Patents by Inventor Bruno Buehler

Bruno Buehler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230183756
    Abstract: The invention relates to a method for extracting oxygen form a reaction chamber, as well as a use of microorganisms in such a method and a photobioreactor for carrying out the method. According to the invention, the method comprises the steps—irradiating at least one phototropic microorganism with light under anaerobic conditions in a reaction chamber, and—in situ bonding of produced oxygen by means of the microorganism by oxidation of an oxygen-utilizing substrates.
    Type: Application
    Filed: March 6, 2018
    Publication date: June 15, 2023
    Inventors: Andreas Schmid, Anna Hoschek, Bruno Buehler
  • Publication number: 20200370080
    Abstract: What is described herein refers to isolated nucleic acid fragments encoding an oxygenase subunit (StyA) and a reductase subunit (StyB), wherein the polypeptide encoded for by the nucleotide sequence for the oxygenase subunit (StyA) and the nucleotide sequence for the reductase subunit (StyB) have activity towards chiral arylsulfides.
    Type: Application
    Filed: July 12, 2018
    Publication date: November 26, 2020
    Inventors: Rainhard KOCH, Simon KLAFFL, Markus SPELBERG, Dirk TISCHLER, Michael SCHLOEMANN, Anika SCHOLTISSEK, Thomas HEINE, Bruno BUEHLER, Andreas SCHMID, Christian WILLRODT
  • Patent number: 10343130
    Abstract: A method processes a stable emulsion having components from whole-cell biotransformations such as cells, soluble cell components, organic solvents and/or water. In this connection, the emulsion, which is stable after the biotransformation, is mixed with further parts of organic phase, and subsequently the mixture is continuously stirred until a catastrophic phase inversion of the emulsion takes place while mixing; subsequently, this phase-inverted mixture is transferred to a settling container, where the phases of the emulsion separate from one another and can be separated from one another.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: July 9, 2019
    Assignee: Technische Universitaet Dortmund
    Inventors: Christoph Brandenbusch, Gabriele Sadowski, Bruno Buehler, Jonathan A. Collins
  • Patent number: 9200043
    Abstract: The invention provides a biocatalytic process for oxidation of organic compounds with the aid of an alkL gene product, and microorganisms used in this process.
    Type: Grant
    Filed: March 15, 2011
    Date of Patent: December 1, 2015
    Assignee: Evonik Degussa GmbH
    Inventors: Markus Pötter, Andreas Schmid, Bruno Bühler, Hans-Georg Hennemann, Mattijs Kamiel Julsing, Steffen Schaffer, Thomas Haas, Manfred Schrewe, Sjef Cornelissen, Martin Roos, Harald Häger
  • Publication number: 20150125931
    Abstract: A method processes a stable emulsion having components from whole-cell biotransformations such as cells, soluble cell components, organic solvents and/or water. In this connection, the emulsion, which is stable after the biotransformation, is mixed with further parts of organic phase, and subsequently the mixture is continuously stirred until a catastrophic phase inversion of the emulsion takes place while mixing; subsequently, this phase-inverted mixture is transferred to a settling container, where the phases of the emulsion separate from one another and can be separated from one another.
    Type: Application
    Filed: November 5, 2014
    Publication date: May 7, 2015
    Applicant: TECHNISCHE UNIVERSITAET DORTMUND
    Inventors: Christoph BRANDENBUSCH, Gabriele SADOWSKI, Bruno BUEHLER, Jonathan A. COLLINS
  • Patent number: 9012227
    Abstract: The present invention relates to a cell, which has been genetically modified relative to its wild type, so that in comparison with its wild type it is able to produce more ?-aminocarboxylic acids, more ?-aminocarboxylic acid esters or more lactams derived from ?-aminocarboxylic acids, starting from carboxylic acids or carboxylic acid esters. Furthermore, the present invention relates to a method for the production of a genetically modified cell, the cells obtainable by this method, a method for the production of ?-aminocarboxylic acids, of ?-aminocarboxylic acid esters or of lactams derived from ?-aminocarboxylic acids, the ?-aminocarboxylic acids, ?-aminocarboxylic acid esters or lactams derived from ?-aminocarboxylic acids obtainable by this method, a method for the production of polyamides based on ?-aminocarboxylic acids or based on lactams and the polyamides obtainable by this method.
    Type: Grant
    Filed: December 12, 2008
    Date of Patent: April 21, 2015
    Assignee: Evonik Degussa GmbH
    Inventors: Andreas Karau, Volker Sieber, Thomas Haas, Harald Haeger, Katrin Grammann, Bruno Buehler, Lars Blank, Andreas Schmid, Guido Jach, Bernd Lalla, Andreas Mueller, Katrin Schullehner, Peter Welters, Thorsten Eggert, Andrea Weckbecker
  • Patent number: 8431358
    Abstract: The method separates emulsions derived from whole-cell biotransformations, including stable emulsions derived from typical biocatalytic two-phase processes that result with such a biotransformation. A supercritical extraction to obtain the valuable product can follow directly, because of the use of compressed or supercritical gas as the separation agent. It is unimportant whether the valuable product is present in the aqueous or the organic phase. Recycling of the organic phase is possible, since the surfactant cell components decisively responsible for the formation of the stable emulsion can be separated off via sedimentation, because of the treatment. The achieved separation remains in existence even after the gas has gassed out, so that aside from extraction, other methods for product isolation can also follow, if necessary.
    Type: Grant
    Filed: July 20, 2008
    Date of Patent: April 30, 2013
    Assignee: Technische Universitaet Dortmund
    Inventors: Gabriele Sadowski, Andreas Schmid, Bruno Buehler, Michael Goernert, Christoph Brandenbusch
  • Publication number: 20130052700
    Abstract: The invention provides a biocatalytic process for oxidation of organic compounds with the aid of an alkL gene product, and microorganisms used in this process.
    Type: Application
    Filed: March 15, 2011
    Publication date: February 28, 2013
    Inventors: Markus Poetter, Andreas Schmid, Bruno Buehler, Hans-Georg Hennemann, Mattijs Kamiel Julsing, Steffen Schaffer, Thomas Haas, Manfred Schrewe, Sjef Cornelissen, Martin Roos, Harald Haeger
  • Publication number: 20100324257
    Abstract: The present invention relates to a cell, which has been genetically modified relative to its wild type, so that in comparison with its wild type it is able to produce more ?-aminocarboxylic acids, more ?-aminocarboxylic acid esters or more lactams derived from ?-aminocarboxylic acids, starting from carboxylic acids or carboxylic acid esters. Furthermore, the present invention relates to a method for the production of a genetically modified cell, the cells obtainable by this method, a method for the production of ?-aminocarboxylic acids, of ?-aminocarboxylic acid esters or of lactams derived from ?-aminocarboxylic acids, the ?-aminocarboxylic acids, ?-aminocarboxylic acid esters or lactams derived from ?-aminocarboxylic acids obtainable by this method, a method for the production of polyamides based on ?-aminocarboxylic acids or based on lactams and the polyamides obtainable by this method.
    Type: Application
    Filed: December 12, 2008
    Publication date: December 23, 2010
    Applicant: EVONIK DEGUSSA Gmbh
    Inventors: Andreas Karau, Volker Sieber, Thomas Haas, Harald Haeger, Katrin Grammann, Bruno Buehler, Lars Blank, Andreas Schmid, Guido Jach, Bernd Lalla, Andreas Mueller, Katrin Schullehner, Peter Welters, Thorsten Eggert, Andrea Weckbecker
  • Publication number: 20100145082
    Abstract: The method presented represents a possibility for separating emulsions derived from whole-cell biotransformations, which method makes it possible to effectively separate stable emulsions derived from typical biocatalytic two-phase processes that result in connection with such a biotransformation, by means of at least one compressed or supercritical gas. In this connection, a supercritical extraction to obtain the valuable product can follow directly, because of the use of compressed or supercritical gas as the separation agent. It is unimportant, in this connection, whether the valuable product is present in the aqueous or the organic phase. Recycling of the organic phase is possible, since the surfactant cell components, which are decisively responsible for the formation of the stable emulsion, can be separated off by means of sedimentation, because of the treatment.
    Type: Application
    Filed: July 20, 2008
    Publication date: June 10, 2010
    Inventors: Gabriele Sadowski, Andreas Schmid, Bruno Buehler, Michael Goernert, Christoph Brandenbusch
  • Patent number: 7368267
    Abstract: The invention relates to a process for the biocatalytic oxidation of aromatic compounds using recombinant xylene monooxygenase-expressing microorganisms in a biphasic reaction medium.
    Type: Grant
    Filed: April 5, 2002
    Date of Patent: May 6, 2008
    Assignee: BASF Aktiengesellschaft
    Inventors: Andreas Schmid, Bernhard Witholt, Bruno Bühler, Bernhard Hauer, Thomas Zelinski
  • Publication number: 20050060066
    Abstract: A device (10) having a first vehicle (11) and a second vehicle (13) which are connected to one another via a communication link (12). The first vehicle (11) has operational units (21), which are actuated in the typical way during driving. In the first vehicle (11), there are connections (23) for transmitting vehicle information (24) which is correlated to the actuation of the operational units (21). Switching means (28) are used for the purpose of switching over the first vehicle (11) from a driving mode into a remote operation mode. A transmitter (27) is used for converting the vehicle information (24) into signals and for transmitting the signals from the first vehicle (11) to the second vehicle (13). The second vehicle (13) includes a receiver (31) for receiving the signals and for converting them into control information.
    Type: Application
    Filed: July 22, 2004
    Publication date: March 17, 2005
    Applicant: Oerlikon Contraves AG
    Inventors: Bruno Buehler, Urban Thoeni