Patents by Inventor Bruce W. Penman

Bruce W. Penman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for detecting a receptor-ligand complex using a cytochrome P450 reporter gene
    Patent number: 5726041
    Abstract: An improved method for measuring the activity of a promoter sequence in a mammalian cell using a reporter gene is provided. The improvement involves using a reporter cassette containing a DNA sequence encoding a cytochrome P450 with a polyadenylation signal sequence as the reporter gene. Compositions containing the cytochrome P450 reporter cassette also are provided.
    Type: Grant
    Filed: August 22, 1996
    Date of Patent: March 10, 1998
    Assignees: Gentest Corporation, The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Charles L. Chrespi, Bruce W. Penman, Frank J. Gonzalez, Harry V. Gelboin, Talia Sher
  • Human cell line stably expressing 5cDNAS encoding procarcinogen-activating enzymes and related mutagenicity assays
    Patent number: 5429948
    Abstract: An immortal human cell line stably expressing a multiplicity of cytochrome P450s is provided. Preferably, the cell line is MCL-5, which stably expresses cytochrome P450 IA1, IA2, IIA3, IIIA4, and IIE1, as well as microsomal epoxide hydrolase. The cell line is useful in mutagenicity, toxicity and metabolism studies.
    Type: Grant
    Filed: December 28, 1992
    Date of Patent: July 4, 1995
    Assignee: Gentest Corporation
    Inventors: Charles L. Crespi, Bruce W. Penman, Robin L. Davies
  • Assay for mutagenesis in heterozygous diploid human lymphoblasts
    Patent number: 4302535
    Abstract: An assay is disclosed for determining mutagenic damage caused by the administration of a known or suspected mutagen to diploid human lymphoblastoid cell lines. The gene locus employed for this assay is the gene for thymidine kinase, uridine kinase, or cytidine deaminase. Since human lymphoblastoid cells contain two genes for these enzymes, heterozygotes of human lymphoblastoid cells are used in this assay.
    Type: Grant
    Filed: September 27, 1979
    Date of Patent: November 24, 1981
    Assignee: Massachusetts Institute of Technology
    Inventors: Thomas R. Skopek, Howard L. Liber, Bruce W. Penman, William G. Thilly, Henry Hoppe, IV