Patents by Inventor Bruce Roth

Bruce Roth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF
    Publication number: 20240051945
    Abstract: The present disclosure relates to a class of pyrimidine compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, stereoisomers, solvates, and hydrates thereof. The present disclosure also relates to a process of preparation of these pyrimidine compounds, pharmaceutical compositions containing them, and medicinal applications thereof.
    Type: Application
    Filed: October 30, 2021
    Publication date: February 15, 2024
    Inventors: Gurulingappa Hallur, Naveena Madhyastha, Michael Rajesh Stephen, Bruce Roth, Anjali Pandey, Tracy Saxton, Sridharan Rajagopal, M. Naveen Sadhu
  • PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF
    Publication number: 20230416232
    Abstract: The present disclosure relates to a class of pyrimidine compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, stereoisomers, solvates, and hydrates thereof. The present disclosure also relates to a process of preparation of these pyrimidine compounds, pharmaceutical compositions containing them, and medicinal applications thereof.
    Type: Application
    Filed: October 30, 2021
    Publication date: December 28, 2023
    Inventors: Gurulingappa Hallur, Naveena Madhyastha, Michael Rajesh Stephen, Bruce Roth, Anjali Pandey, Tracy Saxton
  • NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT
    Publication number: 20230346753
    Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes.
    Type: Application
    Filed: December 2, 2022
    Publication date: November 2, 2023
    Inventors: Kenneth W. Bair, Timm R. Baumeister, Alexandre J. Buckmelter, Karl H. Clodfelter, Peter Dragovich, Francis Gosselin, Bingsong Han, Jian Lin, Dominic J. Reynolds, Bruce Roth, Chase C. Smith, Zhongguo Wang, Po-Wai Yuen, Xiaozhang Zheng
  • FUSED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF
    Publication number: 20230027026
    Abstract: The present disclosure relates to a class of fused pyrimidine compounds of Formula I, their stereoisomers, tautomers, pharmaceutically acceptable salts, polymorphs, solvates, and hydrates thereof. The present disclosure also relates to a process of preparation of these fused pyrimidine compounds, and to pharmaceutical compositions containing them.
    Type: Application
    Filed: September 26, 2020
    Publication date: January 26, 2023
    Inventors: Chandregowda Venkateshappa, Dhanalakshmi Sivanandhan, Sridharan Rajagopal, Bruce Roth, Anjali Pandey, Tracy Saxton, Gurulingappa Hallur, Naveena Madhyastha, Naveen Sadhu M
  • Compounds and compositions for the inhibition of NAMPT
    Patent number: 11547701
    Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes.
    Type: Grant
    Filed: September 11, 2020
    Date of Patent: January 10, 2023
    Assignees: Valo Health, Inc., Genentech, Inc.
    Inventors: Kenneth W. Bair, Timm R. Baumeister, Alexandre J. Buckmelter, Karl H. Clodfelter, Peter Dragovich, Francis Gosselin, Bingsong Han, Jian Lin, Dominic J. Reynolds, Bruce Roth, Chase C. Smith, Zhongguo Wang, Po-Wai Yuen, Xiaozhang Zheng
  • NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT
    Publication number: 20210244717
    Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes.
    Type: Application
    Filed: September 11, 2020
    Publication date: August 12, 2021
    Inventors: Kenneth W. Bair, Timm R. Baumeister, Alexandre J. Buckmelter, Karl H. Clodfelter, Peter Dragovich, Francis Gosselin, Bingsong Han, Jian Lin, Dominic J. Reynolds, Bruce Roth, Chase C. Smith, Zhongguo Wang, Po-Wai Yuen, Xiaozhang Zheng
  • Compounds and compositions for the inhibition of NAMPT
    Patent number: 10772874
    Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes.
    Type: Grant
    Filed: August 12, 2019
    Date of Patent: September 15, 2020
    Inventors: Kenneth W. Bair, Timm R. Baumeister, Alexandre J. Buckmelter, Karl H. Clodfelter, Peter Dragovich, Francis Gosselin, Bingsong Han, Jian Lin, Dominic J. Reynolds, Bruce Roth, Chase C. Smith, Zhongguo Wang, Po-Wai Yuen, Xiaozhang Zheng
  • NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT
    Publication number: 20190388405
    Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes.
    Type: Application
    Filed: August 12, 2019
    Publication date: December 26, 2019
    Inventors: Kenneth W. Bair, Timm R. Baumeister, Alexandre J. Buckmelter, Karl H. Clodfelter, Peter Dragovich, Francis Gosselin, Bingsong Han, Jian Lin, Dominic J. Reynolds, Bruce Roth, Chase C. Smith, Zhongguo Wang, Po-Wai Yuen, Xiaozhang Zheng
  • Compounds and compositions for the inhibition of NAMPT
    Patent number: 10456382
    Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: October 29, 2019
    Assignees: FORMA TM, LLC, Genentech, Inc.
    Inventors: Kenneth W. Bair, Timm R. Baumeister, Alexandre J. Buckmelter, Karl H. Clodfelter, Peter Dragovich, Francis Gosselin, Bingsong Han, Jian Lin, Dominic J. Reynolds, Bruce Roth, Chase C. Smith, Zhongguo Wang, Po-Wai Yuen, Xiaozhang Zheng
  • Compounds and compositions for the inhibition of NAMPT
    Patent number: 10272072
    Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: April 30, 2019
    Assignees: Forma TM, LLC, Genentech, Inc.
    Inventors: Kenneth W. Bair, Timm R. Baumeister, Alexandre Joseph Buckmelter, Karl H. Clodfelter, Peter Dragovich, Francis Gosselin, Bingsong Han, Jian Lin, Dominic J. Reynolds, Bruce Roth, Chase C. Smith, Zhongguo Wang, Po-Wai Yuen, Xiaozhang Zheng
  • NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT
    Publication number: 20190105307
    Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes.
    Type: Application
    Filed: December 6, 2018
    Publication date: April 11, 2019
    Inventors: Kenneth W. Bair, Timm R. Baumeister, Alexandre J. Buckmelter, Karl H. Clodfelter, Peter Dragovich, Francis Gosselin, Bingsong Han, Jian Lin, Dominic J. Reynolds, Bruce Roth, Chase C. Smith, Zhongguo Wang, Po-Wai Yuen, Xiaozhang Zheng
  • NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT
    Publication number: 20170368039
    Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes.
    Type: Application
    Filed: November 15, 2016
    Publication date: December 28, 2017
    Applicants: Forma TM, LLC, Genentech, Inc.
    Inventors: BAIR W. Kenneth, Timm R. BAUMEISTER, Alexandre J. BUCKMELTER, Karl H. CLODFELTER, Peter DRAGOVICH, Francis GOSSELIN, Bingsong HAN, Jian LIN, Dominic J. REYNOLDS, Bruce ROTH, Chase C. SMITH, Zhongguo WANG, Po-Wai YUEN, Xiaozhang ZHENG
  • NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT
    Publication number: 20140294805
    Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes.
    Type: Application
    Filed: September 2, 2011
    Publication date: October 2, 2014
    Inventors: Kenneth W. Bair, Timm R. Baumeister, Alexandre J. Buckmelter, Karl H. Clodfelter, Peter Dragovich, Francis Gosselin, Bingsong Han, Jian Lin, Dominic J. Reynolds, Bruce Roth, Chase C. Smith, Zhongguo Wang, Po-Wai Yuen, Xiaozhang Zheng
  • METHOD OF TREATING CANCER
    Publication number: 20080045595
    Abstract: The present invention provides therapeutic compounds and methods for the treatment of refractory and multidrug resistant cancers in patients in need of such treatment.
    Type: Application
    Filed: June 27, 2007
    Publication date: February 21, 2008
    Applicant: Myriad Genetics, Incorporated
    Inventors: Bruce Roth, Vijay Baichwal, Chris Pleiman
  • Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor
    Publication number: 20050075348
    Abstract: Disclosed are novel compounds having the formula or a physiologically acceptable salt, amide, ester or prodrug thereof. The compounds can be used to modulate (antagonize, agonize) chemokine receptor function. Also disclosed is a method for treating a patient having an inflammatory disease and/or viral infection comprising administering an effective amount of a compound of Formula I. In particular embodiments, the invention is a method for treating a patient infected with HIV.
    Type: Application
    Filed: November 8, 2004
    Publication date: April 7, 2005
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Geraldine Harriman, Kenneth Carson, Daniel Flynn, Michael Solomon, Yuntao Song, Bharat Trivedi, Bruce Roth, Christine Kolz, Ly Pham, Kuai-lin Sun
  • Diphenylamino ketone derivatives as MEK inhibitors
    Publication number: 20050059710
    Abstract: The present invention relates to diphenylamino ketone derivatives, pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: July 22, 2004
    Publication date: March 17, 2005
    Inventors: Stephen Barrett, Michael Kaufman, Mark Plummer, Jessica Reed, Bruce Roth, Kevin Schlosser
  • Novel pyrrole-based HMG-CoA reductase inhibitors
    Publication number: 20050043364
    Abstract: 50 HMGCo-A reductase inhibitor compounds useful as hypocholesterolemic and hypolipidemic compounds are provided. Also provided are pharmaceutical compositions of the compounds. Methods of making and methods of using the compounds are also provided.
    Type: Application
    Filed: June 7, 2004
    Publication date: February 24, 2005
    Inventors: Robert Kennedy, William Park, Bruce Roth, Yuntao Song, Bharat Trivedi
  • Automotive instrumentation receiver
    Patent number: D512368
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: December 6, 2005
    Inventor: Bruce A. Roth
  • Motorcycle gauge pod
    Patent number: D525926
    Type: Grant
    Filed: February 18, 2005
    Date of Patent: August 1, 2006
    Inventor: Bruce A. Roth
  • [R-(R*R*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid, its lactone form and salts thereof
    Patent number: RE40667
    Abstract: [R-(R*,R*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-((1-methylethyl)-3-phenyl-4-[(phenylamino)-carbonyl)]-1H-pyrrole-1-heptanoic acid or (2R-trans)-5-(4-fluoro-phenyl)-2-(1-methylethyl-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide; and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: January 16, 2007
    Date of Patent: March 17, 2009
    Assignee: Warner-Lambert Company LLC
    Inventor: Bruce Roth