Abstract: A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6, 7-dihydro-7, 14-methanobenzimidazo[1, 2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.

Abstract: The present invention concerns a cell line comprising an endogenous dihydroorotate dehydrogenase (DHODH) and glutamine synthetase (GS) genes which are partially or fully inactivated, and its use for producing recombinant proteins.

Abstract: The elementary antenna 1 includes: two cross-shaped slots 32, 33 defining four half-slots; for each half-slot, excitation striplines 41, 42, the first stripline 41 being connected to a first via 61 and the second stripline 42 being connected to a second via 62; an integrated circuit 70 delivering a plurality of ports; for each half-slot, tracks for feeding the strips, the first track 51 running from a first port 71 to the first via 61 and the second track 52 running from a second port 72 to the second via 62, the first and second ports being two successive ports of the integrated circuit, differentially connected to a transmitter/receiver channel by first and second power lines situated inside the integrated circuit, the lines and tracks running so that there is no crossing of the respective routes thereof.

Abstract: An adaptive radio frequency including an input, an output, at least one fixed passive inductor and at least one variable active inductor connected between the input and the output.

Abstract: This elementary antenna includes a cavity delimited by front and rear faces and side walls, the front face being provided with first and second slots arranged in a cross, so that, when the cavity operates in a TE210 mode, a wave polarized perpendicularly to the first slot is emitted and when the cavity operates in a TE120 mode, a wave polarized perpendicularly to the second slot is emitted.

Abstract: The present invention concerns a cell line comprising an endogenous dehydroorotate dehydrogenase (DHODH) gene which is partially or fully inactivated, and its use for producing recombinant proteins.

Abstract: A transceiver device and associated antenna are disclosed. In one aspect, the transceiver device combines first and second transceiver modules with a transceiver capability including a substantially planar radiating element and including a central point. Each transceiver module is a transceiver module coupled with the transceiver capability so as to excite a pair of excitation points of the radiating element, the excitation points of one pair being arranged symmetrically relative to the central point of the radiating element. The first and second transceiver modules respectively excite a first pair of excitation points arranged in a first direction of the radiating element and a second pair of excitation points arranged in a second direction of the radiating element, the first and second directions being mutually orthogonal.

Abstract: Sample-and-hold device for an electrical signal including an input module having two inputs, including a first switching block including two input switches, each input of the input module being connected at the input of one of the input switches, the input module being connected at the input of a first track-and-hold module with two inputs and two outputs, so as to alternately convey the signal from one of the two inputs to one of the two inputs of the first track-and-hold module; the device including a second track-and-hold module connected in parallel with the first track-and-hold module, these track-and-hold modules connected at the output of the first switching block, and an output module including a second switching block including two output switches, the outputs of the first and second track-and-hold modules being connected to the inputs of the output switches, to time interleave the output signals of the track-and-hold modules.

Abstract: Sample-and-hold device for an electrical signal including an input module having two inputs, including a first switching block including two input switches, each input of the input module being connected at the input of one of the input switches, the input module being connected at the input of a first track-and-hold module with two inputs and two outputs, so as to alternately convey the signal from one of the two inputs to one of the two inputs of the first track-and-hold module; the device including a second track-and-hold module connected in parallel with the first track-and-hold module, these track-and-hold modules connected at the output of the first switching block, and an output module including a second switching block including two output switches, the outputs of the first and second track-and-hold modules being connected to the inputs of the output switches, to time interleave the output signals of the track-and-hold modules.

Abstract: A transceiver device and associated antenna are disclosed. In one aspect, the transceiver device combines first and second transceiver modules with a transceiver capability including a substantially planar radiating element and including a central point. Each transceiver module is a transceiver module coupled with the transceiver capability so as to excite a pair of excitation points of the radiating element, the excitation points of one pair being arranged symmetrically relative to the central point of the radiating element. The first and second transceiver modules respectively excite a first pair of excitation points arranged in a first direction of the radiating element and a second pair of excitation points arranged in a second direction of the radiating element, the first and second directions being mutually orthogonal.

Abstract: A method and apparatus (100) for vibrating an organ and/or tissue and/or region of a subject's body (202) without a mechanical transmission to characterize at least one mechanical property of the region and/or tissue and/or organ, the apparatus (100) includes: elements (114-118) for generating a pressure wave of a given frequency in a gaseous medium, and waveguide elements (106) for guiding, in a gaseous medium, the pressure wave from the generating elements (114-118) to a human or animal body (202). Wave guiding in the airways of a human or animal body and tissue displacement mapping, anisotropy, and mechanical property characterizing systems (300) and methods are also described.

Abstract: A differential amplifier including an input of a balanced type relative to a reference potential; a balanced output; first and second bipolar transistors mounted in common emitter configuration, emitters of the first and second transistors linked by two feedback impedances in series; and a perfect current generator, wherein an impedance Zg at the terminals of the current generator is connected between a common point of the two feedback impedances and the reference potential, the input is connected to a base of the first transistor, a base of the second transistor is linked to the reference potential to form, with a base of the first transistor, the unbalanced input, the balanced output is produced by collectors of the first and second transistors through an impedance matching stage of the output, a correction feedback impedance Zcorr, wherein Zcorr=2·Zg, connects the collector of the second transistor and the base of the first transistor.

Abstract: A differential amplifier including an input of a balanced type relative to a reference potential; a balanced output; first and second bipolar transistors mounted in common emitter configuration, emitters of the first and second transistors linked by two feedback impedances in series; and a perfect current generator, wherein an impedance Zg at the terminals of the current generator is connected between a common point of the two feedback impedances and the reference potential, the input is connected to a base of the first transistor, a base of the second transistor is linked to the reference potential to form, with a base of the first transistor, the unbalanced input, the balanced output is produced by collectors of the first and second transistors through an impedance matching stage of the output, a correction feedback impedance Zcorr, wherein Zcorr=2·Zg, connects the collector of the second transistor and the base of the first transistor.

Abstract: A circuit for power amplification of an input signal includes an input stage and an output stage, the said input stage including: a drive means incorporating a so-called main drive transistor, and a first so-called main input transistor able to receive the input signal, and mounted as a current mirror with the main drive transistor The first main input transistor is coupled to the output stage via a second so-called main input transistor incorporated into the input stage and controlled by the drive means, the first and second main input transistors being coupled together and with the earth according to a structure of Darlington type by way of a resonant circuit

Abstract: A signal power control device comprises two amplification channels. A first amplification channel comprises a first transconductance amplifier and a second amplification channel comprises an attenuator mounted in series with a second transconductance amplifier. Gain adjustment means allow the respective gains of the first and the second amplifier to be controlled independently, according to laws, ensuring optimum output dynamics across the entire gain range of the power control device.

Abstract: A circuit for power amplification of an input signal includes an input stage and an output stage, the said input stage including: a drive means incorporating a so-called main drive transistor, and a first so-called main input transistor able to receive the input signal, and mounted as a current mirror with the main drive transistor. The first main input transistor is coupled to the output stage via a second so-called main input transistor incorporated into the input stage and controlled by the drive means, the first and second main input transistors being coupled together and with the earth according to a structure of Darlington type by way of a resonant circuit.

Abstract: A filtering device based on an active transconductance filter includes auto-calibration means, the principle of calibration consisting in slaving the power supply current for the filter as a function of the phase shift between a second signal shifted by a first predetermined phase shift with respect to a periodic reference signal, and the output signal of the filter in response to a first signal shifted by a second predetermined phase shift with respect to the periodic reference signal, the slaving tending to minimize the phase shift between the output signal of the filter and the second signal.

Abstract: A signal power control device comprises two amplification channels. A first amplification channel comprises a first transconductance amplifier and a second amplification channel comprises an attenuator mounted in series with a second transconductance amplifier. Gain adjustment means allow the respective gains of the first and the second amplifier to be controlled independently, according to laws, ensuring optimum output dynamics across the entire gain range of the power control device.

Abstract: To monitor the operating state of a composite structure formed from at least two different materials and subject to a uniform force or load over its entire surface, the deformation at the interface between the two materials is measured. A comparison with a reference quantity of the structure, normally produced by the force applied thereto, indicates the operating state. When the composite structure forms the wall (14) of a reservoir (10), monitoring takes place in an instrumentation box (30) joined to the reservoir. When a critical threshold is exceeded, an alarm indicator (32) is triggered on the box (30).

Abstract: Apparatus provides an output signal characteristic of the geometry of a confined volume. There is a conduit with an open first end for exchanging acoustical energy with the confined volume. An electroacoustical transducer is coupled to the conduit for launching acoustical energy into the conduit towards the opening in the confined volume producing an incident wave and a reflected wave to form a wave field representative of the geometry of the confined volume. In one embodiment, the acoustical energy is launched into a sidewall of the tube. At least first and second pressure-wave-sensing transducers are mounted along the length of the conduit in spaced relationship for providing first and second transduced signals representative of the wave field at spaced locations in the conduit. A processor processes the first and second transduced signals to provide an output signal characteristic of the geometry of the confined volume. In one embodiment, the processor provides high-pass filtering of the impulse response.