Patents by Inventor Bruce Sargent

Bruce Sargent has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Capped pyrazinoylguanidine sodium channel blockers
    Patent number: 8507497
    Abstract: Provided is a method of treating cystic fibrosis in which an effective amount of a compound represented by formula (I) is administered to a subject in need thereof: where the structural variables are as defined herein.
    Type: Grant
    Filed: May 9, 2012
    Date of Patent: August 13, 2013
    Assignee: Parion Sciences, Inc.
    Inventors: Michael R. Johnson, Bruce F. Molino, Bruce Sargent, Jianzhong Zhang
  • Capped pyrazinoylguanidine sodium channel blockers
    Patent number: 8431579
    Abstract: Provided are compounds represented by the formula: where the structural variables are as defined herein. The compounds function as sodium channel blockers and my be used for promoting hydration of mucosal surfaces.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: April 30, 2013
    Assignee: Parion Sciences, Inc.
    Inventors: Michael R. Johnson, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • NEW CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
    Publication number: 20120220606
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: May 9, 2012
    Publication date: August 30, 2012
    Applicant: PARION SCIENCES, INC.
    Inventors: Michael R. JOHNSON, Bruce F. Molino, Bruce Sargent, Jianzhong Zhang
  • Capped pyrazinoylguanidine sodium channel blockers
    Patent number: 8211895
    Abstract: The present application relates to pyrazinoyl guanidine sodium channel blockers having the structure: or a pharmaceutically acceptable salt thereof, where the structural variables are as defined herein. The present invention also relates pharmaceutical compositions comprising the sodium channel blockers and their use in methods of treatment, including the treatment of cardiovascular disease, cystic fibrosis, and chronic bronchitis and in the rehydration of mucosal surfaces and promotion of mucus clearance in a patient.
    Type: Grant
    Filed: September 7, 2010
    Date of Patent: July 3, 2012
    Assignee: Parion Sciences, Inc.
    Inventors: Michael R. Johnson, Bruce F. Molino, Bruce Sargent, Jianzhong Zhang
  • CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
    Publication number: 20110046158
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: November 4, 2010
    Publication date: February 24, 2011
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael R. JOHNSON, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • Capped pyrazinoylguanidine sodium channel blockers
    Patent number: 7868010
    Abstract: The invention relates to substituted pyrazinoylguanidine compounds. These compounds are useful as sodium channel blockers, and may be effective in treating a variety of conditions including chronic bronchitis and cystic fibrosis.
    Type: Grant
    Filed: March 17, 2008
    Date of Patent: January 11, 2011
    Assignee: Parion Sciences, Inc.
    Inventors: Michael R. Johnson, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • NEW CAPPED Pyrazinoylguanidine SODIUM CHANNEL BLOCKERS
    Publication number: 20110003832
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: September 7, 2010
    Publication date: January 6, 2011
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael R. JOHNSON, Bruce F. Molino, Bruce Sargent, Jianzhong Zhang
  • Capped pyrazinoylguanidine sodium channel blockers
    Patent number: 7807834
    Abstract: The present invention relates to group of pyrazinoylguanidine compounds useful as sodium channel blockers. The compounds may be used to promote promoting hydration of mucosal surfaces.
    Type: Grant
    Filed: August 3, 2005
    Date of Patent: October 5, 2010
    Assignee: Parion Sciences, Inc.
    Inventors: Michael R. Johnson, Bruce F. Molino, Bruce Sargent, Jianzhong Zhang
  • CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
    Publication number: 20090018144
    Abstract: The present invention relates to compounds represented by formula (I): where the structural variables are as defined herein. The compounds are useful for promoting hydration of mucosal surfaces.
    Type: Application
    Filed: July 11, 2008
    Publication date: January 15, 2009
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael R. Johnson, Bruce Molino, Jianzhong Zhang, Bruce Sargent
  • Capped pyrazinoylguanidine sodium channel blockers
    Patent number: 7410968
    Abstract: The present invention relates to compounds represented by formula (I): where the structural variables are as defined herein. The compounds are useful for promoting hydration of mucosal surfaces.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: August 12, 2008
    Assignee: PARION SCIENCES, Inc.
    Inventors: Michael R. Johnson, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
    Publication number: 20080176863
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: March 17, 2008
    Publication date: July 24, 2008
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael R. JOHNSON, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
    Publication number: 20080171880
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: March 17, 2008
    Publication date: July 17, 2008
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael R. JOHNSON, Bruce Molino, Jianzhong Zhang, Bruce Sargent
  • CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
    Publication number: 20080167466
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: March 17, 2008
    Publication date: July 10, 2008
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael R. JOHNSON, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • Capped pyrazinoylguanidine sodium channel blockers
    Patent number: 7388013
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Grant
    Filed: May 27, 2005
    Date of Patent: June 17, 2008
    Assignee: Parion Sciences, Inc.
    Inventors: Michael R. Johnson, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • Capped pyrazinoylguanidine sodium channel blockers
    Patent number: 7368447
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: May 6, 2008
    Assignee: Parion Sciences, Inc.
    Inventors: Michael R. Johnson, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • Capped pyrazinoylguanidine sodium channel blockers
    Patent number: 7368451
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: May 6, 2008
    Assignee: Parion Sciences, Inc.
    Inventors: Michael R. Johnson, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • Capped pyrazinoylguanidine sodium channel blockers
    Patent number: 7247637
    Abstract: The present invention relates to a compound represented by formula (I): where the structural variables are as defined herein. The compound is useful for promoting hydration of mucosal surfaces.
    Type: Grant
    Filed: May 18, 2005
    Date of Patent: July 24, 2007
    Assignee: Parion Sciences, Inc.
    Inventors: Michael R. Johnson, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • New capped pyrazinoylguanidine sodium channel blockers
    Publication number: 20070032509
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: August 3, 2005
    Publication date: February 8, 2007
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael Johnson, Bruce Molino, Bruce Sargent, Jianzhong Zhang
  • Capped pyrazinoylguanidine sodium channel blockers
    Publication number: 20060205738
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: August 26, 2005
    Publication date: September 14, 2006
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael Johnson, Bruce Molino, Jianzhong Zhang, Bruce Sargent
  • Capped pyrazinoylguanidine sodium channel blockers
    Patent number: 7064129
    Abstract: Compounds are provided which are represented by the formula: where the structural variables are defined herein. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Grant
    Filed: August 18, 2004
    Date of Patent: June 20, 2006
    Assignee: Parion Sciences, Inc.
    Inventors: Michael R. Johnson, Bruce Molino, Jianzhong Zhang, Bruce Sargent