Patents by Inventor Bruno Botta

Bruno Botta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF ANTIBIOTIC RESISTANCE MEDIATED BY ARNT
    Publication number: 20220259249
    Abstract: The present invention relates to diterpene compounds of general formula (I) capable of contrasting the antibiotic-resistance mediated by the ArnT enzyme, to their use as a medicament, in particular for use as an adjuvant of an antibiotic therapy in the treatment of antibiotic-resistant bacterial infections. The invention relates also to associations of one or more of the compounds of formula (I) with at least another active ingredient, in particular an antibacterial agent and/or an antibiotic, and compositions comprising one or more compounds of formula (I) or the association according to the present invention and at least one pharmaceutically acceptable excipient and/or carrier as well as to products, in particular medical devices, comprising at least a compound, an association or a composition according to the present invention.
    Type: Application
    Filed: July 24, 2020
    Publication date: August 18, 2022
    Applicants: UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA", FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
    Inventors: Francesco IMPERI, Fiorentina ASCENZIONI, Mattia MORI, Francesca GHIRGA, Deborah QUAGLIO, Silvia CORRADI, Alessandra LO SCIUTO, Bruno BOTTA, Andrea CALCATERRA, Roberta STEFANELLI
  • NOTCH INHIBITORS FOR USE IN THE TREATMENT OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
    Publication number: 20210363121
    Abstract: Compounds of formula (I) in the capacity of compounds with anti-tumor activity for the treatment of T-cell acute lymphoblastic leukemia (T-ALL).
    Type: Application
    Filed: August 9, 2021
    Publication date: November 25, 2021
    Inventors: Bruno Botta, Isabella Screpanti, Luca Tottone, Nadezda Zhdanoskaya, Cinzia Ingallina, Francesca Giulimondi, Deborah Quaglio, Rocco Palermo, Mattia Mori, Francesca Ghirga
  • Notch inhibitors for use in the treatment of t-cell acute lymphoblastic leukemia
    Patent number: 11104657
    Abstract: Compounds of formula (I) in the capacity of compounds with anti-tumor activity for the treatment of T-cell acute lymphoblastic leukemia (T-ALL).
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: August 31, 2021
    Assignees: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA, UNIVERSITÀ DEGLI STUDI DI ROMA “LA SAPIENZA”
    Inventors: Bruno Botta, Isabella Screpanti, Luca Tottone, Nadezda Zhdanoskaya, Cinzia Ingallina, Francesca Giulimondi, Deborah Quaglio, Rocco Palermo, Mattia Mori, Francesca Ghirga
  • COMPOUNDS FOR USE IN THE TREATMENT OF BRAIN DISEASES
    Publication number: 20210030714
    Abstract: The present invention relates to a compound of formula (1): or an analogue thereof or a pharmaceutically acceptable salt thereof, for use in the treatment of a brain tumor, wherein the compound is administered intranasally and relative pharmaceutical compositions.
    Type: Application
    Filed: February 5, 2019
    Publication date: February 4, 2021
    Applicants: UNIVERSITA DEGLI STUDI DI ROMA "LA SAPIENZA", FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA, UNIVERSITA DEGLIS STUDI DI PADOVA
    Inventors: Cristina LIMATOLA, Giuseppina D'ALESSANDRO, Lucia DI MARCOTULLIO, Paola INFANTE, Bruno BOTTA, Mattia MORI, Francesca GHIRGA, Cinzia INGALLINA, Simone BERARDOZZI, Paolo CALICETI, Stefano SALMASO, Michela DE MARTINO, Francesco GASPARRINI, Deborah QUAGLIO
  • NOTCH INHIBITORS FOR USE IN THE TREATMENT OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
    Publication number: 20190337916
    Abstract: Compounds of formula (I) in the capacity of compounds with anti-tumor activity for the treatment of T-cell acute lymphoblastic leukemia (T-ALL).
    Type: Application
    Filed: December 20, 2017
    Publication date: November 7, 2019
    Inventors: Bruno Botta, Isabella Screpanti, Luca Tottone, Nadezda Zhdanoskaya, Cinzia Ingallina, Francesca Giulimondi, Deborah Quaglio, Rocco Palermo, Mattia Mori, Francesca Ghirga
  • Multitarget hedgehog pathway inhibitors and uses thereof
    Patent number: 10093642
    Abstract: The present invention concerns compounds that selectively inhibit the activity of the Hedgehog (Hh) pathway, their preparation and uses thereof. The compounds of the present invention are useful in treating Hh-dependent tumors, such as medulloblastoma (MB).
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: October 9, 2018
    Assignees: UNIVERSITÀ DEGLI STUDI DI ROMA “LA SAPIENZA”, UNIVERSITA DEGLI STUDI DI SIENA
    Inventors: Bruno Botta, Alberto Gulino, Maurizio Botta, Mattia Mori, Lucia Di Marcotullio, Paola Infante, Francesca Ghirga, Sara Toscano, Cinzia Ingallina, Romina Alfonsi
  • MULTITARGET HEDGEHOG PATHWAY INHIBITORS AND USES THEREOF
    Publication number: 20160368886
    Abstract: The present invention concerns compounds that selectively inhibit the activity of the Hedgehog (Hh) pathway, their preparation and uses thereof. The compounds of the present invention are useful in treating Hh-dependent tumors, such as medulloblastoma (MB).
    Type: Application
    Filed: June 25, 2014
    Publication date: December 22, 2016
    Applicant: Universita' Degli Studi di Siena
    Inventors: Bruno BOTTA, Alberto GULINO, Maurizio BOTTA, Mattia MORI, Lucia DI MARCOTULLIO, Paola INFANTE, Francesca GHIRGA, Sara TOSCANO, Cinzia INGALLINA, Romina ALFONSI
  • Guanidine derivatives having hypotensive activity, composition containing them and process for obtaining them
    Patent number: 5059624
    Abstract: Guanidine derivatives of the following formulas (1) and (2): ##STR1## wherein: R.sup.1 is hydrogen or optionally substituted cinnamoyl,R.sup.2 is hydrogen, alkyl or alkenyl, with the proviso that R.sup.1 and R.sup.2 cannot be both hydrogen,n is an integer from 1 to 8, or: ##STR2## wherein R.sup.3 is truxinoyl or a truxilloyl each optionally substituted, andR.sup.2 and n are as defined above;pharmaceutical compositions containing such compounds and a process for their extraction and purification from plant material, in particular from Verbesina caracasana.
    Type: Grant
    Filed: February 24, 1989
    Date of Patent: October 22, 1991
    Assignee: Consiglio Nazionale Delle Ricerche
    Inventors: Giuliano D. Monache, Franco D. Monache, Marco Carmignani, Stella C. Bonnevaux, Romulo Espinal, Carlo De Luca, Bruno Botta