Patents by Inventor Bruce Stanton

Bruce Stanton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulators of the ABC transporter family and methods for their use
    Patent number: 8153597
    Abstract: An isolated factor derived from the bacterium Pseudomonas aeruginosa and confirmed by proteomics to be a protein that reduces expression of ABC transmembrane proteins and active fragments and mimetics thereof are provided. Also provided is a method for inhibiting expression of ABC transmembrane proteins in cells by administering to the cells the isolated factor or protein or active fragment thereof or a mimetic thereof. Such methods are useful in the enhancing delivery of small molecule therapeutic agents to the CNS and in treating cancers, particularly multidrug resistant cancers, and secretory diarrhea. In addition, compositions, methods for identifying compositions and methods for use of compositions that inhibit suppression of ABC transmembrane protein expression or reduce epoxide hydrolase activity by this factor are provided. Such compositions and methods are useful in treatment of cystic fibrosis.
    Type: Grant
    Filed: February 25, 2010
    Date of Patent: April 10, 2012
    Assignee: Trustees of Dartmouth College
    Inventors: Bruce Stanton, George O'Toole, Jr., Agnieszka Swiateck-Urban, Daniel P. MacEachran, Sophie Moreau Marquis
  • Methods for modulating ATP-binding cassette transmembrane reporter protein expression
    Patent number: 7585639
    Abstract: Methods and compositions for modulating cell surface protein expression are provided. The compositions of the present invention are gene constructs comprising ATP-binding cassette transmembrane reporter proteins.
    Type: Grant
    Filed: October 4, 2000
    Date of Patent: September 8, 2009
    Assignee: Trustees of Dartmouth College
    Inventors: Joshua Hamilton, Bruce Stanton
  • Modulators of the ABC Transporter Family and Methods for Their Use
    Publication number: 20070275894
    Abstract: An isolated factor derived from the bacterium Pseudomonas aeruginosa and confirmed by proteomics to be a protein that reduces expression of ABC transmembrane proteins and active fragments and mimetics thereof are provided. Also provided is a method for inhibiting expression of ABC transmembrane proteins in cells by administering to the cells the isolated factor or protein or active fragment thereof or a mimetic thereof. Such methods are useful in the enhancing delivery of small molecule therapeutic agents to the CNS and in treating cancers, particularly multidrug resistant cancers, and secretory diarrhea. In addition, compositions, methods for identifying compositions and methods for use of compositions that inhibit suppression of ABC transmembrane protein expression or reduce epoxide hydrolase activity by this factor are provided. Such compositions and methods are useful in treatment of cystic fibrosis.
    Type: Application
    Filed: March 27, 2007
    Publication date: November 29, 2007
    Inventors: Bruce Stanton, George O'Toole, Agnieszka Swiateck-Urban, Daniel P. MacEachran, Sophie Moreau Marquis