCER VACCINES
    Publication number: 20080206288
    Abstract: The present invention relates to tumor cell-based vaccines and methods of using same, wherein the vaccines are based on naturally immune privileged tumor cells that have been genetically modified to express MHC-II restricted peptides derived from endogenously encoded tumor antigens, activate CD4+ T-lymphocytes, provide an array of antigens to which the host is not tolerized and/or induce immunity against the originating tumor cells as well as against metastatic tumor cells.
    Type: Application
    Filed: January 16, 2008
    Publication date: August 28, 2008
    Inventors: Suzanne Ostrand-Rosenberg, Jacobus J. Bosch, Bruce R. Ksander