Patents by Inventor Bruce Shiramizu

Bruce Shiramizu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnosis and treatment of cancer having clonal macrophage involvement
    Patent number: 6537523
    Abstract: The presence of clonal macrophages in pre-cancerous and cancerous tissue represents an early stage of the disease in which clonal expansion of macrophages occurs due to HIV integration or other genetic mutation. Clonally expanded macrophages induce proliferation of surrounding tissue leading to cancerous tumor growth. The invention provides methods and kits for diagnosis of HIV- and non-HIV-associated clonal expansion of macrophages in pre-cancerous and cancerous tissue. The invention also provides methods for the treatment of cancers induced by clonal macrophage expansion and proliferation of surrounding tissue.
    Type: Grant
    Filed: November 20, 1997
    Date of Patent: March 25, 2003
    Assignee: The Regents of the University of California
    Inventors: Michael S. McGrath, Brian Herndier, Bruce Shiramizu
  • Diagnosis and treatment of cancer having clonal macrophage involvement
    Patent number: 5744122
    Abstract: The presence of clonal macrophages in pre-cancerous and cancerous tissue represents an early stage of the disease in which clonal expansion of macrophages occurs due to HIV integration or other genetic mutation. Clonally expanded macrophages induce proliferation of surrounding tissue leading to cancerous tumor growth. The invention provides methods and kits for diagnosis of HIV- and non-HIV-associated clonal expansion of macrophages in pre-cancerous and cancerous tissue. The invention also provides methods for the treatment of cancers induced by clonal macrophage expansion and proliferation of surrounding tissue.
    Type: Grant
    Filed: February 15, 1996
    Date of Patent: April 28, 1998
    Assignee: University of California, San Franciso
    Inventors: Michael S. McGrath, Brian Herndier, Bruce Shiramizu
  • Diagnosis and treatment of cell proliferative disease having clonal macrophage involvement
    Patent number: 5639600
    Abstract: The presence of clonal macrophages in pre-cancerous and cancerous tissue represents an early stage of the disease in which clonal expansion of macrophages occurs due to HIV integration or other genetic mutation. Clonally expanded macrophages induce proliferation of surrounding tissue leading to cancerous tumor growth. The invention provides methods and kits for diagnosis of HIV- and non-HIV-associated clonal expansion of macrophages in pre-cancerous and cancerous tissue and other cell proliferative diseased tissue. The invention also provides methods for the treatment of cell proliferative diseases induced by clonal macrophage expansion and proliferation of surrounding tissue.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 17, 1997
    Assignee: The Regents of the University of California
    Inventors: Michael S. McGrath, Brian Herndier, Bruce Shiramizu
  • Sensitive method for localizing chromosomal breakpoints
    Patent number: 5582973
    Abstract: A sensitive method for identifying chromosomal breakpoints flanked by repeat sequences, through amplification by polymerase chain reaction, is described. The application of the method to the detection of Burkitt's lymphoma cells is demonstrated.
    Type: Grant
    Filed: December 2, 1993
    Date of Patent: December 10, 1996
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Ian T. Magrath, Bruce Shiramizu
  • Diagnosis of cancer having clonal macrophage involvement
    Patent number: 5580715
    Abstract: The presence of clonal macrophages in pre-cancerous and cancerous tissue represents an early stage of the disease in which clonal expansion of macrophages occurs due to HIV integration or other genetic mutation. Clonally expanded macrophages induce proliferation of surrounding tissue leading to cancerous tumor growth. The invention provides methods and kits for diagnosis of HIV- and non-HIV-associated clonal expansion of macrophages in pre-cancerous and cancerous tissue. The invention also provides methods for the treatment of cancers induced by clonal macrophage expansion and proliferation of surrounding tissue.
    Type: Grant
    Filed: August 5, 1994
    Date of Patent: December 3, 1996
    Assignee: The Regents of the University of California
    Inventors: Michael S. McGrath, Brian Herndier, Bruce Shiramizu