Patents by Inventor Bruno Canard

Bruno Canard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8884011
    Abstract: This invention relates to a purine or pyrimidine phosphonate compound of formula (I) or pharmaceutically acceptable salt thereof; wherein B, X, and R1-R3 are as defined in classes and subclasses herein. These compounds may be used as antiviral precursors. The invention also relates to therapeutic compositions of these compounds and their use for the preparation of a medication for testing and/or preventing a viral infection in a patient. The invention also provides methods for making these compounds. In particular, the invention provides an H-phosphinate precursor intermediate of formula (II) wherein B is a purine or pyrimidine base as defined herein and R1 is selected from the group comprising a hydrogen atom, and a methyl, ethyl, hydroxymethyl, hydroxyethyl and C1-6haloalkyl group.
    Type: Grant
    Filed: November 8, 2007
    Date of Patent: November 11, 2014
    Assignees: Centre National de la Recherche Scientifique-CNRS, Universite d'Aix-Marseille, K.U. Leuven Research & Development
    Inventors: Bruno Canard, Karine Alvarez, Karine Barral, Jean-Louis Romette, Johan Neyts, Jan Balzarini
  • Patent number: 8030047
    Abstract: The isolation and purification of two domains from a from a flavivirus is provided. Each domain can function independently. Moreover, one domain codes for a sequence that provide polymerase activity. A process for screening possible modulators of the polymerase activity of an isolated and purified polypeptide from flavivirus is also disclosed.
    Type: Grant
    Filed: October 22, 2008
    Date of Patent: October 4, 2011
    Assignee: Centre National de la Recherche Scientifique-CNRS
    Inventors: Jean-Louis Romette, Bruno Canard, Marie-Pierre Egloff, Barbara Selisko, Delphine Benarroch
  • Publication number: 20100267113
    Abstract: The isolation and purification of two domains from a from a flavivirus is provided. Each domain can function independently. Moreover, one domain codes for a sequence that provide polymerase activity. A process for screening possible modulators of the polymerase activity of an isolated and purified polypeptide from flavivirus is also disclosed.
    Type: Application
    Filed: October 22, 2008
    Publication date: October 21, 2010
    Applicant: CENTRE NAT DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Jean-Louis ROMETTE, Bruno Canard, Marie-Pierre Egloff, Barbara Selisko, Delphine Benarroch
  • Publication number: 20100099869
    Abstract: This invention relates to a purine or pyrimidine phosphonate compound of formula (I) or pharmaceutically acceptable salt thereof; wherein B, X, and R1-R3 are as defined in classes and subclasses herein. These compounds may be used as antiviral precursors. The invention also relates to therapeutic compositions of these compounds and their use for the preparation of a medication for testing and/or preventing a viral infection in a patient. The invention also provides methods for making these compounds. In particular, the invention provides an H-phosphinate precursor intermediate of formula (II) wherein B is a purine or pyrimidine base as defined herein and R1 is selected from the group comprising a hydrogen atom, and a methyl, ethyl, hydroxymethyl, hydroxyethyl and C1-6haloalkyl group.
    Type: Application
    Filed: November 8, 2007
    Publication date: April 22, 2010
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, UNIVERSITE DE LA MEDITERRANEE, K.U. LEUVEN RESEARCH & DEVELOPMENT
    Inventors: Bruno Canard, Karine Alvarez, Karine Barral, Jean-Louis Romette, Johan Neyts, Jan Balzarini
  • Publication number: 20090221795
    Abstract: The isolation and purification of two domains from a from a flavivirus is provided. Each domain can function independently. Moreover, one domain codes for a sequence that provide polymerase activity. A process for screening possible modulators of the polymerase activity of an isolated and purified polypeptide from flavivirus is also disclosed.
    Type: Application
    Filed: October 22, 2008
    Publication date: September 3, 2009
    Applicant: CENTRE NAT DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Jean-Louis Romette, Bruno Canard, Marie-Pierre Egloff, Barbara Selisko, Delphine Benarroch
  • Patent number: 7459297
    Abstract: The isolation and purification of two domains from a from a flavivirus is provided. Each domain can function independently. Moreover, one domain codes for a sequence that provide polymerase activity. A process for screening possible modulators of the polymerase activity of an isolated and purified polypeptide from flavivirus is also disclosed.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: December 2, 2008
    Assignee: Centre National de la Recherche Scientifique -CNRS
    Inventors: Jean-Louis Romette, Bruno Canard, Marie-Pierre Egloff, Barbara Selisko, Delphine Benarroch
  • Patent number: 6949353
    Abstract: This invention concerns an isolated and purified polypeptide capable of acting as a guanylyltransferase and methyltransferase comprising capping enzyme of flavivirus (CEF). The invention also concerns the use of such polypeptide to identify biologically active molecule wich can be used in the treatment or the prevention of diseases resulting from Flavivirus infection.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: September 27, 2005
    Assignee: Centre National de la Recherche Scientifique, C.N.R.S.
    Inventors: Jean-Louis Romette, Delphine Benarroch, Bruno Canard, Marie-Pierre Egloff
  • Publication number: 20050100882
    Abstract: This invention concerns an isolated and purified polypeptide capable of acting as a guanylyltransferase and methyltransferase comprising capping enzyme of flavivirus (CEF). The invention also concerns the use of such polypeptide to identify biologically active molecule wich can be used in the treatment or the prevention of diseases resulting from Flavivirus infection.
    Type: Application
    Filed: May 31, 2002
    Publication date: May 12, 2005
    Inventors: Jean-Louis Romette, Delphine Benarroch, Bruno Canard, Marie-Pierre Egloff
  • Publication number: 20050048472
    Abstract: The isolation and purification of two domains from a from a flavivirus is provided. Each domain can function independently. Moreover, one domain codes for a sequence that provide polymerase activity. A process for screening possible modulators of the polymerase activity of an isolated and purified polypeptide from flavivirus is also disclosed.
    Type: Application
    Filed: May 28, 2004
    Publication date: March 3, 2005
    Inventors: Jean-Louis Romette, Bruno Canard, Marie-Pierre Egloff, Barbara Selisko, Delphine Benarroch
  • Patent number: 6001566
    Abstract: The invention is directed to the use of RNA or DNA polymerases having 3'-intrinsic editing activity (3'-IEA) in the presence or absence of a deactivating agent to remove a protecting group from the 3'-position of oligo- polyribo- or deoxyribonnucleotides. The use is connected with the incorporation of dNTPs into DNA templates in order to determine the concentration and/or sequence of said templates. In particular the use is concerned with an improved non gel-based sequencing method.
    Type: Grant
    Filed: May 31, 1996
    Date of Patent: December 14, 1999
    Assignee: Roche Diagnostics GmbH
    Inventors: Bruno Canard, Gregor Sagner
  • Patent number: 5798210
    Abstract: Deoxyribonucleotide 5' triphosphate (dNTP) or ribonucleotide 5' triphosphate (NTP) esters for use in a nucleic acid sequencing process without use of a gel and having one o formulae (I), (II), (III) or (IV).
    Type: Grant
    Filed: November 20, 1995
    Date of Patent: August 25, 1998
    Assignee: Institut Pasteur
    Inventors: Bruno Canard, Simon Sarfati