Patents by Inventor Bruce Stillman

Bruce Stillman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IDENTIFICATION OF RNAI TARGETS AND USE OF RNAI FOR RATIONAL THERAPY OF CHEMOTHERAPY-RESISTANT LEUKEMIA AND OTHER CANCERS
    Publication number: 20150283101
    Abstract: Provided is a mosaic mouse model for use in determining the potency of an shRNA in vivo for reducing survival of cancer cells of chemotherapy-resistant leukemia. The syngeneic mouse recipient is transplanted with tet-on competent leukemia cells carrying a bicistronic nucleic acid construct comprising a promoter operably linked to a fusion gene associated with chemotherapy-resistant leukemia, and a sequence encoding a reverse tet-transactivator protein, such that both coding sequences are co-expressed from the promoter. Also provided are methods of treating soft tissue cancers.
    Type: Application
    Filed: November 3, 2014
    Publication date: October 8, 2015
    Inventors: Bruce STILLMAN, Scott W. LOWE, Anthony MAZUREK, Johannes Ekkehart ZUBER, Christopher VAKOC, Katherine MCJUNKIN
  • Identification of RNAI targets and use of RNAI for rational therapy of chemotherapy-resistant leukemia and other cancers
    Patent number: 8895526
    Abstract: Provided is a mosaic mouse model for use in determining the potency of an shRNA in vivo for reducing survival of cancer cells of chemotherapy-resistant leukemia. The syngeneic mouse recipient is transplanted with tet-on competent leukemia cells carrying a bicistronic nucleic acid construct comprising a promoter operably linked to a fusion gene associated with chemotherapy-resistant leukemia, and a sequence encoding a reverse tet-transactivator protein, such that both coding sequences are co-expressed from the promoter. Also provided are methods of treating soft tissue cancers.
    Type: Grant
    Filed: March 29, 2010
    Date of Patent: November 25, 2014
    Assignee: Cold Spring Harbor Laboratory
    Inventors: Bruce Stillman, Scott W. Lowe, Anthony Mazurek, Johannes Ekkehart Zuber, Christopher Vakoc, Katherine McJunkin
  • IDENTIFICATION OF RNAI TARGETS AND USE OF RNAI FOR RATIONAL THERAPY OF CHEMOTHERAPY-RESISTANT LEUKEMIA AND OTHER CANCERS
    Publication number: 20120272346
    Abstract: Provided is a mosaic mouse model for use in determining the potency of an shRNA in vivo for reducing survival of cancer cells of chemotherapy-resistant leukemia. The syngeneic mouse recipient is transplanted with tet-on competent leukemia cells carrying a bicistronic nucleic acid construct comprising a promoter operably linked to a fusion gene associated with chemotherapy-resistant leukemia, and a sequence encoding a reverse tet-transactivator protein, such that both coding sequences are co-expressed from the promoter. Also provided are methods of treating soft tissue cancers.
    Type: Application
    Filed: March 29, 2010
    Publication date: October 25, 2012
    Inventors: Bruce Stillman, Scott W. Lowe, Anthony Mazurek, Johannes Ekkehart Zuber, Christopher Vakoc, Katherine McJunkin
  • Methods of immunoassay for human CDC6
    Patent number: 6361954
    Abstract: The invention pertains to novel genes which function in the regulation of DNA replication and/or entry of a cell into mitosis. Tile invention also pertains to novel proteins encoded by the genes described herein, antibodies which bind the encoded protein, and homologs of the novel genes which function in regulation of DNA replication and/or entry of a cell into mitosis find hybridize to the DNA sequence of the novel genes. The invention also includes methods for determining the presence of a proliferative disorder comprising determining the presence of level of hscdc6.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: March 26, 2002
    Assignees: Cold Spring Harbor Laboratory, The University of Texas System
    Inventors: Bruce Stillman, R. Sanders Williams, Juan R. Mendez
  • DNA replication-regulating genes
    Patent number: 6074819
    Abstract: The invention pertains to novel genes which function in the regulation of DNA replication and/or entry of a cell into mitosis. The invention also pertains to novel proteins encoded by the genes described herein, antibodies which bind the encoded protein, and homologs of the novel genes which function in regulation of DNA replication and/or entry of a cell into mitosis and hybridize to the DNA sequence of the novel genes.
    Type: Grant
    Filed: May 15, 1996
    Date of Patent: June 13, 2000
    Assignees: Cold Spring Harbor Laboratory, Board of Regents, The University of Texas Systems
    Inventors: Bruce Stillman, R. Sanders Williams
  • DNA Replication-regulating genes
    Patent number: 5851821
    Abstract: The invention pertains to novel genes which function in the regulation of DNA replication and/or entry of a cell into mitosis. The invention also pertains to novel proteins encoded by the genes described herein, antibodies which bind the encoded protein, and homologs of the novel genes which function in regulation of DNA replication and/or entry of a cell into mitosis and hybridize to the DNA sequence of the novel genes.
    Type: Grant
    Filed: May 2, 1996
    Date of Patent: December 22, 1998
    Assignees: Cold Spring Harbor Laboratory, The Board of Regents, The University of Texas System
    Inventors: R. Sanders Williams, Bruce Stillman