Patents by Inventor Bruce R. McLeod
Bruce R. McLeod has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6146586Abstract: In order to completely sterilize all of the surfaces of a medical instrument on which biofilms are apt to form, the device is immersed in a container containing an antibiotic solution in a manner wherein all of the contaminated surfaces are forced into intimate contact with the antibiotic solution. A first current is applied to a first electrode disposed at one end of the container to establish a first current flow about the exterior of the instrument between the first electrode and a second distal electrode which is either proximate or in direct contact with an end portion of the device. A second current is passed between a third electrode which is either in electrical contact with a part of the instrument that is not immersed in the antibiotic solution, or immersed in the solution has been forced into the interior of the device, and the second electrode via a second current path which extends through the interior of the instrument.Type: GrantFiled: May 28, 1998Date of Patent: November 14, 2000Assignee: The Research and Development IntstituteInventors: Bruce R. McLeod, J. William Costerton
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Patent number: 5518496Abstract: An apparatus and method for regulating the growth of living tissue are provided. The apparatus includes a deformable magnetic field generator and a magnetic field detector for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through the target tissue. The deformable magnetic field generator includes a pair of field coils embedded in a flexible material which allows the field coils to be plastically deformed to fit the contour of a body region such as a patient's limb. The field detector samples the magnetic flux density along the predetermined access and provides a signal to a microprocessor which determines the average value of the flux density. The applied magnetic field is oscillated at predetermined frequencies to maintain a preselected ratio of frequency to average flux density.Type: GrantFiled: May 26, 1994Date of Patent: May 21, 1996Assignee: Life Resonances, Inc.Inventors: Bruce R. McLeod, Stephen D. Smith, Abraham R. Liboff
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Patent number: 5458558Abstract: An apparatus and method for regulating tissue growth in vivo are provided. The apparatus includes a magnetic field generator and a magnetic field detector for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through the target tissue. The field detector samples the magnetic flux density along the predetermined access and provides a signal to a microprocessor which determines the average value of the flux density. The applied magnetic field is oscillated at predetermined frequencies to maintain a preselected ratio of frequency to average flux density. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field as the composite magnetic flux density changes in response to changes in the local magnetic field to which the target tissue is subjected.Type: GrantFiled: October 13, 1993Date of Patent: October 17, 1995Assignee: Life Resonances, Inc.Inventors: Abraham R. Liboff, Bruce R. McLeod, Stephen D. Smith
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Patent number: 5441495Abstract: A method and apparatus for therapeutically treating stroke is provided. The apparatus includes a magnetic field generator for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through the patient's cerebral tissue. In one aspect, a field detector measures the magnetic flux density along the predetermined axis. The applied magnetic field may comprise a full-wave rectified signal oscillated at predetermined frequencies to maintain a preselected ratio of frequency to the effective flux density, where the ratio maintains tissue viability and reduces edema by controlling ion electrolyte balance. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field after nulling out the local magnetic field at that region containing the target cerebral tissue.Type: GrantFiled: October 13, 1993Date of Patent: August 15, 1995Assignee: Life Resonances, Inc.Inventors: Abraham R. Liboff, Bruce R. McLeod, Stephen D. Smith
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Patent number: 5437600Abstract: A method and apparatus for therapeutically treating cancer is provided. The apparatus includes a magnetic field generator for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through a malignant neoplasm. In one aspect, a field detector measures the magnetic flux density along the predetermined axis. The applied magnetic field may comprise a full-wave rectified signal oscillated at predetermined frequencies to maintain a preselected ratio of frequency to the effective flux density, where the ratio regulates the growth characteristics of cancer cells of the neoplasm. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field after nulling out the local magnetic field at that region containing the neoplasm.Type: GrantFiled: June 27, 1994Date of Patent: August 1, 1995Assignee: Life Resonances, Inc.Inventors: Abraham R. Liboff, Bruce R. McLeod, Stephen D. Smith
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Patent number: 5376245Abstract: A portable magnetic field analyzer for sensing ion specific resonant magnetic fields. The analyzer has a magnetometer which measures the magnetic field produced by both ac and dc sources along an axis and determines the dc field plus the fundamental and various harmonic frequencies. A microcontroller uses this information to calculate various cyclotron resonance frequencies and then compares the calculations to stored data relating to cyclotron resonance frequencies of certain biologically important ions such as calcium, potassium and magnesium. A display notifies the user when resonance conditions (within a set tolerance) exist.Type: GrantFiled: October 28, 1993Date of Patent: December 27, 1994Assignee: Life Resonances, Inc.Inventor: Bruce R. McLeod
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Patent number: 5318561Abstract: An apparatus and method for regulating the growth of living tissue are provided. The apparatus includes a deformable magnetic field generator and a magnetic field detector for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through the target tissue. The deformable magnetic field generator includes a pair of field coils embedded in a flexible material which allows the field coils to be plastically deformed to fit the contour of a body region such as a patient's limb. The field detector samples the magnetic flux density along the predetermined access and provides a signal to a microprocessor which determines the average value of the flux density. The applied magnetic field is oscillated at predetermined frequencies to maintain a preselected ratio of frequency to average flux density.Type: GrantFiled: February 18, 1992Date of Patent: June 7, 1994Assignee: Life Resonances Inc.Inventors: Bruce R. McLeod, Stephen D. Smith, Abraham R. Liboff
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Patent number: 5316634Abstract: A portable magnetic field analyzer for sensing ion specific resonant magnetic fields. The analyzer has a magnetometer which measures the magnetic field produced by both ac and dc sources along an axis and determines the dc field plus the fundamental and various harmonic frequencies. A microcontroller uses this information to calculate various cyclotron resonance frequencies and then compares the calculations to stored data relating to cyclotron resonance frequencies of certain biologically important ions such as calcium, potassium and magnesium. A display notifies the user when resonance conditions (within a set tolerance) exist.Type: GrantFiled: June 16, 1992Date of Patent: May 31, 1994Assignee: Life Resonances, Inc.Inventor: Bruce R. McLeod
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Patent number: 5312534Abstract: A method is provided for enhancing the transport of a selected ion having a predetermined charge-to-mass ratio through a biomolecular membrane located in a space subjected to a local magnetic field. The space defines at least one reference path passing through the membrane in opposite first and second directions. The method includes the steps of creating a magnetic field which, when combined with the local magnetic field, produces a magnetic field having a flux density with at least one component representable by a component vector having a direction extending in the first direction along the path. This component of the magnetic field has a magnitude that fluctuates at a predetermined rate to produce a nonzero average value. A predetermined relationship between the ratio of the selected rate to the nonzero average value and the charge-to-mass ratio of the predetermined ion is thereby created. The predetermined relationship, is a function of the cyclotron resonance frequency of the ion.Type: GrantFiled: December 7, 1988Date of Patent: May 17, 1994Inventors: Abraham R. Liboff, Bruce R. McLeod, Steven D. Smith
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Patent number: 5290409Abstract: Methods and apparatus for regulating ion movement across biological membranes are provided. In one aspect, harmonic frequencies of a fluctuating magnetic field based on cyclotron resonance principles are provided for selectively enhancing transmembrane ion movement. In another aspect, a method and apparatus are provided for simultaneously regulating the transmembrane movement of multiple distinct ionic species using a fluctuating magnetic field. Therapeutic applications of harmonic tuning and multiple tuning are also provided.Type: GrantFiled: August 20, 1992Date of Patent: March 1, 1994Assignee: Life Resonances, Inc.Inventors: Abraham R. Liboff, Stephen D. Smith, Bruce R. McLeod
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Patent number: 5269745Abstract: An apparatus and method for regulating tissue growth in vivo are provided. The apparatus includes a magnetic field generator and a magnetic field detector for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through the target tissue. The field detector samples the magnetic flux density along the predetermined access and provides a signal to a microprocessor which determines the average value of the flux density. The applied magnetic field is oscillated at predetermined frequencies to maintain a preselected ratio of frequency to average flux density. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field as the composite magnetic flux density changes in response to changes in the local magnetic field to which the target tissue is subjected.Type: GrantFiled: April 1, 1992Date of Patent: December 14, 1993Assignee: Life Resonances, Inc.Inventors: Abraham R. Liboff, Bruce R. McLeod, Stephen D. Smith
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Patent number: 5267939Abstract: An apparatus and method for preventing and therapeutically treating osteoporosis are provided. The apparatus includes a magnetic field generator for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through the target bone or skeletal system. In one aspect, a field detector samples the magnetic flux density along the predetermined axis and provides a signal to a microprocessor which determines the average value of the flux density. The applied magnetic field is oscillated at predetermined frequencies to maintain a preselected ratio of frequency to average flux density which controls osteoporosis. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field as the composite magnetic flux density changes in response to changes in the local magnetic field to which the target bone is subjected.Type: GrantFiled: October 10, 1991Date of Patent: December 7, 1993Assignee: Life Resonances, Inc.Inventors: Abraham R. Liboff, Bruce R. McLeod, Stephen D. Smith
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Patent number: 5215642Abstract: An improved apparatus and method for regulating transmembrane ion movement through a biochemical membrane. The apparatus includes a magnetic field generator and a magnetic field detector for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through the membrane. The field detector samples the magnetic flux density along the predetermined access and provides a signal to a microprocessor which determines the average value of the flux density. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field as the composite magnetic flux density changes in response to changes in the local magnetic field to which the target membrane is subjected. By maintaining these precise predetermined ratios of frequency to average magnetic flux density, ion transport is controlled.Type: GrantFiled: October 16, 1991Date of Patent: June 1, 1993Assignee: Life Resonances, Inc.Inventors: Abraham R. Liboff, Stephen D. Smith, Bruce R. McLeod
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Patent number: 5215633Abstract: A method is provided for enhancing the transport of a selected ion having a predetermined charge-to-mass ratio through a biomolecular membrane located in a space subjected to a local magnetic field. The space defines at least one reference path passing through the membrane in opposite first and second directions. The method includes the steps of creating a magnetic field which, when combined with the local magnetic field, produces a magnetic field having a flux density with at least one component representable by a component vector having a direction extending in the first direction along the path. This component of the magnetic field has a magnitude that fluctuates at a predetermined rate to produce a nonzero average value. A predetermined relationship between the ratio of the selected rate to the nonzero average value and the charge-to-mass ratio of the predetermined ion is thereby created. The predetermined relationship, is a function of the cyclotron resonance frequency of the ion.Type: GrantFiled: December 23, 1991Date of Patent: June 1, 1993Assignee: Life Resonances, Inc.Inventors: Abraham R. Liboff, Bruce R. McLeod, Stephen D. Smith
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Patent number: 5211622Abstract: A method and apparatus for therapeutically treating cancer is provided. The apparatus includes a magnetic field generator for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through a malignant neoplasm. In one aspect, a field detector measures the magnetic flux density along the predetermined axis. The applied magnetic field may comprise a full-wave rectified signal oscillated at predetermined frequencies to maintain a preselected ratio of frequency to the effective flux density, where the ratio regulates the growth characteristics of cancer cells of the neoplasm. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field after nulling out the local magnetic field at that region containing the neoplasm.Type: GrantFiled: May 21, 1991Date of Patent: May 18, 1993Assignee: Life Resonances, Inc.Inventors: Abraham R. Liboff, Bruce R. McLeod, Stephen D. Smith
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Patent number: 5183456Abstract: A method and apparatus for therapeutically treating cancer is provided. The apparatus includes a magnetic field generator for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through a malignant neoplasm. In one aspect, a field detector measures the magnetic flux density along the predetermined axis. The applied magnetic field may comprise a full-wave rectified signal oscillated at predetermined frequencies to maintain a preselected ratio of frequency to the effective flux density, where the ratio regulates the growth characteristics of cancer cells of the neoplasm. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field after nulling out the local magnetic field at that region containing the neoplasm.Type: GrantFiled: June 23, 1992Date of Patent: February 2, 1993Assignee: Life Resonances, Inc.Inventors: Abraham R. Liboff, Bruce R. McLeod, Stephen D. Smith
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Patent number: 5160591Abstract: Methods and apparatus for regulating ion movement across biological membranes are provided. In one aspect, harmonic frequencies of a fluctuating magnetic field based on cyclotron resonance principles are provided for selectively enhancing transmembrane ion movement. In another aspect, a method and apparatus are provided for simultaneously regulating the transmembrane movement of multiple distinct ionic species using a fluctuating magnetic field. Therapeutic applications of harmonic tuning and multiple tuning are also provided.Type: GrantFiled: October 25, 1991Date of Patent: November 3, 1992Assignee: Life Resonances, Inc.Inventors: Abraham R. Liboff, Bruce R. McLeod, Stephen D. Smith
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Patent number: 5143588Abstract: A method is provided for enhancing the transport of a selected ion having a predetermined charge-to-mass ratio through a biomolecular membrane located in a space subjected to a local magnetic field. The space defines at least one reference path passing through the membrane in opposite first and second directions. The method includes the steps of creating a magnetic field which, when combined with the local magnetic field, produces a magnetic field having a flux density with at least one component representable by a component vector having a direction extending in the first direction along the path. This component of the magnetic field has a magnitude that fluctuates at a predetermined rate to produce a nonzero average value. A predetermined relationship between the ratio of the selected rate to the nonzero average value and the charge-to-mass ratio of the predetermined ion is thereby created. The predetermined relationship is a function of the cyclotron resonance frequency of the ion.Type: GrantFiled: August 2, 1990Date of Patent: September 1, 1992Assignee: Life Resonances, Inc.Inventors: Abraham R. Liboff, Bruce R. McLeod, Stephen D. Smith
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Patent number: 5123898Abstract: An apparatus and method for regulating tissue growth in vivo are provided. The apparatus includes a magnetic field generator and a magnetic field detector for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through the target tissue. The field detector samples the magnetic flux density along the predetermined access and provides a signal to a microprocessor which determines the average value of the flux density. The applied magnetic field is oscillated at predetermined frequencies to maintain a preselected ratio of frequency to average flux density. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field as the composite magnetic flux density changes in response to changes in the local magnetic field to which the target tissue is subjected.Type: GrantFiled: March 20, 1990Date of Patent: June 23, 1992Assignee: Life Resonances, Inc.Inventors: Abraham R. Liboff, Bruce R. McLeod, Stephen D. Smith
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Patent number: 5106361Abstract: An apparatus and method for regulating the growth of connective tissue proper in vivo are provided. The apparatus includes a magnetic field generator and a magnetic field detector for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through the target tissue. The field detector samples the magnetic flux density along the predetermined access and provides a signal to a microprocessor which determines the average value of the flux density. The applied magnetic field is oscillated at predetermined frequencies to maintain a preselected ratio of frequency to average flux density. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field as the composite magnetic flux density changes in response to changes in the local magnetic field to which the target tissue is subjected.Type: GrantFiled: October 6, 1988Date of Patent: April 21, 1992Assignee: Life Resonances, Inc.Inventors: Abraham R. Liboff, Bruce R. McLeod, Stephen D. Smith