Patents by Inventor Bruno Cammue
Bruno Cammue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230414570Abstract: Provided herein are compositions for topical use comprising an imidazole or a salt thereof, and domiphen bromide as active ingredients for use in treating or preventing a fungal infection, wherein said imidazole is chosen from ketoconazole and clotrimazole as active ingredients for use in treating or preventing a fungal infection.Type: ApplicationFiled: September 13, 2023Publication date: December 28, 2023Applicants: Katholieke Universiteit Leuven, Universiteit AntwerpenInventors: Bruno Cammue, Karin Thevissen, Kaat De Cremer, Paul Cos
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Patent number: 11793790Abstract: The invention relates to compositions for topical use comprising miconazole or a salt thereof and domiphen bromide as active ingredients for use in treating or preventing a fungal infection.Type: GrantFiled: July 5, 2018Date of Patent: October 24, 2023Assignees: UNIVERSITEIT ANTWERPEN, KATHOLIEKE UNIVERSITEIT LEUVENInventors: Bruno Cammue, Karin Thevissen, Kaat De Cremer, Paul Cos
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Publication number: 20230242629Abstract: This disclosure relates to a transgenic plant or plant tissue. In particular, this disclosure relates to a transgenic plant or plant tissue or plant cell comprising at least one polynucleotide comprising at least one sequence encoding a variable domain of a heavy-chain antibody (VHH) specifically binding to a sphingolipid of a fungus. Advantageously, the expression of the polynucleotide in at least part of the transgenic plant or plant tissue or plant cell (i) protects at least part of the transgenic plant or plant tissue or plant cell from an infection with a plant pathogenic fungus, (ii) inhibits the growth of a plant pathogenic fungus on at least part of the transgenic plant or plant tissue or plant cell, or (iii) increases the resistance of at least part of the transgenic plant or plant tissue or plant cell against a plant pathogenic fungus.Type: ApplicationFiled: May 16, 2022Publication date: August 3, 2023Inventors: Peter Verheesen, Chris De Jonghe, Jan Geerinck, Inge Elodie Van Daele, Miguel Francesco Coleta De Bolle, João Filipe Veloso Vieira, Marnix Peferoen, Karin Thevissen, Bruno Cammue
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Publication number: 20230103644Abstract: The invention relates to 8-hydroxyquinolines or pharmaceutically acceptable salt thereof for use in the prevention or treatment of epilepsy.Type: ApplicationFiled: March 16, 2021Publication date: April 6, 2023Inventors: Bruno Cammue, Peter De Witte, Lieven Lagae, Karin Thevissen
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Publication number: 20220408733Abstract: The present invention relates to plant extracts and their use as biostimulant and biocontrol agent. More specific, the invention provides extracts of plants of the genus Helianthus which are capable of modifying root architecture and stimulate root development in plants. Hence, said extracts can be used to control plant development such as e.g. improve general root architecture, nutrient uptake and increase tolerance of plants to drought. In addition, these extracts can be used to control plant disease.Type: ApplicationFiled: November 13, 2020Publication date: December 29, 2022Inventors: Danny GEELEN, Philippe EVON, Bruno CAMMUE, Geert HAESAERT, Tina KYNDT, Stefaan WERBROUCK
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Publication number: 20210253677Abstract: This disclosure relates to agrochemical and biological control compositions for combating pests, more specifically plant pests, comprising at least one polypeptide, which specifically binds to a pest. The disclosure further provides methods for protecting or treating a plant or a part of a plant from an infection or other biological interaction with a plant pathogen, at least comprising the step of applying directly or indirectly to a plant or to a part of a plant, an agrochemical composition, under conditions effective to protect or treat a plant or a part of a plant against a infection or biological interaction with a plant pathogen. Further provided are methods for producing such agrochemical compositions and formulations, to polypeptides with a specific pesticidal activity comprised within an agrochemical formulation, to nucleic acids encoding such polypeptide and to plants comprising chimeric genes comprising such nucleic acids.Type: ApplicationFiled: January 15, 2021Publication date: August 19, 2021Inventors: Peter Verheesen, Chris De Jonghe, Inge Elodie Van Daele, Miguel Francesco Coleta De Bolle, João Filipe Veloso Vieira, Karin Thevissen, Bruno Cammue
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Patent number: 11028154Abstract: This disclosure relates to agrochemical and biological control compositions for combating pests, more specifically plant pests, comprising at least one polypeptide, which specifically binds to a pest. The disclosure further provides methods for protecting or treating a plant or a part of a plant from an infection or other biological interaction with a plant pathogen, at least comprising the step of applying directly or indirectly to a plant or to a part of a plant, an agrochemical composition, under conditions effective to protect or treat a plant or a part of a plant against a infection or biological interaction with a plant pathogen. Further provided are methods for producing such agrochemical compositions and formulations, to polypeptides with a specific pesticidal activity comprised within an agrochemical formulation, to nucleic acids encoding such polypeptide and to plants comprising chimeric genes comprising such nucleic acids.Type: GrantFiled: July 31, 2019Date of Patent: June 8, 2021Assignee: Biotalys NVInventors: Peter Verheesen, Chris De Jonghe, Inge Elodie Van Daele, Miguel Francesco Coleta De Bolle, João Filipe Veloso Vieira, Karin Thevissen, Bruno Cammue
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Publication number: 20200138786Abstract: The invention relates to compositions for topical use comprising miconazole or a salt thereof and domiphen bromide as active ingredients for use in treating or preventing a fungal infection.Type: ApplicationFiled: July 5, 2018Publication date: May 7, 2020Inventors: Bruno Cammue, Karin Thevissen, Kaat De Cremer, Paul Cos
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Publication number: 20190352379Abstract: This disclosure relates to agrochemical and biological control compositions for combating pests, more specifically plant pests, comprising at least one polypeptide, which specifically binds to a pest. The disclosure further provides methods for protecting or treating a plant or a part of a plant from an infection or other biological interaction with a plant pathogen, at least comprising the step of applying directly or indirectly to a plant or to a part of a plant, an agrochemical composition, under conditions effective to protect or treat a plant or a part of a plant against a infection or biological interaction with a plant pathogen. Further provided are methods for producing such agrochemical compositions and formulations, to polypeptides with a specific pesticidal activity comprised within an agrochemical formulation, to nucleic acids encoding such polypeptide and to plants comprising chimeric genes comprising such nucleic acids.Type: ApplicationFiled: July 31, 2019Publication date: November 21, 2019Inventors: Peter Verheesen, Chris De Jonghe, Inge Elodie Van Daele, Miguel Francesco Coleta De Bolle, João Filipe Veloso Vieira, Karin Thevissen, Bruno Cammue
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Patent number: 10400033Abstract: This disclosure relates to agrochemical and biological control compositions for combating pests, more specifically plant pests, comprising at least one polypeptide, which specifically binds to a pest. The disclosure further provides methods for protecting or treating a plant or a part of a plant from an infection or other biological interaction with a plant pathogen, at least comprising the step of applying directly or indirectly to a plant or to a part of a plant, an agrochemical composition, under conditions effective to protect or treat a plant or a part of a plant against a infection or biological interaction with a plant pathogen. Further provided are methods for producing such agrochemical compositions and formulations, to polypeptides with a specific pesticidal activity comprised within an agrochemical formulation, to nucleic acids encoding such polypeptide and to plants comprising chimeric genes comprising such nucleic acids.Type: GrantFiled: October 4, 2017Date of Patent: September 3, 2019Assignee: AGROSAVFE N.V.Inventors: Peter Verheesen, Chris De Jonghe, Inge Elodie Van Daele, Miguel Francesco Coleta De Bolle, João Filipe Veloso Vieira, Karin Thevissen, Bruno Cammue
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Publication number: 20180222966Abstract: This disclosure relates to a transgenic plant or plant tissue. In particular, this disclosure relates to a transgenic plant or plant tissue or plant cell comprising at least one polynucleotide comprising at least one sequence encoding a variable domain of a heavy-chain antibody (VHH) specifically binding to a sphingolipid of a fungus. Advantageously, the expression of the polynucleotide in at least part of the transgenic plant or plant tissue or plant cell (i) protects at least part of the transgenic plant or plant tissue or plant cell from an infection with a plant pathogenic fungus, (ii) inhibits the growth of a plant pathogenic fungus on at least part of the transgenic plant or plant tissue or plant cell, or (iii) increases the resistance of at least part of the transgenic plant or plant tissue or plant cell against a plant pathogenic fungus.Type: ApplicationFiled: March 20, 2018Publication date: August 9, 2018Inventors: Peter Verheesen, Chris De Jonghe, Jan Geerinck, Inge Elodie Van Daele, Miguel Francesco Coleta De Bolle, João Filipe Veloso Vieira, Marnix Peferoen, Karin Thevissen, Bruno Cammue
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Publication number: 20180022791Abstract: This disclosure relates to agrochemical and biological control compositions for combating pests, more specifically plant pests, comprising at least one polypeptide, which specifically binds to a pest. The disclosure further provides methods for protecting or treating a plant or a part of a plant from an infection or other biological interaction with a plant pathogen, at least comprising the step of applying directly or indirectly to a plant or to a part of a plant, an agrochemical composition, under conditions effective to protect or treat a plant or a part of a plant against a infection or biological interaction with a plant pathogen. Further provided are methods for producing such agrochemical compositions and formulations, to polypeptides with a specific pesticidal activity comprised within an agrochemical formulation, to nucleic acids encoding such polypeptide and to plants comprising chimeric genes comprising such nucleic acids.Type: ApplicationFiled: October 4, 2017Publication date: January 25, 2018Applicant: AGROSAVFE N.V.Inventors: Peter Verheesen, Chris De Jonghe, Inge Elodie Van Daele, Miguel Francesco Coleta De Bolle, João Filipe Veloso Vieira, Karin Thevissen, Bruno Cammue
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Patent number: 9803003Abstract: The present invention relates to agrochemical and biological control compositions for combating pests, more specifically plant pests, comprising at least one polypeptide, which specifically binds to a pest. The invention further provides methods for protecting or treating a plant or a part of a plant from an infection or other biological interaction with a plant pathogen, at least comprising the step of applying directly or indirectly to a plant or to a part of a plant, an agrochemical composition, under conditions effective to protect or treat a plant or a part of a plant against a infection or biological interaction with a plant pathogen. Further provided are methods for producing such agrochemical compositions and formulations, to polypeptides with a specific pesticidal activity comprised within an agrochemical formulation, to nucleic acids encoding such polypeptide and to plants comprising chimeric genes comprising such nucleic acids.Type: GrantFiled: April 29, 2014Date of Patent: October 31, 2017Assignee: AGROSAVFE N.V.Inventors: Peter Verheesen, Chris De Jonghe, Inge Elodie Van Daele, Miguel Francesco Coleta De Bolle, João Filipe Veloso Vieira, Karin Thevissen, Bruno Cammue
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Patent number: 9422573Abstract: Described are genes and chimeric genes encoding anti-microbial peptides. These genes can be used to generate transgenic plants with an improved resistance to, for example, plant pathogenic fungi. Alternatively, the peptides encoded by these genes can be applied as agrochemical formulations to plants suffering from microbial diseases such as fungal diseases.Type: GrantFiled: May 9, 2012Date of Patent: August 23, 2016Assignees: VIB VZW, Universiteit Gent, Katholieke Universiteit Leuven, K.U. Leuven R&DInventors: Frank Van Breusegem, Annelies Inze, Janick Mathys, Bruno Cammue
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Publication number: 20160145325Abstract: The present invention relates to agrochemical and biological control compositions for combating pests, more specifically plant pests, comprising at least one heavy chain variable domain of an antibody, which specifically binds to a sphingolipid of a plant pathogen. The invention further provides methods for protecting or treating a plant or a part of a plant from an infection or other biological interaction with a plant pathogen, at least comprising the step of applying directly or indirectly to a plant or to a part of a plant, an agrochemical composition, under conditions effective to protect or treat a plant or a part of a plant against a infection or biological interaction with a plant pathogen.Type: ApplicationFiled: April 29, 2014Publication date: May 26, 2016Applicant: AGROSAVFE N.V.Inventors: Peter Verheesen, Chris De Jonghe, Inge Elodie Van Daele, Miguel Francesco Coleta De Bolle, João Filipe Veloso Vieira, Karin Thevissen, Bruno Cammue
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Publication number: 20160075769Abstract: The present invention relates to agrochemical and biological control compositions for combating pests, more specifically plant pests, comprising at least one polypeptide, which specifically binds to a pest. The invention further provides methods for protecting or treating a plant or a part of a plant from an infection or other biological interaction with a plant pathogen, at least comprising the step of applying directly or indirectly to a plant or to a part of a plant, an agrochemical composition, under conditions effective to protect or treat a plant or a part of a plant against a infection or biological interaction with a plant pathogen. Further provided are methods for producing such agrochemical compositions and formulations, to polypeptides with a specific pesticidal activity comprised within an agrochemical formulation, to nucleic acids encoding such polypeptide and to plants comprising chimeric genes comprising such nucleic acids.Type: ApplicationFiled: April 29, 2014Publication date: March 17, 2016Inventors: Peter Verheesen, Chris De Jonghe, Inge Elodie Van Daele, Miguel Francesco Coleta De Bolle, João Filipe Veloso Vieira, Karin Thevissen, Bruno Cammue
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Publication number: 20140325703Abstract: Described are genes and chimeric genes encoding anti-microbial peptides. These genes can be used to generate transgenic plants with an improved resistance to, for example, plant pathogenic fungi. Alternatively, the peptides encoded by these genes can be applied as agrochemical formulations to plants suffering from microbial diseases such as fungal diseases.Type: ApplicationFiled: May 9, 2012Publication date: October 30, 2014Applicant: VIB VZWInventors: Frank Van Breusegem, Annelies Inze, Janick Mathys, Bruno Cammue
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Publication number: 20140079741Abstract: Treatment of a fungal biofilm on implants is via a combination of drugs and/or via the implant pre-treatment with one drug or via the combination of drugs.Type: ApplicationFiled: March 19, 2012Publication date: March 20, 2014Applicant: KATHOLIEKE UNIVERSITEIT LEUVEN KU LEUVEN RESEARCH & DEVELOPMENTInventors: Anna Bink, Bruno Cammue, Johan Martens, Bram Neirinck, Karin Thevissen, Jozef Vleugels
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Publication number: 20120252801Abstract: The present invention relates to a series of novel compounds which have been shown to possess antifungal activity. The invention therefore relates to the new compounds, methods for their preparation, pharmaceutical compositions comprising them and to the compounds for use as a medicament, more in particular antifungal medicament.Type: ApplicationFiled: December 15, 2010Publication date: October 4, 2012Applicant: Katholieke Universiteit Leuven, K.U.Leuven R&DInventors: Dorothée Bardiot, Bruno Cammue, Patrick Chaltin, Arnaud Marchand, Karin Thevissen
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Publication number: 20060148717Abstract: Biocidal proteins capable of isolation from seeds have been characterized. The proteins have an amino acid sequence containing the common cysteine/glycine domain of Chitin-binding Plant Proteins but show substantially better activity against pathogenic fungi, a higher ratio of basic amino acids to acidic amino acids, and/or antifungal activity which results in increased hyphal branching. Antimicrobial proteins isolated from Amaranthus, Capsicum, Briza and related species are provided. The proteins show a wide range of antifungal activity and are active against Gram-positive bacteria. DNA encoding the proteins may be isolated and incorporated into vectors. Plants may be transformed with this DNA. The proteins find agricultural or pharmaceutical application as antifungal or antibacterial agents. Transgenic plants expressing the protein will show increased disease resistance.Type: ApplicationFiled: December 18, 2002Publication date: July 6, 2006Inventors: Willem Broekaert, Bruno Cammue, Rupert Osborn, Sarah Rees, Josef Vanderleyden