Patents by Inventor Bruce T. Liang

Bruce T. Liang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR INHIBITION OF NEUTROPHIL RECRUITMENT IN MYCOCARDIAL ISCHEMIA-REPERFUSION INJURY
    Publication number: 20240041838
    Abstract: Compositions and methods for the treatment of a human subject in need of treatment for a neutrophil-related condition, in particular who has had a stroke or myocardial ischemia reperfusion injury, by administering to the subject a pharmaceutical composition including a compound of Formula 1, wherein the substituents are as described herein, and in particular wherein the compound is 4,4-dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one.
    Type: Application
    Filed: July 31, 2023
    Publication date: February 8, 2024
    Inventors: Zhichao Fan, Bruce T. Liang
  • Methods for the detection and monitoring of acute myocardial infarction
    Patent number: 8841084
    Abstract: Disclosed herein are methods of detecting and/or prognosing myocardial infarction by detecting a proteolytic fragment of caspase-3 such as the p17 fragment or the p12 fragment. The myocardial infarction can be STEMI or NSTEMI.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: September 23, 2014
    Assignees: The University of Connecticut, Mayo Foundation for Medical Education and Research
    Inventors: Bruce T. Liang, Heiko Schmitt, Michael Azrin, Christopher C. Pickett, Allan S. Jaffe
  • METHODS FOR THE DETECTION AND MONITORING OF ACUTE MYOCARDIAL INFARCTION
    Publication number: 20130143232
    Abstract: Disclosed herein are methods of detecting and/or prognosing myocardial infarction by detecting a proteolytic fragment of caspase-3 such as the p17 fragment or the p12 fragment. The myocardial infarction can be STEMI or NSTEMI.
    Type: Application
    Filed: May 12, 2011
    Publication date: June 6, 2013
    Applicants: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH, UNIVERSITY OF CONNECTICUT
    Inventors: Bruce T. Liang, Heiko Schmitt, Michael Azrin, Christopher C. Pickett, Allan S. Jaffe
  • Methods of treating heart failure with modified ATP, ADP and AMP compounds
    Patent number: 7348315
    Abstract: Disclosed herein are methods of using an adenosine analog or derivative for treating heart failure, increasing cardiac muscle contractility, increasing cardiac diastolic relaxation, and increasing vasodilation.
    Type: Grant
    Filed: March 25, 2003
    Date of Patent: March 25, 2008
    Assignee: The University of Connecticut
    Inventors: Bruce T Liang, Kenneth A Jacobson
  • Methods of treating heart failure with modified ATP, ADP and AMP compounds
    Publication number: 20030186929
    Abstract: Methods are provided for treating heart failure, increasing cardiac muscle contractility, increasing cardiac diastolic relaxation, and increasing vasodilation employing AMP, ADP, and ATP analogues.
    Type: Application
    Filed: March 25, 2003
    Publication date: October 2, 2003
    Inventors: Bruce T. Liang, Kenneth A. Jacobson
  • Methods and compositions for reducing ischemic injury of the heart by administering adenosine receptor agonists and antagonists
    Patent number: 6586413
    Abstract: Compositions and methods for reducing or preventing ischemic damage of the heart are disclosed. A preferred embodiment of the invention comprises the simultaneous administration of specific A3/A1 receptor agonists, to patients suffering from ischemic damage or at risk for the same. In yet another embodiment of the invention, a binary conjugate which acts as an agonist for the A3 receptor and an antagonist at the A2a receptor, is administered to reduce or prevent ischemic damage to the heart.
    Type: Grant
    Filed: March 5, 2001
    Date of Patent: July 1, 2003
    Assignees: The United States of America as represented by the Department of Health and Human Services, The Trustees of the University of Pennsylvania
    Inventors: Bruce T. Liang, Kenneth A. Jacobson
  • Methods and compositions for reducing ischemic injury of the heart by administering adenosine receptor agonists and antagonists
    Publication number: 20030092668
    Abstract: Compositions and methods for reducing or preventing ischemic damage of the heart are disclosed. A preferred embodiment of the invention comprises the simultaneous administration of specific A3/A1 receptor agonists, to patients suffering from ischemic damage or at risk for the same. In yet another embodiment of the invention, a binary conjugate which acts as an agonist for the A3 receptor and an antagonist at the A2a receptor, is administered to reduce or prevent ischemic damage to the heart.
    Type: Application
    Filed: March 5, 2001
    Publication date: May 15, 2003
    Inventors: Bruce T. Liang, Kenneth A. Jacobson
  • Methods for reducing ischemic injury of the heart via the sequential administration of monophosphoryl lipid A and adenosine receptor agents
    Patent number: 6329349
    Abstract: Materials and methods for reducing or preventing ischemic damage of the heart are disclosed. A preferred embodiment of the invention comprises methods of sequential administration of a plurality of cardioprotective agents to patients suffering from ischernic damage or at risk for the same.
    Type: Grant
    Filed: April 24, 2000
    Date of Patent: December 11, 2001
    Assignees: Trustees of the University of Pennsylvania, The United States of America as represented by the Department of Health and Human Services
    Inventors: Bruce T. Liang, Kenneth A. Jacobson
  • Purine nucleotide analogues, pharmaceutical compositions thereof, and methods of improving cardiac functions
    Patent number: 6255292
    Abstract: The specification discloses purine nucleotide analogues which modulate cardiac muscle contractility and possess vasodilator activity. In addition, related methods of administration and the identity of receptors that bind these compounds are disclosed.
    Type: Grant
    Filed: September 23, 1997
    Date of Patent: July 3, 2001
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Bruce T. Liang
  • Methods and compositions for reducing ischemic injury of the heart by administering adenosine receptor agonists and antagonists
    Patent number: 6211165
    Abstract: Compositions and methods for reducing or preventing ischemic damage of the heart are disclosed. A preferred embodiment of the invention comprises the simultaneous administration of specific A3/A1 receptor agonists, to patients suffering from ischemic damage or at risk for the same. In yet another embodiment of the invention, a binary conjugate which acts as an agonist for the A3 receptor and an antagonist at the A2a receptor, is administered to reduce or prevent ischemic damage to the heart.
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: April 3, 2001
    Assignees: The Trustees of the University of Pennsylvania, The United States of America as represented by the Department of Health and Human Services
    Inventors: Bruce T. Liang, Kenneth A. Jacobson
  • Methods for protecting against cardiac ischemia by administering adenosine A.sub.2a receptor antagonists
    Patent number: 5859019
    Abstract: Methods for reducing or preventing ischemic damage of the heart are disclosed. A preferred embodiment of the invention comprises the administration of a specific A.sub.2a receptor antagonist, 8-(3-chlorostyryl) caffeine, to patients suffering from ischemic damage or at risk for the same.
    Type: Grant
    Filed: March 7, 1997
    Date of Patent: January 12, 1999
    Assignees: Trustees of the University of Pennsylvania, National Institute of Health
    Inventors: Bruce T. Liang, Kenneth A. Jacobson
  • Inotropic ADP and ATP analogues and their pharmaceutical compositions
    Patent number: 5712258
    Abstract: Purine-containing compounds that modulate cardiac muscle contractility are provided, as well as methods for modulating cardiac muscle contractility and receptors that bind the compounds.
    Type: Grant
    Filed: March 23, 1995
    Date of Patent: January 27, 1998
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Bruce T. Liang