Patents by Inventor Bruno Bruni Ercole

Bruno Bruni Ercole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chimpanzee adenovirus vaccine carriers
    Patent number: 8673319
    Abstract: The present invention provides recombinant replication-defective adenoviral vectors derived from chimpanzee adenoviruses and methods for generating recombinant adenoviruses in human E1-expressing cell lines. The invention also provides compositions and methods suitable for use for the delivery and expression of transgenes encoding immunogens against which a boosted immune response is desired. The invention further provides methods of generating clinical grade vector stocks suitable for use in humans. In a particular embodiment the invention contemplates the use of vectors comprising transgenes which encode tumor associated antigens in vaccines and pharmaceutical compositions for the prevention and treatment of cancer.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: March 18, 2014
    Assignee: MSD Italia SRL
    Inventors: Stefano Colloca, Alfredo Nicosia, Agostino Cirillo, Bruno Bruni Ercole, Annalisa Meola, Paolo Palazzolo
  • CHIMPANZEE ADENOVIRUS VACCINE CARRIERS
    Publication number: 20120328651
    Abstract: The present invention provides recombinant replication-defective adenoviral vectors derived from chimpanzee adenoviruses and methods for generating recombinant adenoviruses in human E1-expressing cell lines. The invention also provides compositions and methods suitable for use for the delivery and expression of transgenes encoding immunogens against which a boosted immune response is desired. The invention further provides methods of generating clinical grade vector stocks suitable for use in humans. In a particular embodiment the invention contemplates the use of vectors comprising transgenes which encode tumor associated antigens in vaccines and pharmaceutical compositions for the prevention and treatment of cancer.
    Type: Application
    Filed: June 21, 2012
    Publication date: December 27, 2012
    Inventors: Stefano Colloca, Alfredo Nicosia, Elisabetta Sporeno, Agostino Cirillo, Bruno Bruni Ercole, Annalisa Meola, Paolo Palazzolo
  • Chimpanzee adenovirus vaccine carriers
    Patent number: 8216834
    Abstract: The present invention provides recombinant replication-defective adenoviral vectors derived from chimpanzee adenoviruses and methods for generating recombinant adenoviruses in human E1-expressing cell lines. The invention also provides compositions and methods suitable for use for the delivery and expression of transgenes encoding immunogens against which a boosted immune response is desired. The invention further provides methods of generating clinical grade vector stocks suitable for use in humans. In a particular embodiment the invention contemplates the use of vectors comprising transgenes which encode tumor associated antigens in vaccines and pharmaceutical compositions for the prevention and treatment of cancer.
    Type: Grant
    Filed: January 18, 2005
    Date of Patent: July 10, 2012
    Assignee: Istituto di Ricerche di Biologia Molecolare P. Angeletti SPA
    Inventors: Stefano Colloca, Alfredo Nicosia, Elisabetta Sporeno, Paolo Palazzolo, legal representative, Agostino Cirillo, Bruno Bruni Ercole, Annalisa Meola
  • Chimpanzee Adenovirus Vaccine Carriers
    Publication number: 20110217332
    Abstract: The present invention provides recombinant replication-defective adenoviral vectors derived from chimpanzee adenoviruses and methods for generating recombinant adenoviruses in human E1-expressing cell lines. The invention also provides compositions and methods suitable for use for the delivery and expression of transgenes encoding immunogens against which a boosted immune response is desired. The invention further provides methods of generating clinical grade vector stocks suitable for use in humans. In a particular embodiment the invention contemplates the use of vectors comprising transgenes which encode tumor associated antigens in vaccines and pharmaceutical compositions for the prevention and treatment of cancer.
    Type: Application
    Filed: January 18, 2005
    Publication date: September 8, 2011
    Inventors: Stefano Colloca, Alfredo Nicosia, Elisabetta Sporeno, Paolo Palazzolo, Agostino Cirillo, Bruno Bruni Ercole, Annalisa Meola