Patents by Inventor Bruce Steven Klein

Bruce Steven Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide MHCII tetramers to detect endogenous calnexin specific CD4 T cells
    Patent number: 11789019
    Abstract: The present application discloses proteins or peptides and methods of using such proteins or peptides to evaluate the immune status of a patient. In one embodiment, proteins or peptides may be used to detect endogenous calnexin specific CD4 T cells. In one preferred embodiment, the proteins or peptides may comprise peptide-MHCII tetramers (pMHC tetramers).
    Type: Grant
    Filed: August 1, 2019
    Date of Patent: October 17, 2023
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Bruce Steven Klein, Marcel Wuethrich
  • Vaccine Adjuvant
    Publication number: 20210205445
    Abstract: A Dectin-2 ligand vaccine adjuvant and a method of making and using the Dectin-2 ligand vaccine adjuvant in a vaccine to immunize a patient are disclosed. Also discloses is a vaccine composition comprising a Bl-Eng2 antigen and methods of using the vaccine composition to immunize a subject against a fungal infection.
    Type: Application
    Filed: February 26, 2021
    Publication date: July 8, 2021
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Bruce Steven Klein, Huafeng Wang, Marcel Wuethrich, Tristan Theodore Brandhorst
  • Method of treating fungal infection
    Patent number: 10806776
    Abstract: A vaccine comprising Calnexin fragment and a method of using the vaccine to immunize a patient against fungi are disclosed. The Calnexin fragment may be either a full-length native version or a functionally equivalent version of full-length Calnexin.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: October 20, 2020
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Bruce Steven Klein, Theodore Tristan Brandhorst, Thomas Sullivan, Marcel Wuethrich
  • Peptide MHCII Tetramers to Detect Endogenous Calnexin Specific CD4 T Cells
    Publication number: 20190361022
    Abstract: The present application discloses proteins or peptides and methods of using such proteins or peptides to evaluate the immune status of a patient. In one embodiment, proteins or peptides may be used to detect endogenous calnexin specific CD4 T cells. In one preferred embodiment, the proteins or peptides may comprise peptide-MHCII tetramers (pMHC tetramers).
    Type: Application
    Filed: August 1, 2019
    Publication date: November 28, 2019
    Inventors: Bruce Steven Klein, Marcel Wuethrich
  • Peptide MHCII tetramers to detect endogenous calnexin specific CD4 T cells
    Patent number: 10416158
    Abstract: The present application discloses proteins or peptides and methods of using such proteins or peptides to evaluate the immune status of a patient. In one embodiment, proteins or peptides may be used to detect endogenous calnexin specific CD4 T cells. In one preferred embodiment, the proteins or peptides may comprise peptide-MHCII tetramers (pMHC tetramers).
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: September 17, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Bruce Steven Klein, Marcel Wuethrich
  • METHOD OF TREATING FUNGAL INFECTION
    Publication number: 20190000942
    Abstract: A vaccine comprising Calnexin fragment and a method of using the vaccine to immunize a patient against fungi are disclosed. The Calnexin fragment may be either a full-length native version or a functionally equivalent version of full-length Calnexin.
    Type: Application
    Filed: May 2, 2018
    Publication date: January 3, 2019
    Inventors: Bruce Steven Klein, Theodore Tristan Brandhorst, Thomas Sullivan, Marcel Wuethrich
  • Method of treating fungal infection
    Patent number: 9993534
    Abstract: A vaccine comprising Calnexin fragment and a method of using the vaccine to immunize a patient against fungi are disclosed. The Calnexin fragment may be either a full-length native version or a functionally equivalent version of full-length Calnexin.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: June 12, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Bruce Steven Klein, Theodore Tristan Brandhorst, Thomas Sullivan, Marcel Wuethrich
  • Vaccine Adjuvant
    Publication number: 20180110853
    Abstract: A Dectin-2 ligand vaccine adjuvant and a method of making and using the Dectin-2 ligand vaccine adjuvant in a vaccine to immunize a patient are disclosed. Also discloses is a vaccine composition comprising a Bl-Eng2 antigen and methods of using the vaccine composition to immunize a subject against a fungal infection.
    Type: Application
    Filed: October 18, 2017
    Publication date: April 26, 2018
    Inventors: Bruce Steven Klein, Huafeng Wang, Marcel Wuethrich, Tristan Theodore Brandhorst
  • Antifungal treatment
    Patent number: 9896442
    Abstract: A method of treating or preventing fungal infection, which includes identifying a plant or animal having a fungal infection and administering an effective amount of an anti-fungal composition to the plant or animal to reduce the fungal infection. In a preferred form of the present invention, the antifungal composition is compound 13 or 33 and is combined with an azole compound, such as fluconazole.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: February 20, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Bruce Steven Klein, Brad Mark Tebbets
  • Antifungal Treatment
    Publication number: 20160289224
    Abstract: A method of treating or preventing fungal infection, which includes identifying a plant or animal having a fungal infection and administering an effective amount of an anti-fungal composition to the plant or animal to reduce the fungal infection. In a preferred form of the present invention, the antifungal composition is compound 13 or 33 and is combined with an azole compound, such as fluconazole.
    Type: Application
    Filed: April 1, 2016
    Publication date: October 6, 2016
    Inventors: Bruce Steven Klein, Brad Mark Tebbets
  • Peptide MHCII Tetramers to Detect Endogenous Calnexin Specific CD4 T Cells
    Publication number: 20150301044
    Abstract: The present application discloses proteins or peptides and methods of using such proteins or peptides to evaluate the immune status of a patient. In one embodiment, proteins or peptides may be used to detect endogenous calnexin specific CD4 T cells. In one preferred embodiment, the proteins or peptides may comprise peptide-MHCII tetramers (pMHC tetramers).
    Type: Application
    Filed: March 10, 2015
    Publication date: October 22, 2015
    Inventors: Bruce Steven Klein, Marcel Wuethrich
  • Method of Treating Fungal Infection
    Publication number: 20140271720
    Abstract: A vaccine comprising Calnexin fragment and a method of using the vaccine to immunize a patient against fungi are disclosed. The Calnexin fragment may be either a full-length native version or a functionally equivalent version of full-length Calnexin.
    Type: Application
    Filed: March 11, 2014
    Publication date: September 18, 2014
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Bruce Steven Klein, Theodore Tristan Brandhorst, Thomas Sullivan, Marcel Wuethrich
  • Antifungal Treatment
    Publication number: 20140094494
    Abstract: A method of treating or preventing fungal infection, which includes identifying a plant or animal having a fungal infection and administering an effective amount of an anti-fungal composition to the plant or animal to reduce the fungal infection. In a preferred form of the present invention, the antifungal composition is compound 13 or 33 and is combined with an azole compound, such as fluconazole.
    Type: Application
    Filed: September 17, 2013
    Publication date: April 3, 2014
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Bruce Steven Klein, Brad Mark Tebbets
  • Antifungal Treatment
    Publication number: 20110319455
    Abstract: A method of treating or preventing fungal infection, which includes identifying a plant or animal having a fungal infection and administering an effective amount of an anti-fungal composition to the plant or animal to reduce the fungal infection. In a preferred form of the present invention, the antifungal composition is compound 13 or 33 and is combined with an azole compound, such as fluconazole.
    Type: Application
    Filed: April 19, 2011
    Publication date: December 29, 2011
    Inventors: Bruce Steven Klein, Brad Mark Tebbets