Abstract: In one aspect disclosed herein are small molecule inhibitors of CD38 and their use in treating, inhibiting, decreasing, reducing, ameliorating and/or preventing graft versus host disease, ischemia reperfusion injury, graft rejection, inflammatory injury to a graft or a graft recipient. Additionally, disclosed herein are methods of inhibiting CD38 pathway and activity comprising contacting a cell expressing CD38 or administering to a subject in need of CD38 inhibition, any of the small molecule CD38 inhibitors disclosed herein.

Abstract: The network device may be configured to define or update a scene for controlling a zone in a certain area or location of a load control system. For example, the load control system may be installed in a residential home or building. At least one lighting control device that is configured to control a corresponding lighting load may be assigned to each of the one or more zones. The network device may be configured to display one or more graphical user interfaces that a user of the network device may interact with to define or update a scene. The network device may also be configured to display one or more graphical user interfaces that a user of the network device may interact with to define or update natural show functionality. After a scene and/or natural show have been configured, the may enabled or activated in response to a triggering event.

Abstract: The present disclosure relates to folder-based data organization method and system. The method may include obtaining a keyword hierarchy for a plurality of documents. The keyword hierarchy may be configured for organizing the plurality of documents and include a plurality of levels for the keyword hierarchy. The method may further include generating a folder directory in a data storage system based on the keyword hierarchy. A folder hierarchy of the folder directory reflects at least a portion of the keyword hierarchy and folders in the folder hierarchy are named based on corresponding keywords in the at least a portion of the keyword hierarchy. The method may further include determining a target folder for storing one of the documents in the folder directory based on the keyword hierarchy path associated with the document and storing the document to the target folder in the folder directory.

Abstract: Disclosed herein are methods, systems and GUIs for providing situational awareness about emergency incidents to emergency service providers (ESPs), for example, between different Public Safety Answering Points. In particular, the use of data indicators, notifications and banners can be used to provide a GUI rich in situational awareness for efficient emergency response.

Abstract: A cooling assembly includes an evaporator containing a primary cooling medium, a passive condenser, and a heat exchanger. When a secondary cooling medium is provided to the heat exchanger, the primary cooling medium in the gas phase switches from being received by the passive condenser to the heat exchanger without operating any valves located between the evaporator and the passive condenser and between the evaporator and the heat exchanger. The primary cooling medium circulates between the evaporator and the passive condenser and between the evaporator and the heat exchanger by natural circulation and gravity without a pump in the flow path of the primary cooling medium between the heat exchanger and the evaporator and between the passive condenser and the evaporator to circulate the primary cooling medium.

Abstract: The invention relates generally to antibodies, activatable antibodies, multispecific antibodies, and multispecific activatable antibodies that specifically bind to at least CD3, as well as to methods of making and using these antibodies, activatable antibodies, multispecific antibodies, and/or multispecific activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: An aqueous treating medium may include water; an acid selected from the group consisting of: HCl, HBr, HNO3, H2SO4, H2SO3, H3PO4, H3PO2, HOAc, citric acid, tartaric acid, ascorbic acid, EDTA, methanesulfonic acid, toluenesulfonic acid, and combinations thereof, wherein a concentration of the acid in the aqueous treating medium is from 0.5 M to 1.5 M; a salt, wherein a concentration of the salt in the aqueous treating medium is from greater than 0 M to 2 M; a fluoride-containing compound selected from the group consisting of: HF, NaF, NH4HF2, and combinations thereof, wherein a concentration of the fluoride-containing compound in the aqueous treating medium is from 0.026 M to 0.26 M; and silica, wherein the aqueous treating medium is saturated with silica.

Abstract: A method and system are provided in which information about a barcode on a package is received or more generally, information placed on a package by a delivery service (such as a barcode or other code) is detected. Characteristics of the information or code are extracted. The characteristics of the information or code are compared to characteristics of information or code associated with acceptable delivery services. If the characteristics of the code or information on the package correspond to characteristics of the information or code used by an acceptable delivery service, a locked area is unlocked to allow the package to be delivered. In other embodiments, other types of markings may be placed on the package by the delivery service, and the storage system may check whether those markings have, or information has, the characteristics of an acceptable delivery service.

Abstract: The present disclosure relates to folder-based data organization method and system. The method may include obtaining a keyword hierarchy for a plurality of documents. The keyword hierarchy may be configured for organizing the plurality of documents and include a plurality of levels for the keyword hierarchy. The method may further include generating a folder directory in a data storage system based on the keyword hierarchy. A folder hierarchy of the folder directory reflects at least a portion of the keyword hierarchy and folders in the folder hierarchy are named based on corresponding keywords in the at least a portion of the keyword hierarchy. The method may further include determining a target folder for storing one of the documents in the folder directory based on the keyword hierarchy path associated with the document and storing the document to the target folder in the folder directory.

Abstract: A load control system may include devices for performing communications for controlling an amount of power provided to an electrical load. The devices may include load control devices that may communicate by transmitting digital messages. A user device having an adjustable wireless communication range may be used for discovering devices, configuring devices, and/or diagnosing devices in the load control system. The user device may detect whether devices are within an established wireless communication range of one another for performing communications. The user device may detect digital messages transmitted from a device and/or digital messages received at a device to determine whether the digital messages are correctly communicated in the load control system. The user device may provide an indication to a user indicating whether a digital message is correctly transmitted or received by a device in the load control system.

Abstract: A load control system may be commissioned using beacons. The load control system may include control devices that each include a beacon transmitting circuit configured to transmit a beacon that comprises an identifier associated with the control device. A network device, such as a mobile device, may discover a control device based on the beacon received from the control device. In response to discovery of the control device, the control device may be added to a temporary group of control devices for being collectively configured and/or controlled. Control devices may be discovered based on the signal strength at which the beacons are received. The control devices may provide feedback to a user in response to confirmation messages to indicate to a user that the lighting control device has been added to the temporary group. The control devices may stop providing the feedback after they are removed from the temporary group.

Abstract: A load control system may include control devices for controlling power provided to an electrical load. The control devices may include a control-source device and a control-target device. The control-target device may control the power provided to the electrical load based on digital messages received from the control-source device. The control devices may include a load control discovery device capable of sending discovery messages configured to discover control devices within a location. The discovered control devices may be organized by signal strength and may be provided to a network device to enable association of the discovered control devices within a location. The discovery messages may be transmitted within an established discovery range. The discovery range may be adjusted to discover different control devices. Different control devices may be identified as the load control discovery device for discovering different control devices.

Abstract: A method and system are provided in which information about a barcode on a package is received or more generally, information placed on a package by a delivery service (such as a barcode or other code) is detected. Characteristics of the information or code are extracted. The characteristics of the information or code are compared to characteristics of information or code associated with acceptable delivery services. If the characteristics of the code or information on the package correspond to characteristics of the information or code used by an acceptable delivery service, a locked area is unlocked to allow the package to be delivered. In other embodiments, other types of markings may be placed on the package by the delivery service, and the storage system may check whether those markings have, or information has, the characteristics of an acceptable delivery service.

Abstract: A load control system may include control devices capable of being associated with each other at one or more locations for performing load control. Control devices may include control-source devices and/or control-target devices. A location beacon may be discovered and a unique identifier in the location beacon may be associated with a unique identifier of one or more control devices. Upon subsequent discovery of the location beacon, the associated load control devices may be controlled. The beacons may be communicated via radio frequency signals, visible light communication, and/or audio signals. The visible light communication may be used to communicate other types of information to devices in the load control system. The visible light communication may be used to identify link addresses for communicating with load control devices, load control instructions, load control configuration instructions, network communication information, and/or the like.

Abstract: A load control system may be commissioned using beacons. The load control system may include control devices that each include a beacon transmitting circuit configured to transmit a beacon that comprises an identifier associated with the control device. A network device, such as a mobile device, may discover a control device based on the beacon received from the control device. In response to discovery of the control device, the control device may be added to a temporary group of control devices for being collectively configured and/or controlled. Control devices may be discovered based on the signal strength at which the beacons are received. The control devices may provide feedback to a user in response to confirmation messages to indicate to a user that the lighting control device has been added to the temporary group. The control devices may stop providing the feedback after they are removed from the temporary group.

Abstract: A multimode clutch assembly is positioned in a powertrain of a rotorcraft. The clutch assembly includes a freewheeling unit having a driving mode in which torque applied to the input race is transferred to the output race and an overrunning mode in which torque applied to the output race is not transferred to the input race. A bypass assembly has an engaged position that couples the input and output races of the freewheeling unit. An actuator assembly shifts the bypass assembly between engaged and disengaged positions. An engagement status sensor is configured to determine the engagement status of the bypass assembly. In the disengaged position, the overrunning mode of the freewheeling unit is enabled such that the clutch assembly is configured for unidirectional torque transfer. In the engaged position, the overrunning mode of the freewheeling unit is disabled such that the clutch assembly is configured for bidirectional torque transfer.

Abstract: A load control system may include control devices for controlling power provided to an electrical load. The control devices may include a control-source device and a control-target device. The control-target device may control the power provided to the electrical load based on digital messages received from the control-source device. The control devices may include a load control discovery device capable of sending discovery messages configured to discover control devices within a location. The discovered control devices may be organized by signal strength and may be provided to a network device to enable association of the discovered control devices within a location. The discovery messages may be transmitted within an established discovery range. The discovery range may be adjusted to discover different control devices. Different control devices may be identified as the load control discovery device for discovering different control devices.

Abstract: A load control system may include devices for performing communications for controlling an amount of power provided to an electrical load. The devices may include load control devices that may communicate by transmitting digital messages. A user device having an adjustable wireless communication range may be used for discovering devices, configuring devices, and/or diagnosing devices in the load control system. The user device may detect whether devices are within an established wireless communication range of one another for performing communications. The user device may detect digital messages transmitted from a device and/or digital messages received at a device to determine whether the digital messages are correctly communicated in the load control system. The user device may provide an indication to a user indicating whether a digital message is correctly transmitted or received by a device in the load control system.

Abstract: A load control system may include control devices capable of being associated with each other at one or more locations for performing load control. Control devices may include control-source devices and/or control-target devices. A location beacon may be discovered and a unique identifier in the location beacon may be associated with a unique identifier of one or more control devices. Upon subsequent discovery of the location beacon, the associated load control devices may be controlled. The beacons may be communicated via radio frequency signals, visible light communication, and/or audio signals. The visible light communication may be used to communicate other types of information to devices in the load control system. The visible light communication may be used to identify link addresses for communicating with load control devices, load control instructions, load control configuration instructions, network communication information, and/or the like.

Abstract: Automated fiber placement (AFP) cutter blade assemblies, AFP cutter systems including the same, and associated methods. An AFP cutter blade assembly includes a blade base and a reversible blade insert configured to be coupled to the blade base in either of a first cutter blade configuration, in which a first cutting edge is an active cutting edge, and a second cutter blade configuration, in which a second cutting edge is the active cutting edge. In examples, an AFP cutter system includes a plurality of AFP cutter blade assemblies in combination with an actuator assembly. In examples, a method of reconfiguring a reversible blade insert of an AFP cutter blade assembly includes uncoupling the reversible blade insert from a blade base, rotating the reversible blade insert relative to the blade base, and operatively coupling the reversible blade insert to the blade base in a different configuration.