Abstract: A reciprocating laboratory shaker with multiple force cancellations to reduce vibration and noise while permitting, typically, oscillations ranging to ¾″ peak-to-peak at speeds ranging to 6000 cpm with sample loads ranging to one pound (1 lb.) for shaking durations ranging to at least five minutes (5 min.), so as to liquify and break down cells in mixtures of biological samples and ceramic beads. The shaker has a frame; a motor with a double-ended shaft; a statically- and dynamically-balanced crankshaft at each shaft end, the two crankshafts having 180° phase difference; and two pistons, each of which is constrained for linearly reciprocating movement and connected by an associated linkage to an associated crankshaft. Engagement features on each piston engage and retain diverse jig fixtures holding samples for shaking.