Abstract: An orally disintegrating nicotine tablet for use in alleviation of nicotine craving is disclosed, the tablet comprising nicotine and a pH regulating agent, wherein the tablet is administered between the lip and gum. Also, a method for treatment of nicotine craving is disclosed.

Abstract: An orally disintegrating nicotine tablet for fast nicotine craving relief is disclosed, the tablet comprising nicotine, disintegrant, and at least one sugar alcohol, wherein the tablet comprises less than 0.4% by weight of flavor. A further orally disintegrating nicotine tablet and an oral nicotine tablet is disclosed.

Abstract: A disintegrating nicotine tablet for fast nicotine craving relief is disclosed, the tablet comprising nicotine, disintegrant, and at least one sugar alcohol, wherein the tablet comprises an amount of dissolution modifier, wherein the amount of dissolution modifier is no more than 2% by weight of the tablet.

Abstract: An oral pouched product is disclosed, the oral pouched product includes a saliva permeable pouch, a non-tobacco pouch composition, the pouch composition includes heat-treated fibers, nicotine in an amount of 0.1-5.0% by weight of the pouch compositions, water in an amount 15-65% by weight of the pouch composition, at least one sugar alcohol, and less than 0.5% preservative by weight of the pouch composition. Also, a method for manufacturing an oral pouched product is disclosed.

Abstract: A water-dissolvable nicotine tablet is disclosed, the nicotine tablet comprising at least a first compressed module and a second compressed module, wherein the first compressed module is an FDT-module and comprises nicotine, alkaline pH regulating agent, and disintegrant, and, wherein the second compressed module is a lozenge-module and comprises acidic pH regulating agent. Also, a method of manufacturing a nicotine tablet is disclosed.

Abstract: A dissolvable orally adhering nicotine tablet for sustained delivery of nicotine is disclosed, the tablet is a multilayer tablet comprising a first layer and a second layer, wherein the first layer is a mucoadhesive layer comprising a mucoadhesive, and wherein the second layer comprises at least one sugar alcohol and nicotine.

Abstract: A dissolvable orally adhering nicotine tablet for sustained delivery of nicotine is disclosed, the tablet is a multilayer tablet comprising a first layer and a second layer, wherein the first layer is a mucoadhesive layer comprising a mucoadhesive, nicotine, and at least one sugar alcohol, and wherein the second layer comprises at least one sugar alcohol.

Abstract: The invention relates an oral tablet suitable for active pharmaceutical ingredients comprising an intragranular portion and an extragranular portion. The intragranular portion comprising a plurality of granules each comprising one or more active pharmaceutical ingredients; one or more binders; and one or more excipients comprising one or more sweeteners in an amount of at least 20% by weight of the plurality of granules. The extragranular portion comprising a population of particles comprising non-directly compressible (non-DC) sweetener particles, the non-DC sweetener particles having not been granulated prior to tableting and providing the oral tablet with a plurality of discrete non-DC areas evenly distributed in the oral tablet or at least one module of the oral tablet.

Abstract: The invention relates to an oral nicotine formulation for use in the alleviation of nicotine craving, the formulation comprising a content of nicotine and a content of a pH regulating agent, wherein the formulation provides a peak saliva concentration of nicotine of more than 0.3 mg/mL and a peak saliva pH of more than 7.5 during the first 120 seconds upon oral administration.

Abstract: The invention relates to an orally disintegrating nicotine tablet for nicotine craving relief comprising a pressed powder formulation, the tablet being designed to disintegrate within a period of less than 60 seconds upon oral administration, the powder formulation comprising an amount of nicotine and a pH regulating agent.

Abstract: A nicotine pouch composition is disclosed, the pouch composition comprising free-base nicotine and having a water content of at least 15% by weight of said pouch composition. Furthermore, an oral nicotine pouch product comprising the pouch composition and a method for manufacturing the oral nicotine pouch product is disclosed.

Abstract: The invention relates to an orally disintegrating nicotine tablet for nicotine craving relief comprising a pressed powder formulation, the tablet being designed to disintegrate within a period of less than 60 seconds upon oral administration, the powder formulation comprising an amount of nicotine and a pH regulating agent.

Abstract: An oral pouched product is disclosed, the pouched product comprising a saliva permeable pouch and a pouch composition, the pouch composition comprising a powdered composition, water, and a liquid flavor composition, wherein the liquid flavor composition is added to the powdered composition after the water. A further oral pouched product and a method of manufacturing an oral pouched product is disclosed.

Abstract: A water-dissolvable compressed oral nicotine lozenge is disclosed, the oral nicotine lozenge comprising a first module and a second module, the first and the second modules being fused by compression, the first module being a lozenge module comprising at least one sugar alcohol and the second module being an FDT-module comprising at least one sugar alcohol and nicotine. Also, a method of manufacturing a water-dissolvable compressed oral nicotine lozenge is disclosed.

Abstract: A water-dissolvable nicotine tablet is disclosed, the nicotine tablet comprising at least a first compressed module and a second compressed module, wherein the first compressed module is an FDT-module and comprises nicotine, alkaline pH regulating agent, and disintegrant, and, wherein the second compressed module is a lozenge-module and comprises acidic pH regulating agent. Also, a method of manufacturing a nicotine tablet is disclosed.

Abstract: A nicotine pouch composition is disclosed, the pouch composition includes at least one sugar alcohol, at least one water-insoluble fiber, water in an amount of 8-65% by weight of the composition, and nicotine. Also, an oral pouched nicotine product and a method for manufacturing an oral pouched product is disclosed.

Abstract: The invention relates to an orally disintegrating nicotine tablet for nicotine craving relief comprising a pressed powder formulation, the tablet being designed to disintegrate within a period of less than 60 seconds upon oral administration, the powder formulation comprising an amount of nicotine and a pH regulating agent.

Abstract: A water-dissolvable nicotine tablet is disclosed, the nicotine tablet comprising at least a first compressed module and a second compressed module, wherein the first compressed module is an FDT-module and comprises nicotine, alkaline pH regulating agent, and disintegrant, and, wherein the second compressed module is a lozenge-module and comprises acidic pH regulating agent. Also, a method of manufacturing a nicotine tablet is disclosed.

Abstract: A water-dissolvable compressed oral nicotine lozenge is disclosed, the oral nicotine lozenge comprising a first module and a second module, the first and the second modules being fused by compression, the first module being a lozenge module comprising at least one sugar alcohol and the second module being an FDT-module comprising at least one sugar alcohol and nicotine. Also, a method of manufacturing a water-dissolvable compressed oral nicotine lozenge is disclosed.

Abstract: The invention relates to an orally disintegrating nicotine tablet for nicotine craving relief comprising a pressed powder formulation, the tablet being designed to disintegrate within a period of less than 60 seconds upon oral administration, the powder formulation comprising an amount of nicotine and a pH regulating agent.