Patents by Inventor Bruno De Angelis

Bruno De Angelis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of sevelamer
    Patent number: 9303105
    Abstract: The present invention relates to a process for the preparation of sevelamer, in particular sevelamer hydrochloride and sevelamer carbonate/bicarbonate, by means of a process that allows sevelamer to be obtained with good yields and using conventional reactors, without requiring to use specific and expensive equipment.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: April 5, 2016
    Assignee: LABORATORIO CHIMICO INTERNAZIONALE S.P.A.
    Inventors: Flavio Villani, Bruno De Angelis, Antonio Nardi, Maria Paternoster
  • PROCESS FOR THE PREPARATION OF CRYSTALLINE FORM OF AGOMELATINE
    Publication number: 20150291508
    Abstract: The invention concerns a new process for the preparation of crystalline form I of agomelatine by freeze-drying.
    Type: Application
    Filed: August 3, 2011
    Publication date: October 15, 2015
    Applicant: LABORATORIO CHIMICO INTERNAZIONALE S.p.A.
    Inventors: Giorgio Bertolini, Bruno De Angelis
  • Process for the preparation of crystalline forms of agomelatine and novel polymorph thereof
    Patent number: 9024068
    Abstract: The invention concerns a new process for the preparation of crystalline form of agomelatine from a solution of agomelatine in a solvent, characterized in that the agomelatine is crystallized by instantaneous precipitation from said solution, at a temperature equal to or below ?10° C.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: May 5, 2015
    Assignee: Laboratorio Chimico Internazionale S.p.A.
    Inventors: Bruno De Angelis, Faris Garis, Salvatore De Gennaro, Giorgio Bertolini
  • Process for the manufacture of ivabradine and of intermediates of synthesis thereof
    Patent number: 9006424
    Abstract: The invention concerns a new process for the resolution of ivabradine and of intermediates of synthesis thereof.
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: April 14, 2015
    Assignee: Laboratorio Chimico Internazionale S.p.A.
    Inventors: Antonio Nardi, Bruno De Angelis, Paolangelo Cerea, Jane Llorenc Rafecas, Nicolas Tesson
  • PROCESS FOR THE MANUFACTURE OF IVABRADINE AND OF INTERMEDIATES OF SYNTHESIS THEREOF
    Publication number: 20140357859
    Abstract: The invention concerns a new process for the resolution of ivabradine and of intermediates of synthesis thereof.
    Type: Application
    Filed: July 31, 2012
    Publication date: December 4, 2014
    Applicant: LOBORATORIO CHIMICO INTERNAZIONALE S.p.A.
    Inventors: Antonio Nardi, Bruno De Angelis, Paolangelo Cerea, Jane Llorenc Rafecas, Nicolas Tesson
  • CRYSTALLINE FORM
    Publication number: 20140309293
    Abstract: The invention concerns a new polymorphic form of R-(+)-?-lipoic acid and a process for the preparation thereof, in addition to the compositions that contain it and its use as a medicine or food supplement.
    Type: Application
    Filed: July 6, 2012
    Publication date: October 16, 2014
    Applicant: LABORATORIO CHIMICO INTERNAZIONALE S.P. A.
    Inventors: Antonio Nardi, Annibale Salvi, Flavio Villani, Bruno De Angelis, Giorgio Bertolini
  • PROCESS FOR THE PREPARATION OF CRYSTALLINE FORMS OF AGOMELATINE AND NOVEL POLYMORPH THEREOF
    Publication number: 20140221690
    Abstract: The invention concerns a new process for the preparation of two crystalline forms of agomelatine, in particular a process for preparation of form I and a new form of agomelatine, here called form VII.
    Type: Application
    Filed: December 29, 2011
    Publication date: August 7, 2014
    Applicant: LABORATORIO CHIMICO
    Inventors: Bruno De Angelis, Faris Garis, Salvatore De Gennaro, Giorgio Bertolini
  • PROCESS FOR THE PREPARATION OF SEVELAMER
    Publication number: 20140213736
    Abstract: The present invention relates to a process for the preparation of sevelamer, in particular sevelamer hydrochloride and sevelamer carbonate/bicarbonate, by means of a process that allows sevelamer to be obtained with good yields and using conventional reactors, without requiring to use specific and expensive equipment.
    Type: Application
    Filed: February 6, 2014
    Publication date: July 31, 2014
    Applicant: LABORATORIO CHIMICO INTERNAZIONALE S.P.A.
    Inventors: Flavio VILLANI, Bruno DE ANGELIS, Antonio NARDI, Maria PATERNOSTER
  • Process for the preparation of (R)-(?)-3-(carbamoylmethyl)-5-methylhexanoic acid and of pregabalin and synthesis intermediates
    Patent number: 8563775
    Abstract: This invention relates to the preparation of (R)-(?)-3-(carbamoylmethyl)-5-methylhexanoic acid, in particular, the resolution of the acid racemate by means of salification with optically active amines and subsequent acidification to give the (R) enantiomer of the acid; this invention also concerns the salt intermediates formed with said amines and the conversion of said (R)-(?)-3-(carbamoylmethyl)-5-methylhexanoic acid into biologically active molecules such as pregabalin.
    Type: Grant
    Filed: June 6, 2007
    Date of Patent: October 22, 2013
    Assignee: Laboratorio Chimico Internazionale S.p.A.
    Inventors: Annibale Salvi, Antonio Nardi, Bruno De Angelis
  • PROCESS FOR THE PREPARATION OF SEVELAMER
    Publication number: 20120101234
    Abstract: The present invention relates to a process for the preparation of sevelamer, in particular sevelamer hydrochloride and sevelamer carbonate/bicarbonate, by means of a process that allows sevelamer to be obtained with good yields and using conventional reactors, without requiring to use specific and expensive equipment.
    Type: Application
    Filed: May 10, 2010
    Publication date: April 26, 2012
    Inventors: Flavio Villani, Bruno De Angelis, Antonio Nardi, Maria Paternoster
  • POLYMORPHIC FORM OF CALCIUM ACAMPROSATE
    Publication number: 20110182953
    Abstract: The present invention relates to a new polymorphic form of calcium acetyl-homotaurinate, designated as form B, and processes for the preparation of said form B and of the known crystalline form.
    Type: Application
    Filed: September 4, 2009
    Publication date: July 28, 2011
    Inventors: Annibale Salvi, Antonio Nardi, Bruno De Angelis
  • PROCESS FOR THE PREPARATION OF (R)-(-)-3-(CARBAMOYLMETHYL)-5-METHYLHEXANOIC ACID AND OF PREGABALIN AND SYNTHESIS INTERMEDIATES
    Publication number: 20090192331
    Abstract: This invention relates to the preparation of (R)-(?)-3-(carbamoylmethyl)-5- methylhexanoic acid, in particular, the resolution of the acid racemate by means of salification with optically active amines and subsequent acidification to give the (R) enantiomer of the acid; this invention also concerns the salt intermediates formed with said amines and the conversion of said (R)-(?)-3-(carbamoylmethyl)-5- methylhexanoic acid into biologically active molecules such as pregabalin.
    Type: Application
    Filed: June 6, 2007
    Publication date: July 30, 2009
    Inventors: Annibale Salvi, Antonio Nardi, Bruno De Angelis
  • Basic salt of thioctic acid with L-carnitine
    Patent number: 7235582
    Abstract: Salt of thioctic acid with L-carnitine with the formula: AY(X)x where A is where Y is the cation of an alkaline metal, of an alkaline earth metal or is a quaternary ammonium group, X is A or OH?, x is equal to 0 when Y is the cation of an alkaline metal or a quaternary ammonium group and equal to 1 when Y is an alkaline earth metal.
    Type: Grant
    Filed: November 3, 2003
    Date of Patent: June 26, 2007
    Assignee: Laboratorio Chimico Internazionale S.p.A.
    Inventors: Annibale Salvi, Flavio Villani, Antonio Nardi, Bruno De Angelis
  • Basic salt of thioctic acid with L-carnitine
    Publication number: 20040214879
    Abstract: Salt of thioctic acid with L-carnitine with the formula:
    Type: Application
    Filed: November 3, 2003
    Publication date: October 28, 2004
    Inventors: Annibale Salvi, Flavio Villani, Antonio Nardi, Bruno De Angelis