Patents by Inventor Bruno Silvestrini

Bruno Silvestrini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition comprising tricalcium phosphate and gelatin for use in a method for the treatment of dyspepsia and related disorders
    Patent number: 10973850
    Abstract: A pharmaceutical composition comprising tricalcium phosphate and gelatin for use in a method for the treatment of dyspepsia, acidic mouth and and/or canker sores is disclosed.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: April 13, 2021
    Assignee: Health Pharma S.p.A.
    Inventor: Bruno Silvestrini
  • PRODUCT COMPRISING HYDROLIZED COLLAGEN AND AT LEAST ONE AMORPHOUS MICRONIZED DRUG, PROCESS FOR THE PREPARATION THEREOF AND RELATED USES IN MEDICAL FIELD
    Publication number: 20180353429
    Abstract: The present invention relates to a product consisting of a conglomerate of collagen, in the form of the partly hydroyzed industrial derivative thereof called gelatine, and an amorphous micronized drug, characterized by a high bioavailability of the micronized active ingredient and a safety of use of the same deriving from the protective action of collagen against the harmful effects of contact with the active ingredient.
    Type: Application
    Filed: December 2, 2016
    Publication date: December 13, 2018
    Inventors: Bruno SILVESTRINI, Vincenzo MOLLACE
  • COMPOSITION COMPRISING TRICALCIUM PHOSPHATE AND GELATIN FOR USE IN A METHOD FOR THE TREATMENT OF DYSPEPSIA AND RELATED DISORDERS
    Publication number: 20180271905
    Abstract: A pharmaceutical composition comprising tricalcium phosphate and gelatin for use in a method for the treatment of dyspepsia, acidic mouth and and/or canker sores is disclosed.
    Type: Application
    Filed: January 8, 2016
    Publication date: September 27, 2018
    Inventor: Bruno SILVESTRINI
  • Water insoluble helychrisum extract, process for preparing the same and uses thereof
    Patent number: 8147878
    Abstract: The present invention relates to a water insoluble helychrisum extract, a process for preparing the same and its use for preparing pharmaceutical compositions for oral and/or topical administration. Furthermore, the present invention relates to the pharmaceutical compositions including said extract.
    Type: Grant
    Filed: January 12, 2007
    Date of Patent: April 3, 2012
    Assignee: Aboca S.p.A. Societa' Agricola
    Inventors: Michele Bonanomi, Bruno Silvestrini, Caterina Ghiara, Valentino Mercati
  • WATER INSOLUBLE HELYCHRISUM EXTRACT, PROCESS FOR PREPARING THE SAME AND USES THEREOF
    Publication number: 20110250301
    Abstract: The present invention relates to a water insoluble helychrisum extract, a process for preparing the same and its use for preparing pharmaceutical compositions for oral and/or topical administration. Furthermore, the present invention relates to the pharmaceutical compositions including said extract.
    Type: Application
    Filed: January 12, 2007
    Publication date: October 13, 2011
    Applicant: ABOCA S.P.A. SOCIETA' AGRICOLA
    Inventors: Michele Bonanomi, Bruno Silvestrini, Caterina Ghiara, Valentino Mercati
  • PHARMACEUTICAL COMPOSITION FOR THE SUBLINGUAL ADMINISTRATION OF VACCINES, METHOD FOR THE PREPARATION OF THE SAME AND USES THEREOF
    Publication number: 20100291115
    Abstract: The subject of the present invention is a pharmaceutical composition for the sublingual administration of vaccines, a method for its preparation and the use thereof for modulating the absorption rate and substantially improving its effectiveness and safety. Said sublingual composition is applicable both to immunizing vaccines, which are employed against infections, and to desensitising vaccines, which have allergies as therapeutic indication.
    Type: Application
    Filed: June 6, 2007
    Publication date: November 18, 2010
    Inventors: Bruno Silvestrini, Michele Bonanomi
  • WATER INSOLUBLE HELYCHRISUM EXTRACT, PROCESS FOR PREPARING THE SAME AND USES THEREOF
    Publication number: 20100227012
    Abstract: The present invention relates to a water insoluble helychrisum extract, a process for preparing the same and its use for preparing pharmaceutical compositions for oral and/or topical administration. Furthermore, the present invention relates to the pharmaceutical compositions including said extract.
    Type: Application
    Filed: December 12, 2006
    Publication date: September 9, 2010
    Applicant: ABOCA S.P.A. SOCIETA' AGRICOLA
    Inventors: Michele Bonanomi, Bruno Silvestrini, Caterina Ghiara, Valentino Mercati
  • Controlled Slow Release Formulation of Thiamine and Use Thereof in the Treatment of Pathologies Connected to Defective Process of Learning and Memorization
    Publication number: 20080311200
    Abstract: The present invention relates to thiamine controlled-release pharmaceutical compositions and their use in medicine for resolving absorption defects or deficiencies of thiamine itself from the organism. Said compositions have revealed to be useful in the treatment of cerebral pathologies connected with learning and memorizing processes. In particular, said compositions have revealed to be useful in the treatment of the Alzheimer's pathology, preferably in the forms of slight-medium intensity.
    Type: Application
    Filed: May 2, 2005
    Publication date: December 18, 2008
    Applicant: BIOPROGRESS S.P.A.
    Inventors: Michele Bonanomi, Bruno Silvestrini
  • Combined pronation and supination control plantar insert for shoes
    Publication number: 20010027616
    Abstract: A combined pronation and supination control plantar insert for shoes comprising posture control elements adapted to correct and/or modify the posture of the entire tendon, bone and muscle structure of the body, both laterally and medially and both for talipes equinus and for talipes calcaneus. The plantar insert allows to correct the main postural defects involving mastication, cervical structures, the spinal column, hips, ankles and feet.
    Type: Application
    Filed: June 13, 2001
    Publication date: October 11, 2001
    Inventors: Bruno Silvestrini, Camillo Buratto, Alberto Buratto
  • Combined pronation and supination control plantar insert for shoes
    Patent number: 6269554
    Abstract: A combined pronation and supination control plantar insert for shoes comprising posture control elements adapted to correct and/or modify the posture of the entire tendon, bone and muscle structure of the body, both laterally and medially and both for talipes equinus and for talipes calcaneus. The plantar insert allows to correct the main postural defects involving mastication, cervical structures, the spinal column, hips, ankles and feet.
    Type: Grant
    Filed: July 6, 1999
    Date of Patent: August 7, 2001
    Inventors: Bruno Silvestrini, Camillo Buratto, Alberto Buratto
  • Pharmaceutical preparations comprised of salts of hyaluronic acid with local anaesthetics
    Patent number: 6224857
    Abstract: Pharmaceutical preparations are described, comprised of salts of hyaluronic acid with a basic anesthetic containing aliphatics and/or amino groups, particularly salts with benzydamine or bupivacaine.
    Type: Grant
    Filed: July 19, 1999
    Date of Patent: May 1, 2001
    Assignee: Fidia, S.p.A.
    Inventors: Aurelio Romeo, Bruno Silvestrini, Gunter Kirschner
  • 3-substituted 1-benzyl-1H-indazole derivatives as antifertility agents
    Patent number: 6001865
    Abstract: An indazole derivative of formula (I) ##STR1## wherein R is selected from the group comprising --CONHNH.sub.2, --CONHN(CH.sub.3).sub.2 and --CH.dbd.CH--COOH,X and Y, the same or different from each other, are halogen, and salts thereof and an antifertility composition comprising the same.
    Type: Grant
    Filed: May 4, 1999
    Date of Patent: December 14, 1999
    Assignee: Angelini Pharmaceuticals Inc.
    Inventors: Bruno Silvestrini, C. Yan Cheng
  • Serum proteins related to autoimmune disease
    Patent number: 5284750
    Abstract: A method for diagnosing a patient with an autoimmune disease using monoclonal antibodies to quantitate the amount of 680 kd, 54 kd, 44 kd or 14 kd present, wherein an elevated amount of protein compared to a patient without the disease indicates the presence of autoimmune disease.
    Type: Grant
    Filed: June 24, 1991
    Date of Patent: February 8, 1994
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A
    Inventors: Bruno Silvestrini, Yan Cheng
  • Method for the treatment of autoimmune diseases
    Patent number: 5278183
    Abstract: A pharmaceutical composition for the treatment of autoimmune diseases comprising an effective amount of a compound of formulaA--CH.sub.2 --O--CRR'--COOR"' (I)whereA is the nucleus of 1-benzyl-indazol-3-yl,R and R', the same or different from each other, are H or an alkyl having from 1 to 5 carbon atoms,R"' is H or an alkyl having from 1 to 4 carbon atoms,or, when R"' is H, of a salt thereof with organic or inorganic pharmaceutically acceptable bases.
    Type: Grant
    Filed: April 14, 1992
    Date of Patent: January 11, 1994
    Assignee: Instituto Ricerca Francesco Angelini S.p.A.
    Inventor: Bruno Silvestrini
  • Serum proteins used to detect autoimmune disease
    Patent number: 5258312
    Abstract: A method for diagnosing a patient with an autoimmune disease comprising assaying a blood sample from a patient for increased levels of the carbohydrate moieties of one or more proteins, said increased level of one or more of said proteins indicating the presence of an autoimmune disease.
    Type: Grant
    Filed: June 24, 1991
    Date of Patent: November 2, 1993
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A
    Inventors: Bruno Silvestrini, Yan Cheng
  • 1-benzyl-3-hydroxymethyl-indazole compounds and derivatives
    Patent number: 5112986
    Abstract: Compounds of the formulaA--CH.sub.2 --O--CRR'--COOR'" (I)wherein A, R, R' and R'" have the meanings mentioned in the description, salts thereof with pharmaceutically acceptable bases, intermediates and processes for their preparation, and analgesic pharmaceutical compositions containing them.
    Type: Grant
    Filed: December 20, 1990
    Date of Patent: May 12, 1992
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Leandro Baiocchi, Bruno Silvestrini
  • Pharmaceutical composition for topical ophthalmic use having improved local tolerability
    Patent number: 5093348
    Abstract: The composition comprises from 0.1 to 3 moles of free lysine for each mole of an active ingredient selected from bendazac, 5-OH bendazac and the salts thereof with pharmaceutically acceptable organic and inorganic bases.
    Type: Grant
    Filed: April 18, 1990
    Date of Patent: March 3, 1992
    Assignee: Aziende Chimiche Riunite Angelini Francesco
    Inventor: Bruno Silvestrini
  • Abnormally glycosylated variants of a.sub.2 macroglobulin
    Patent number: 5047509
    Abstract: Noval abnormally glycosylated a.sub.2 -macroglobulins have been found in sera of patients suffering from autoimmune diseases. Such abnormally glycosylated materials have been isolated. The presence of these abnormally glycosylated materials in a patient's serum provides a means for diagnosing such diseases.
    Type: Grant
    Filed: February 15, 1989
    Date of Patent: September 10, 1991
    Assignee: Aziende Chimiche Riunite
    Inventors: Bruno Silvestrini, Yan Cheng
  • Method for inhibiting the development of tolerance in the analgesic treatment with morphine
    Patent number: 5041446
    Abstract: Method for inhibiting the development of tolerance in the analgesic treatment with morphine of a subject in need of said treatment, comprising administering systemically and contemporarily an effective analgesic dose of morphine and an amount of dapiprazole of from 1/4 to 1 part by weight to 1 part by weight of said analgesic dose of morphine.Pharmaceutical composition useful in the said method.
    Type: Grant
    Filed: June 6, 1989
    Date of Patent: August 20, 1991
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventor: Bruno Silvestrini
  • Ethers of 1-benzyl-3-hydroxymethyl-indazole with aliphatic 2-hydroxyacids, compositions and use
    Patent number: 4999367
    Abstract: Compunds of the formulaA--CH.sub.2 --O--CRR'--COOR'" (I)wherein A, R, R' and R'" have the meanings mentioned in the description, ts thereof with pharmaceutically acceptable bases, intermediates and processes for their preparation, and analgesic pharmaceutical compositions containing them.
    Type: Grant
    Filed: January 24, 1990
    Date of Patent: March 12, 1991
    Assignee: Aziende Chimiche Ruinite Angelini Francesco A. C. R. A. F. S. p. A.
    Inventors: Leandro Baiocchi, Bruno Silvestrini