Patents by Inventor Bruce Wilcox

Bruce Wilcox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR DISTINGUISHING LUNG CANCER FROM NON-CANCER
    Publication number: 20260066051
    Abstract: Described herein are methods such as multi-omic methods for assessing a disease such as cancer. The multi-omic methods may integrate proteomic, transcriptomic, genomic, lipidomic, or metabolomic data. The method screening diseases or disease states. Also described herein are methods for screening for diseases or disease states from biological samples. The methods may include assessing whether a nodule, mass, or cyst is cancerous.
    Type: Application
    Filed: October 23, 2025
    Publication date: March 5, 2026
    Inventors: Philip MA, Bruce WILCOX, Francois COLLIN, Chinmay BELTHANGADY, Mi YANG, Manoj KHADKA, Manway LIU, John BLUME, Robert S. LANGER, JR., Ehdieh KHALEDIAN
  • METHODS FOR DISTINGUISHING LUNG CANCER FROM NON-CANCER
    Publication number: 20260066052
    Abstract: Described herein are methods such as multi-omic methods for assessing a disease such as cancer. The multi-omic methods may integrate proteomic, transcriptomic, genomic, lipidomic, or metabolomic data. The method screening diseases or disease states. Also described herein are methods for screening for diseases or disease states from biological samples. The methods may include assessing whether a nodule, mass, or cyst is cancerous.
    Type: Application
    Filed: October 23, 2025
    Publication date: March 5, 2026
    Inventors: Philip MA, Bruce WILCOX, Francois COLLIN, Chinmay BELTHANGADY, Mi YANG, Manoj KHADKA, Manway LIU, John BLUME, Robert S. LANGER, JR., Ehdieh KHALEDIAN
  • METHODS OF IDENTIFYING PANCREATIC CANCER
    Publication number: 20260031230
    Abstract: Described herein are methods for identifying a biological state such as pancreatic cancer in a subject. For example, a method may include obtaining protein data, transcriptomic data, genomic data, lipidomic data, or metabolomic data of a subject and identifying a likelihood of the subject having pancreatic cancer. The disclosure includes methods of making and using classifiers.
    Type: Application
    Filed: March 7, 2025
    Publication date: January 29, 2026
    Inventors: Philip MA, Bruce WILCOX, Chinmay BELTHANGADY, John BLUME, Manway LIU, Ehdieh KHALEDIAN, Preston B. WILLIAMS
  • MULTI-OMICS ASSESSMENT
    Publication number: 20250388973
    Abstract: Described herein are methods such as multi-omics methods for assessing a disease. The multi-omics methods may integrate proteomic, transcriptomic, genomic, lipidomic, or metabolomic data. The method screening diseases or disease states. Also described herein are methods for screening for diseases or disease states from biological samples. Also described herein are multi-omics databases and methods of using them.
    Type: Application
    Filed: January 28, 2025
    Publication date: December 25, 2025
    Inventors: Philip MA, Bruce WILCOX, Francois COLLIN, Chinmay BELTHANGADY, Mi YANG, Manoj KHADKA, Manway LIU, John BLUME, Ehdieh KHALEDIAN
  • Enhanced detection and quantitation of biomolecules
    Patent number: 12504432
    Abstract: Described herein are methods for screening for a disease state. The method may include obtaining multiple data sets and identifying the disease state based on a combination of the data sets. The data sets may include biomolecule measurements obtained by multiple methods, such as through the use of particles and reference biomolecules.
    Type: Grant
    Filed: April 23, 2024
    Date of Patent: December 23, 2025
    Assignee: PrognomiQ, Inc.
    Inventors: Bruce Wilcox, Kavya Swaminathan, Preston B. Williams, Jared Deyarmin, Mi Yang
  • GLYCOPROTEIN ASSESSMENT
    Publication number: 20250271435
    Abstract: Described herein are methods for screening or testing for a disease state using a biological sample. The method may include using glycoprotein, glycopeptide or glycan measurements in evaluating a biological state. The measurements may be obtained through the use of nanoparticles that adsorb glycoproteins, glycopeptides, or glycans.
    Type: Application
    Filed: August 26, 2024
    Publication date: August 28, 2025
    Inventors: Bruce WILCOX, Philip MA, Kavya SWAMINATHAN, Chi-Hung LIN
  • MULTI-OMIC ASSESSMENT
    Publication number: 20250273293
    Abstract: Described herein are methods such as multi-omic methods for assessing a disease such as cancer. The multi-omic methods may integrate proteomic, transcriptomic, genomic, lipidomic, or metabolomic data. The method screening diseases or disease states. Also described herein are methods for screening for diseases or disease states from biological samples. The methods may include assessing whether a nodule, mass, or cyst is cancerous.
    Type: Application
    Filed: March 28, 2025
    Publication date: August 28, 2025
    Inventors: Philip MA, Bruce WILCOX, Francois COLLIN, Chinmay BELTHANGADY, Mi YANG, Manoj KHADKA, Manway LIU, John BLUME, Robert S. LANGER, JR., Ehdieh KHALEDIAN
  • METHODS FOR IDENTIFYING OR QUANTITATING PEPTIDES
    Publication number: 20250271448
    Abstract: Provided are methods comprising combining a biological sample with a double-labeled peptide standard comprising a peptide comprising a first label and comprising a post-translational modification (PTM) comprising a second label; and identifying or measuring, based on the double-labeled peptide standard, an endogenous protein of the biological sample, wherein the endogenous protein comprises the PTM. Further, provided are methods and devices for enriching and/or purifying glycan-modified macromolecules with higher specificity and sensitivity.
    Type: Application
    Filed: May 7, 2025
    Publication date: August 28, 2025
    Inventors: Chi-Hung LIN, Bruce WILCOX
  • Direct classification of raw biomolecule measurement data
    Patent number: 12387508
    Abstract: Disclosed herein are systems and methods for direct classification of biological datasets. The datasets may include raw mass spectrometry data. Some aspects include training a classifier for direct classification of raw data, and some aspects include applying the classifier.
    Type: Grant
    Filed: September 8, 2022
    Date of Patent: August 12, 2025
    Assignee: PrognomIQ, Inc.
    Inventors: Manway Liu, Chinmay Belthangady, Bruce Wilcox, Philip Ma, Joon-Yong Lee, Hyungseok Kim
  • Multi-omic assessment using proteins and nucleic acids
    Patent number: 12334190
    Abstract: Described herein are methods such as multi-omic methods for assessing a disease such as cancer. The multi-omic methods may integrate proteomic, transcriptomic, genomic, lipidomic, or metabolomic data. The method screening diseases or disease states. Also described herein are methods for screening for diseases or disease states from biological samples. The methods may include assessing whether a nodule, mass, or cyst is cancerous.
    Type: Grant
    Filed: March 30, 2022
    Date of Patent: June 17, 2025
    Assignee: PROGNOMIQ, INC.
    Inventors: Philip Ma, Bruce Wilcox, Francois Collin, Chinmay Belthangady, Mi Yang, Manoj Khadka, Manway Liu, John Blume, Robert S. Langer, Jr., Ehdieh Khaledian
  • ENHANCED DETECTION AND QUANTITATION OF BIOMOLECULES
    Publication number: 20250093363
    Abstract: Described herein are methods for screening for a disease state. The method may include obtaining multiple data sets and identifying the disease state based on a combination of the data sets. The data sets may include biomolecule measurements obtained by multiple methods, such as through the use of particles and reference biomolecules.
    Type: Application
    Filed: April 23, 2024
    Publication date: March 20, 2025
    Inventors: Bruce WILCOX, Kavya SWAMINATHAN, Preston B. WILLIAMS, Jared DEYARMIN, Mi YANG
  • BIOMARKER DATABASE GENERATION AND USE
    Publication number: 20250027952
    Abstract: Databases methods and reagents are disclosed for the generation of large amounts of biomarker data from readily obtained sample such as dried plasma spots, and for uses of such databases in the development of patient categorization or detection of changes in a patient's health status over time.
    Type: Application
    Filed: October 4, 2024
    Publication date: January 23, 2025
    Inventors: John Blume, Ryan Benz, Jeffrey Jones, William F. Smith, Phong Cun, Bruce Wilcox
  • Biomarker Database Generation and Use
    Publication number: 20240201201
    Abstract: Databases methods and reagents are disclosed for the generation of large amounts of biomarker data from readily obtained sample such as dried plasma spots, and for uses of such databases in the development of patient categorization or detection of changes in a patient's health status over time.
    Type: Application
    Filed: January 18, 2024
    Publication date: June 20, 2024
    Inventors: John Blume, Ryan Benz, Jeffrey Jones, William Smith, Phong Cun, Bruce Wilcox
  • Enhanced detection and quantitation of biomolecules
    Patent number: 12007397
    Abstract: Described herein are methods for screening for a disease state. The method may include obtaining multiple data sets, and identifying the disease state based on a combination of the data sets. The data sets may include biomolecule measurements obtained by multiple methods, such as through the use of particles and reference biomolecules.
    Type: Grant
    Filed: September 12, 2022
    Date of Patent: June 11, 2024
    Assignee: PrognomiQ, Inc.
    Inventors: Bruce Wilcox, Kavya Swaminathan, Preston B. Williams, Jared Deyarmin, Mi Yang
  • MULTI-OMIC ASSESSMENT
    Publication number: 20230223111
    Abstract: Described herein are methods such as multi-omic methods for assessing a disease such as cancer. The multi-omic methods may integrate proteomic, transcriptomic, genomic, lipidomic, or metabolomic data. The method screening diseases or disease states. Also described herein are methods for screening for diseases or disease states from biological samples. The methods may include assessing whether a nodule, mass, or cyst is cancerous.
    Type: Application
    Filed: February 3, 2023
    Publication date: July 13, 2023
    Inventors: Philip Ma, Bruce Wilcox, Francois Collin, Chinmay Belthangady, Mi Yang, Manoj Khadka, Manway Liu, John Blume, Robert S. Langer, JR., Ehdieh Khaledian
  • MULTI-OMIC ASSESSMENT
    Publication number: 20230187028
    Abstract: Described herein are methods such as multi-omic methods for assessing a disease such as cancer. The multi-omic methods may integrate proteomic, transcriptomic, genomic, lipidomic, or metabolomic data. The method screening diseases or disease states. Also described herein are methods for screening for diseases or disease states from biological samples. The methods may include assessing whether a nodule, mass, or cyst is cancerous.
    Type: Application
    Filed: January 5, 2023
    Publication date: June 15, 2023
    Inventors: Philip Ma, Bruce Wilcox, Francois Collin, Chinmay Belthangady, Mi Yang, Manoj Khadka, Manway Liu, John Blume, Robert S. Langer, JR., Ehdieh Khaledian
  • DIRECT CLASSIFICATION OF RAW BIOMOLECULE MEASUREMENT DATA
    Publication number: 20230178176
    Abstract: Disclosed herein are systems and methods for direct classification of biological datasets. The datasets may include raw mass spectrometry data. Some aspects include training a classifier for direct classification of raw data, and some aspects include applying the classifier.
    Type: Application
    Filed: February 6, 2023
    Publication date: June 8, 2023
    Inventors: Manway Liu, Chinmay Belthangady, Bruce Wilcox, Philip Ma, Joon-Yong Lee, Hyungseok Kim
  • ENHANCED DETECTION AND QUANTITATION OF BIOMOLECULES
    Publication number: 20230145645
    Abstract: Described herein are methods for screening for a disease state. The method may include obtaining multiple data sets, and identifying the disease state based on a combination of the data sets. The data sets may include biomolecule measurements obtained by multiple methods, such as through the use of particles and reference biomolecules.
    Type: Application
    Filed: January 10, 2023
    Publication date: May 11, 2023
    Inventors: Bruce Wilcox, Kavya Swaminathan, Preston B. Williams, Jared Deyarmin, Mi Yang
  • ENHANCED DETECTION AND QUANTITATION OF BIOMOLECULES
    Publication number: 20230089033
    Abstract: Described herein are methods for screening for a disease state. The method may include obtaining multiple data sets, and identifying the disease state based on a combination of the data sets. The data sets may include biomolecule measurements obtained by multiple methods, such as through the use of particles and reference biomolecules.
    Type: Application
    Filed: September 12, 2022
    Publication date: March 23, 2023
    Inventors: Bruce Wilcox, Kavya Swaminathan, Preston B. Williams, Jared Deyarmin, Mi Yang
  • DIRECT CLASSIFICATION OF RAW BIOMOLECULE MEASUREMENT DATA
    Publication number: 20230080329
    Abstract: Disclosed herein are systems and methods for direct classification of biological datasets. The datasets may include raw mass spectrometry data. Some aspects include training a classifier for direct classification of raw data, and some aspects include applying the classifier.
    Type: Application
    Filed: September 8, 2022
    Publication date: March 16, 2023
    Inventors: Manway Liu, Chinmay Belthangady, Bruce Wilcox, Philip Ma, Joon-Yong Lee, Hyungseok Kim