Patents by Inventor Bruno Antonsson

Bruno Antonsson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 9-(piperazinylalkyl) carbazoles as Bax-modulators
    Patent number: 8410110
    Abstract: Piperazine compounds for use as pharmaceutically active compounds and in pharmaceutical formulations that are useful for the treatment of disorders associated with apoptosis, including neurodegenerative disorders, diseases associated with polyglutamine tracts, epilepsy, ischemia, infertility, cardiovascular disorders, renal hypoxia, hepatitis and AIDS, where the piperazine compounds are represented by formula (I) and the terms R0, R1, R2, R3, k, l, m, n, and X are defined herein:
    Type: Grant
    Filed: September 6, 2011
    Date of Patent: April 2, 2013
    Assignee: Merck Serono SA
    Inventors: Serge Halazy, Dennis Church, Bruno Antonsson, Agnes Bombrun, Patrick Gerber, Jean-Claude Martinou
  • 9-(PIPERAZINYLALKYL) CARBAZOLES AS BAX-MODULATORS
    Publication number: 20120040933
    Abstract: piperazine compounds for use as pharmaceutically active compounds and in pharmaceutical formulations that are useful for the treatment of disorders associated with apoptosis, including neurodegenerative disorders, diseases associated with polyglutamine tracts, epilepsy, ischemia, infertility, cardiovascular disorders, renal hypoxia, hepatitis and AIDS, where the piperazine compounds are represented by formula (I) and the terms R0, R1, R2, R3, k, l, m, n, and X are defined herein:
    Type: Application
    Filed: September 6, 2011
    Publication date: February 16, 2012
    Applicant: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
    Inventors: Serge HALAZY, Dennis Church, Bruno Antonsson, Agnes Bombrun, Patrick Gerber, Jean-Claude Martinou
  • 9-(piperazinylalkyl) carbazoles as bax-modulators
    Patent number: 8053436
    Abstract: The present invention is related to piperazine derivatives of carbazole of formula (I) notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such piperazine derivatives of carbazole. Said piperazine derivatives of carbazole are efficient modulators, in particular efficient inhibitors, of the Bax function and/or activation. The present invention is furthermore related to novel piperazine derivatives of carbazole as well as methods of their preparation.
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: November 8, 2011
    Assignee: Merck Serono SA
    Inventors: Serge Halazy, Dennis Church, Bruno Antonsson, Agnes Bombrun, Patrick Gerber, Jean-Claude Martinou
  • Use of an Immunoglobulin Domain-Containing Cell Surface Recognition Molecule For Treating Diseases
    Publication number: 20080193414
    Abstract: The invention relates to the use of INSP052 for treatment and/or prevention of infectious disease, properdin-related disease, MBL2-related disease, MASP1-related disease, MASP2-related disease, Antithrombin III-related disease, Complement factor H-related disease and/or Albumin-related disease. Combinations of INSP052 with an interferon, a TNF antagonist or a further anti-infectious or anti-blood clotting agent are also within the present invention.
    Type: Application
    Filed: May 4, 2006
    Publication date: August 14, 2008
    Inventors: Amanda Proudfoot, Bruno Antonsson, Linda Kontula, Francis Vilbois
  • Amine derivatives for the treatment of apoptosis
    Patent number: 6770656
    Abstract: The present invention is related to substituted amine derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such amine derivatives of formula (I). Said substituted amine derivatives are efficient modulators, in particular inhibitors, of the Bax function and/or activation. The present invention is furthermore related to novel substituted amine derivatives as well as methods of their preparation.
    Type: Grant
    Filed: December 26, 2002
    Date of Patent: August 3, 2004
    Assignee: Applied Research Systems ARS Holding N.V.
    Inventors: Serge Halazy, Matthias Schwarz, Bruno Antonsson, Agnes Bombrun, Jean-Claude Martinou, Dennis Church
  • Amine derivatives for the treatment of apoptosis
    Publication number: 20030216427
    Abstract: The present invention is related to substituted amine derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such amine derivatives of formula (I). Said substituted amine derivatives are efficient modulators, in particular inhibitors, of the Bax function and/or activation. The present invention is furthermore related to novel substituted amine derivatives as well as methods of their preparation.
    Type: Application
    Filed: December 26, 2002
    Publication date: November 20, 2003
    Inventors: Serge Halazy, Matthias Schwarz, Bruno Antonsson, Agnes Bombrun, Jean-Claude Martinou, Dennis Church
  • Bax protein channel formation
    Patent number: 6022720
    Abstract: The present invention relates, in general, to a protein that regulates programmed cell death and, in particular, to the pro-apoptotic protein, Bax, which forms channels in lipid membranes. The invention further relates to methods of identifying agonists and antagonists of Bax channel formation and/or activity and thereby agents that can be used therapeutically to promote or inhibit cell death.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: February 8, 2000
    Assignee: Glaxo Wellcome Inc.
    Inventors: Jean-Claude Martinou, Remy Sadoul, Bruno Antonsson, Franco Conti, Gonzalo Mazzei