Abstract: Chronic obstructive pulmonary disease (COPD) remains a major cause of morbidity and mortality worldwide. Acute exacerbation of COPD (AE-COPD) in patients are mostly due to respiratory infection and are associated with an inexorable decline in lung function, enhanced oedema as well as airway and systemic inflammation. Previous results show that treatment with anti-IL-20Rb blocking antibodies increased the bacterial clearance in control mice infected by S. pneumoniae and protected CS-exposed mice from bacterial infection, by decreasing the bacterial burden and the inflammatory infiltrate. Therefore there is an interest for generating monoclonal antibodies specific for IL-20Rb with a neutralizing activity for their use in the treatment of AE-COPD. The present invention fulfills this need by providing antibodies having specificity for IL-20Rb.

Abstract: Oil system for a turbomachine, making it possible to continue the supply of oil to the pieces of equipment of the turbomachine in case of occurrence of a fire within the turbomachine, including an oil circuit, at least one oil-consuming piece of equipment, supplied by the oil circuit, a pumping unit, including at least one speed-pilotable electrically driven pump, supplying the oil circuit, and an electronic control unit, configured to pilot the electrically driven pump, wherein the electronic control unit includes two separate logics of piloting the electrically driven pump, and wherein the electronic control unit is configured to pilot the electrically driven pump according to the first logic by default and to switch to the second logic in case of receipt of a signal representative of the presence of a fire or of an overheating.

Abstract: In ovarian carcinoma, Müllerian Inhibiting Substance (MIS) type II receptor (MISRII) and the MIS/MISRII signaling pathway are potential therapeutic targets. Conversely, the role of the three MIS type I receptors (MISRI; ALK2, ALK3 and ALK6) in this cancer needs to be clarified. Using four ovarian cancer cell lines and ovarian cancer cells isolated from patients' tumor ascites, the inventors found that ALK2 and ALK3 are the two main MISRIs involved in MIS signaling at low and high MIS concentrations, respectively. Moreover, high MIS concentrations were associated with apoptosis and decreased clonogenic survival, whereas low MIS concentrations improved cancer cell viability. Finally, the inventors showed that anti-MIS antibody B10 inhibited MIS pro-survival effect. These last results open the way to an innovative therapeutic approach to suppress MIS proliferative effect, instead of administering high doses of MIS to induce cancer cell apoptosis.

Abstract: The present invention relates to monoclonal antibodies that bind to the CD160-TM isoform. The inventors developed new monoclonal antibodies which bind to the CD160-TM isoform but dot not bind to the CD160 GPI-anchored isoform not to the CD160 soluble isoform. In particular, the antibodies of the present invention are suitable for amplifying NK cell activation and therefore cytotoxic functions NK cells.

Abstract: The present invention relates to polypeptides for preparing drug conjugates capable of promoting apoptosis in a cell expressing an orexin receptor. In particular, the present invention relates to a polypeptide comprising the amino acid sequence of formula of X20-X21-X22-X23-G-X25-L-X27-X28 wherein: —X20 represents N, D, or K, —X21 represents H, A or Q, —X22 represents A, S, T or G, —X23 represents A, T or G, —X25 represents I or L, —X27 represents T or V and, —X28 represents M, L, V, Y or I.

Abstract: The present disclosure relates to human monoclonal antibodies against orexin receptor type 1 (OX1R, hyprocretin 1) and uses thereof for the treatment of cancer. The antibodies are characterized by their CDRs: NYYMN, YISGSSRNIYYADFVKG, SNYDGMDV (Heavy chain) and AGTSSDVGGSNYVS, PGKAP, SSYTYYSTRV (Light Chain)) or the CDRS having at least 50% or 70% identity with the above listed sequences.

Abstract: A method of adjusting a fuel flow rate in a turbine engine propelling an aircraft, including: obtaining a first estimate of a flow rate of fuel injected into a combustion chamber of the turbine engine propelling an aircraft and as delivered by a fuel metering device of the turbine engine; obtaining a second estimate of the fuel flow rate, which second estimate is more accurate than the first estimate for at least one range of fuel flow rate values and being delivered by an estimator device having a flow meter; and adjusting the fuel flow rate threshold value with help of a difference evaluated between the first estimate and the second estimate, the threshold value being for use in an open loop for regulating the turbine engine.

Abstract: A method and a device for determining, in real time, the flow rate of air collected from an aircraft engine by a system for collecting air from the engine, including an acquisition device for acquiring at successive times measurements of physical quantities in respect of temperature, pressure and pressure loss, specific for the air collection system, a computing device for evaluating at each current time of the successive times a first current estimation of the flow rate of air collected from the aircraft engine on the basis of the physical quantity measurements, the acquisition device for acquiring at the current time a minimum current air flow rate data item defined on the basis of a predetermined flow rate tables, the computing device for hybridising, at the current time, the first current air flow rate estimation and the minimum current air flow rate data item to form a second current air flow rate estimation.

Abstract: Method for obtaining an super-resolution image (22) of an object (5), based upon an optical microscope (21) including a support plate (6) for bearing the object, an illumination source (1) for focusing an illumination beam (14) onto a target region of the support plate, a digital camera (9) including a matrix of sensors, comprising: capturing, by the digital camera, a first image of the target region; extracting, from the first image, a first block of pixel values provided by a sub-matrix (B0) of the matrix of sensors; displacing, by a sub-diffraction limited distance, the support plate by the displacement block along a displacement axis; capturing, by the digital camera, a second image of the target region; extracting, from the second image, a second block of pixel values provided by the sub-matrix (B0) of the matrix of sensors; storing said first and second blocks of pixel values as a first and second blocks of pixel values to be placed right next each other in the super-resolution image along the image axi

Abstract: The present disclosure provides human monoclonal antibodies and antibody-drug conjugates against AXL and their use for the treatment of cancer.

Abstract: The present invention relates to monoclonal antibodies that bind to the CD160-TM isoform. The inventors developed new monoclonal antibodies which bind to the CD160-TM isoform but dot not bind to the CD160 GPI-anchored isoform not to the CD160 soluble isoform. In particular, the antibodies of the present invention are suitable for amplifying NK cell activation and therefore cytotoxic functions NK cells.

Abstract: Disclosed are methods for diagnosing pancreatic cancer, including measuring the expression level of ASCT1 and/or ASCT2 and/or XPR1. Also disclosed is a RBD ligand coupled to at least one contrast agent, that may be used as a probe for medical imaging.

Abstract: The invention relates to a method for monitoring the operation of a fuel circuit shut-off valve comprising an LPSOV, a flow regulator, the shut-off valve, characterised in that it comprises: a step for ordering (30) the closure of the valves; a step for measuring (32) the fuel flow rate in the circuit qui carried out before the LPSOV is completely closed; and a diagnostic step (34) consisting of determining that said shut-off valve is defective if the fuel flow rate measured is not equal to zero and determining that said shut-off valve is operating correctly if the fuel flow rate measured is zero.

Abstract: The present disclosure relates to human monoclonal antibodies against orexin receptor type 1 (OX1R, hyprocretin 1) and uses thereof for the treatment of cancer. The antibodies are characterized by their CDRs: NYYMN, YISGSSRNIYYADFVKG, SNYDGMDV (Heavy chain) and AGTSSDVGGSNYVS, PGKAP, SSYTYYSTRV (Light Chain)) or the CDRS having at least 50% or 70% identity with the above listed sequences.

Abstract: The present disclosure relates to human monoclonal antibodies against orexin receptor type 1 (OX1R, hyprocretin 1) and uses thereof for the treatment of cancer. The antibodies are characterized by their CDRs: NYYMN, YISGSSRNIYYADFVKG, SNYDGMDV (Heavy chain) and AGTSSDVGGSNYVS, PGKAP, SSYTYYSTRV (Light Chain)) or the CDRS having at least 50% or 70% identity with the above listed sequences.

Abstract: Method for obtaining an super-resolution image (22) of an object (5), based upon an optical microscope (21) including a support plate (6) for bearing the object, an illumination source (1) for focusing an illumination beam (14) onto a target region of the support plate, a digital camera (9) including a matrix of sensors, comprising: capturing, by the digital camera, a first image of the target region; extracting, from the first image, a first block of pixel values provided by a sub-matrix (B0) of the matrix of sensors; displacing, by a sub-diffraction limited distance, the support plate by the displacement block along a displacement axis; capturing, by the digital camera, a second image of the target region; extracting, from the second image, a second block of pixel values provided by the sub-matrix (B0) of the matrix of sensors; storing said first and second blocks of pixel values as a first and second blocks of pixel values to be placed right next each other in the super-resolution image along the image axi

Abstract: The present disclosure provides human monoclonal antibodies and antibody-drug conjugates against AXL and their use for the treatment of cancer.

Abstract: A device for ventilating and electrically powering a computer of an engine of an aircraft, the device including a feed mechanism feeding air to a proximity of the computer and a fan connected to a drive mechanism and configured to generate a stream of air for ventilating the computer. The fan is mounted in the air feed mechanism, and the drive mechanism includes an electrical machine configured to operate as a motor for driving the fan, and as a generator for powering the computer, a rotor of the machine when operating as a generator being driven by the fan, which is itself driven by a stream of air flowing in or leaving the air feed mechanism.

Abstract: The invention is directed to a compound comprising one or more CD1d complexes in association with an antibody specific for a cell surface marker. The CD1d complexes comprise a CD1d, a ?2-microglobulin molecule, and may further comprise an antigen bound to the CD1d binding groove. The invention is further directed to methods of inhibiting or stimulating an immune response with the CD1d-antibody compounds, in particular anti-tumor and autoimmunity responses.