Patents by Inventor Bruce Scott Bochner

Bruce Scott Bochner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NANOCARRIERS FOR TARGETED DELIVERY OF THERAPEUTICS
    Publication number: 20240350654
    Abstract: Provided herein are therapeutic PPSU nanoparticles for targeting specific cell types and delivering therapeutic compounds. Therapeutic PPSU nanoparticles include nanoparticles comprising midostaurin and anti-siglec antibodies for targeting mast cells. Also provided herein are methods for preparing the therapeutic PPU nanoparticles and using them to treat malignant mast cell disorders.
    Type: Application
    Filed: April 18, 2024
    Publication date: October 24, 2024
    Inventors: Clayton Hunter Rische, Bruce Scott Bochner, Evan Alexander Scott
  • SURFACE COATING PPSU NANOPARTICLES FOR THERAPEUTIC MODULATION OF MAST CELLS
    Publication number: 20240091164
    Abstract: The present disclosure provides methods of adsorbing proteins to the surface of a nanoparticle. Particularly, methods for adsorbing anti-Siglec-6 and anti-Fc?RI antibodies to PPSU nanoparticles, are described. The disclosure further provides compositions comprising the nanoparticles are methods of their use to prevent mast cell secretion and anaphylaxis.
    Type: Application
    Filed: September 8, 2023
    Publication date: March 21, 2024
    Inventors: Evan Alexander Scott, Bruce Scott Bochner, Clayton Hunter Rische
  • Detection of Auto-Antibodies to Specific Glycans as Diagnostic Tests for Autoimmune Diseases
    Publication number: 20140287951
    Abstract: The invention provides uses, methods, and kits for diagnosing an autoimmune disease, particularly scleroderma and systemic lupus erythematosus, in a subject by detecting the presence of one or more antibodies that specifically bind to one or more glycans in a subject sample.
    Type: Application
    Filed: March 17, 2014
    Publication date: September 25, 2014
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Bruce Scott Bochner, Stephan Matthias von Gunten, Antony Rosen, Thomas Grader-Beck
  • Detection of Auto-Antibodies to Specific Glycans as Diagnostic Tests for Autoimmune Diseases
    Publication number: 20120190581
    Abstract: The invention provides uses, methods, and kits for diagnosing an autoimmune disease, particularly scleroderma and systemic lupus erythematosus, in a subject by detecting the presence of one or more antibodies that specifically bind to one or more glycans in a subject sample.
    Type: Application
    Filed: August 25, 2010
    Publication date: July 26, 2012
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Bruce Scott Bochner, Stephan Matthias Von Gunten, Antony Rosen, Thomas Grader-Beck
  • Methods of use of sialoadhesin factor-2 antibodies
    Patent number: 8197811
    Abstract: Monoclonal antibodies have been generated that bind to human sialoadhesion factor-2. These antibodies are useful as diagnostic and therapeutic reagents.
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: June 12, 2012
    Assignee: The Johns Hopkins University
    Inventors: Julie A. Abrahamson, Connie L. Erickson-Miller, Kristine Kay Kikly, Bruce Scott Bochner, Robert Schleimer, T. Esra Nutku
  • Methods and compositions for treating diseases and disorders associated with siglec-8.
    Patent number: 8178512
    Abstract: The invention provides therapeutic methods and compositions for the prevention and treatment of Siglec-8 associated diseases and disorders such as asthma and allergic reactions. In particular, the invention provides methods and compositions for the prevention and treatment of diseases and disorders associated with Siglec-8 expressing cells in humans, as well as other animals, through the administration of one or more novel, carbohydrate-based compounds.
    Type: Grant
    Filed: June 28, 2010
    Date of Patent: May 15, 2012
    Assignee: Johns Hopkins University
    Inventors: Bruce Scott Bochner, Ronald L. Schnaar
  • METHODS AND COMPOSITIONS FOR TREATING DISEASES AND DISORDERS ASSOCIATED WITH SIGLEC-8
    Publication number: 20110046078
    Abstract: The invention provides therapeutic methods and compositions for the prevention and treatment of Siglec-8 associated diseases and disorders such as asthma and allergic reactions. In particular, the invention provides methods and compositions for the prevention and treatment of diseases and disorders associated with Siglec-8 expressing cells in humans, as well as other animals, through the administration of one or more novel, carbohydrate-based compounds.
    Type: Application
    Filed: June 28, 2010
    Publication date: February 24, 2011
    Inventors: Bruce Scott Bochner, Ronald L. Schnaar