Patent number: 6451789
Abstract: Compound of formula (I):
wherein:
n represents 0 or 1,
R1 represents hydrogen, arylalkyl, alkyl, acyl, alkoxycarbonyl, arylalkoxycarbonyl or trifluoroacetyl,
R2 represents alkyl,
X represents oxygen, chlorine, OR3, SR4 or NOR5,
R3 represents hydrogen , alkyl, acyl, alkoxycarbonyl or arylalkoxycarbonyl,
R4 represents hydrogen, alkyl or aryl,
R5 represents hydrogen or optionally substituted alkyl,
represents a single or double bond,
Ar represents aryl or heteroaryl, its isomers and addition salts thereof with a pharmaceutically acceptable acid, and medicinal products containing the same which are useful as facilitators of memory and cognition and antalgic agents.
Type:
Grant
Filed:
September 26, 2001
Date of Patent:
September 17, 2002
Assignee:
Les Labortoires Servier
Inventors:
Sylvain Rault, Olivier Renault, Jean Guillon, Patrick Dallemagne, Pierre Renard, Bruno Pfeiffer, Pierre Lestage, Marie-Cécile Lebrun
Patent number: 6288073
Abstract: A compound selected from those of formula (I):
in which:
X and Y represent hydrogen, halogen, hydroxy, mercapto, cyano, nitro, alkyl, alkoxy, trihaloalkyl, optionally substituted amino, methylenedioxy, or ethylenedioxy,
R1 represents hydrogen, or alkyl,
R2 represents hydrogen, hydroxy, alkyl, alkoxy, alkylcarbonyloxy, or optionally substituted ammo,
R3 and R4 represent hydrogen, or alkyl,
A represents —CH═CH—, or —CH(R5)—CH(R6)— wherein R5 and R6 are as defined in the description,
their isomers, N-oxides, and pharmaceutically-acceptable acid or base addition salts thereof,
and medicinal products containing the same which are useful in the treatment of cancer.
Type:
Grant
Filed:
June 19, 2000
Date of Patent:
September 11, 2001
Assignee:
Adir et Compagnie
Inventors:
Michel Koch, François Tillequin, Sylvie Michel, Ghanem Atassi, Alain Pierre, Bruno Pfeiffer, Pierre Renard
Patent number: 6281198
Abstract: Compound of formula (I):
wherein:
R represents:
a group of formula (i):
wherein X, Y and W are as defined in the description,
or a group of formula (ii):
—A—G (ii)
wherein:
A represents a single bond or an optionally substituted alkylene chain,
G represents a group selected from hydrogen, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, —OR2, —O—T1—NR3R4, —O—T1—NR2—T′1—NR3R4, —NR3R4, —NR2—T1—NR3R4, —NR2—T1—OR5, —NR2—T1—CO2R6, —NR2—T1—C(O)R6, —C(O)—NR3R4, —C(O)—NR2—T2, —O—C(O)T2, —O—C(S)—T2, —NR2—C(O)—T2, —NR2—C(S)—T2, —O—C(O)—O—T2, —O—C(O)—NR2—T2, —O—C(S)—O—T2, —O—C(S)—NR2—T2, —NR2—C(O)—O—T2,
Type:
Grant
Filed:
October 26, 2000
Date of Patent:
August 28, 2001
Assignee:
Adir et Compagnie
Inventors:
Claude Monneret, Emmanuel Bertounesque, Philippe Meresse, Ghanem Atassi, Alain Pierre, Bruno Pfeiffer, Pierre Renard
