Patents by Inventor Bryan Allen CLARK

Bryan Allen CLARK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10770182
    Abstract: Embodiments herein include medical systems, devices, and methods for assessing the health status of a patient. In an embodiment, a method includes evaluating the presence of volatile organic compounds in a breath or gas sample of the patient with a plurality of graphene sensors to generate volatile organic compound data, wherein the plurality of graphene sensors include sensors that are specific for different volatile organic compounds. The method can further include collecting data regarding the patient's sympathetic nervous activity. The method can further include combining the volatile organic compound data with the collected data regarding the patient's sympathetic nervous activity to form a combined data set. The method can further include matching the combined data set against one or more data patterns to find the best match, the best match indicating the health status of the patient. Other embodiments are also included herein.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: September 8, 2020
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Gregory J. Sherwood, Kyle Harish Srivastava, Bryan Allen Clark, Justin Theodore Nelson, Carl Walter Bauer
  • Patent number: 10750994
    Abstract: An example of a system for managing pain may include a pain monitoring circuit, a pain relief device, and a control circuit. The pain monitoring circuit may include a parameter analyzer and a pain score generator. The parameter analyzer may be configured to receive and analyze at least two parameters selected from a physiological parameter indicative of a physiological function or state of a patient, a functional parameter indicative of a physical activity or state of the patient, or a patient parameter including subjective information provided by the patient. The pain score generator may be configured to compute a composite pain score using an outcome of the analysis. The composite pain score may indicate a degree of the pain. The pain relief device may be configured to deliver a pain-relief therapy. The control circuit may be configured to control the delivery of the pain-relief therapy using the composite pain score.
    Type: Grant
    Filed: August 28, 2017
    Date of Patent: August 25, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Elizabeth M. Annoni, Bryan Allen Clark, Pramodsingh Hirasingh Thakur, Jianwen Gu, James John Kleinedler, Kyle Harish Srivastava, David J. Ternes, David L. Perschbacher, Rosana Esteller
  • Publication number: 20200253661
    Abstract: The present disclosure relates to methods, devices, kits and systems for enhancing the efficacy and longevity of denervation procedures.
    Type: Application
    Filed: April 30, 2020
    Publication date: August 13, 2020
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Bryan Allen Clark, JR., Akshay Ashok Gupte, Bryce Calvin Beverlin, II, David Ernest Wechter, Kate Taylor
  • Patent number: 10729905
    Abstract: This document discusses, among other things, systems and methods for managing pain of a subject. A system may include one or more sensors configured to sense a signal indicative of muscle electrical or mechanical activity at a specific body location. The muscle electrical or mechanical activity signal may include an electromyography or a mechanical contraction signal. A pain analyzer circuit may extract from the sensed signal one or more signal metrics indicative of muscle tension, and generate a pain score using the signal metrics. The pain score may be output to a user or a process. The system may include a neurostimulator that can adaptively control the delivery of pain therapy by automatically adjusting stimulation parameters based on the pain score.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: August 4, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Elizabeth Mary Annoni, Jianwen Gu, Pramodsingh Hirasingh Thakur, Bryan Allen Clark, Kyle Harish Srivastava
  • Publication number: 20200238087
    Abstract: This document discusses, among other things, systems and methods for managing pain of a subject. A system includes one or more physiological sensors configured to sense a physiological signal indicative of patient brain activity. The physiological signals may include an electroencephalography signal, a magnetoencephalography signal, or a brain-evoked potential. The system may extract from the brain activity signal one or more signal metrics indicative of strength or pattern of brain electromagnetic activity associated with pain, and generate a pain score using the one or more signal metrics. The pain score can be output to a patient or a process. The system may select an electrode configuration for pain-relief electrostimulation based on the pain score, and deliver a closed-loop pain therapy according to the selected electrode configuration.
    Type: Application
    Filed: April 14, 2020
    Publication date: July 30, 2020
    Inventors: Elizabeth Mary Annoni, Jianwen Gu, Rosana Esteller, Bryan Allen Clark, Pramodsingh Hirasingh Thakur, Kyle Harish Srivastava
  • Patent number: 10716620
    Abstract: The present disclosure relates to the field of tissue mapping and ablation. Specifically, the present disclosure relates to expandable medical devices for identifying and treating local anatomical abnormalities within a body lumen. More specifically, the present disclosure relates to systems and methods of focal treatment for overactive bladders.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: July 21, 2020
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Sandra Nagale, Mark W. Boden, Bryan Allen Clark, Shibaji Shome, Amedeo J. Chiavetta
  • Publication number: 20200214624
    Abstract: This document discusses, among other things, systems and methods for managing pain of a subject. A system may include a motion sensor configured to sense at least one functional signal indicative a physical state of the subject. The at least one functional signal may include at least one motor activity signal or at least one sleep state signal. A pain analyzer circuit may extract, from the functional signal, signal metrics indicative of subject motor control or kinetics, and generate a pain score using the signal metrics. The pain score may be output to a user or a process. The system may additionally include an electrostimulator to generate and deliver a closed-loop pain therapy according to the pain score.
    Type: Application
    Filed: March 17, 2020
    Publication date: July 9, 2020
    Inventors: Bryan Allen CLark, Elizabeth Mary Annoni, Jianwen Gu, Kyle Harish Srivastava, Pramodsingh Hirasingh Thakur, James John Kleinedler, David J. Ternes
  • Publication number: 20200214623
    Abstract: An example of a system for providing a patient with pain management includes a pain monitoring circuit. The pain monitoring circuit may include parameter analyzer circuitry and pain score generator circuitry. The parameter analyzer circuitry may be configured to receive and analyze one or more timing parameters and one or more baroreflex parameters allowing for determination of baroreflex sensitivity (BRS) of the patient. The one or more timing parameters are indicative of time intervals during which values of the one or more baroreflex parameters are used to determine the BRS. The pain score generator circuitry may be configured to compute a pain score using an outcome of the analysis. The pain score is a function of the BRS during the time intervals and indicative of a degree of pain of the patient.
    Type: Application
    Filed: March 16, 2020
    Publication date: July 9, 2020
    Inventors: Elizabeth Mary Annoni, Pramodsingh Hirasingh Thakur, Bryan Allen Clark, Kyle Harish Srivastava, Jianwen Gu, James John Kleinedler, David J. Ternes, David L. Perschbacher
  • Publication number: 20200215266
    Abstract: A system may include an input device configured to receive a signal indicative of elevated glucose in a patient, and an electrical stimulator configured to electrically stimulate at least one skeletal muscle. The system may further include a controller operably connected to the electrical stimulator. The controller may be configured for delivering a glucose therapy in response to the signal by controlling the electrical stimulator. The system may be configured to deliver the therapy in combination with other glucose therapies, and the therapy may be titrated based on a sensed parameter or patient feedback.
    Type: Application
    Filed: January 2, 2020
    Publication date: July 9, 2020
    Inventors: Vijay Koya, Bryan Allen Clark, Keith R. Maile, Michael J. Kane, Jeffrey E. Stahmann, Elizabeth Mary Annoni
  • Publication number: 20200188673
    Abstract: Systems and methods for managing pain in patient are described. A system may include sensors configured to sense physiological or functional signals, and a pain analyzer to generate signal metrics from the physiological or functional signals. The pain analyzer also generates weight factors corresponding to the signal metrics. The weight factors may indicate the signal metrics reliability in representing an intensity of the pain. The pain analyzer generates a pain score using a plurality of signal metrics and a plurality of weight factors. The pain score may be output to a user or a process. The system may additionally include an electrostimulator to generate and deliver closed-loop pain therapy according to the pain score.
    Type: Application
    Filed: February 25, 2020
    Publication date: June 18, 2020
    Inventors: Pramodsingh Hirasingh Thakur, Jianwen Gu, Bryan Allen Clark, David J. Ternes, David L. Perschbacher, James John Kleinedler, Elizabeth Mary Annoni
  • Patent number: 10675469
    Abstract: This document discusses, among other things, systems and methods for managing pain of a subject. A system includes one or more physiological sensors configured to sense a physiological signal indicative of patient brain activity. The physiological signals may include an electroencephalography signal, a magnetoencephalography signal, or a brain-evoked potential. The system may extract from the brain activity signal one or more signal metrics indicative of strength or pattern of brain electromagnetic activity associated with pain, and generate a pain score using the one or more signal metrics. The pain score can be output to a patient or a process. The system may select an electrode configuration for pain-relief electrostimulation based on the pain score, and deliver a closed-loop pain therapy according to the selected electrode configuration.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: June 9, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Elizabeth Mary Annoni, Jianwen Gu, Rosana Esteller, Bryan Allen Clark, Pramodsingh Hirasingh Thakur, Kyle Harish Srivastava
  • Patent number: 10675085
    Abstract: The present disclosure relates to methods, devices, kits and systems for enhancing the efficacy and longevity of denervation procedures.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: June 9, 2020
    Assignees: Boston Scientific Scimed, Inc., Regents of the University of Minnesota
    Inventors: Bryan Allen Clark, Akshay Ashok Gupte, Bryce Calvin Beverlin, II, David Ernest Wechter, Kate Taylor
  • Patent number: 10667747
    Abstract: An example of a system for providing a patient with pain management includes a pain monitoring circuit. The pain monitoring circuit may include parameter analyzer circuitry and pain score generator circuitry. The parameter analyzer circuitry may be configured to receive and analyze one or more timing parameters and one or more baroreflex parameters allowing for determination of baroreflex sensitivity (BRS) of the patient. The one or more timing parameters are indicative of time intervals during which values of the one or more baroreflex parameters are used to determine the BRS. The pain score generator circuitry may be configured to compute a pain score using an outcome of the analysis. The pain score is a function of the BRS during the time intervals and indicative of a degree of pain of the patient.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: June 2, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Elizabeth Mary Annoni, Pramodsingh Hirasingh Thakur, Bryan Allen Clark, Kyle Harish Srivastava, Jianwen Gu, James John Kleinedler, David J. Ternes, David L. Perschbacher
  • Patent number: 10639477
    Abstract: An example of a system may include an electrode and a pulse generation system. The electrode may be configured to be implanted near a neural target that innervates airways. The pulse generation system may be configured to be operably connected to the electrode to deliver depletion block stimulation through the electrode to alleviate symptoms of pulmonary disease. The pulse generation system and the electrode may be configured to cooperate to capture axons in the neural target. The depletion block stimulation may include a series of pulses at a depletion pulse frequency.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: May 5, 2020
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Manfred Franke, Bryan Allen Clark, Aiden Flanagan, Juan Gabriel Hincapie Ordonez, David J. Ternes
  • Patent number: 10631776
    Abstract: This document discusses, among other things, systems and methods for managing pain of a subject. A system may include a sensor circuit configured to sense a respiration signal and a heart rate signal. A pain analyzer circuit may determine respiratory cycles and respiratory phases in a respiratory cycle, and generate one or more signal metrics indicative of respiration-mediated heart rate variation. The pain analyzer may generate a pain score using the signal metrics indicative of respiration-mediated heart rate variation. The pain score may be output to a user or a process. The system may include an electrostimulator to generate and deliver closed-loop pain therapy according to the pain score.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: April 28, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Elizabeth Mary Annoni, Bryan Allen Clark, Pramodsingh Hirasingh Thakur, Kyle Harish Srivastava
  • Patent number: 10631777
    Abstract: This document discusses, among other things, systems and methods for managing pain of a subject. A system may include a motion sensor configured to sense at least one functional signal indicative a physical state of the subject. The at least one functional signal may include at least one motor activity signal or at least one sleep state signal. A pain analyzer circuit may extract, from the functional signal, signal metrics indicative of subject motor control or kinetics, and generate a pain score using the signal metrics. The pain score may be output to a user or a process. The system may additionally include an electrostimulator to generate and deliver a closed-loop pain therapy according to the pain score.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: April 28, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Bryan Allen Clark, Elizabeth Mary Annoni, Jianwen Gu, Kyle Harish Srivastava, Pramodsingh Hirasingh Thakur, James John Kleinedler, David J. Ternes
  • Patent number: 10610688
    Abstract: Systems and methods for managing pain in patient are described. A system may include sensors configured to sense physiological or functional signals, and a pain analyzer to generate signal metrics from the physiological or functional signals. The pain analyzer also generates weight factors corresponding to the signal metrics. The weight factors may indicate the signal metrics reliability in representing an intensity of the pain. The pain analyzer generates a pain score using a plurality of signal metrics and a plurality of weight factors. The pain score may be output to a user or a process. The system may additionally include an electrostimulator to generate and deliver closed-loop pain therapy according to the pain score.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: April 7, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Pramodsingh Hirasingh Thakur, Jianwen Gu, Bryan Allen Clark, David J. Ternes, David L. Perschbacher, James John Kleinedler, Elizabeth M. Annoni
  • Patent number: 10583295
    Abstract: An example of a system may include a lead including a distal electrode portion. The distal electrode portion may be configured to at least partially encircle a sympathetic chain in a lumbar region or thoracic region. The distal electrode portion may include at least one electrode oriented toward the sympathetic chain when the distal electrode portion at least partially encircles the sympathetic chain. The distal portion may include at least one anchoring site configured for use to mechanically secure the distal electrode portion to tissue proximate to the sympathetic chain. The lead may have a strain relief proximate to the distal electrode portion.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: March 10, 2020
    Assignees: Regents of the University of Minnesota, Boston Scientific Scimed, Inc.
    Inventors: Akshay Ashok Gupte, Bryan Allen Clark, Bryce Calvin Beverlin, II, David Ernest Wechter
  • Publication number: 20200069366
    Abstract: A system and method for denervation where a catheter includes a radially expandable member, the radially expandable member including an exterior surface, a plurality of electrodes on the exterior surface configured for delivery of energy during a denervation procedure in a vessel, and a chemical agent coating on the exterior surface, wherein the chemical agent inhibits or prevents nerve regeneration. The radially expandable member is configured to have a first unexpanded configuration and a second expanded configuration, and is configured to bring the exterior surface in contact with a wall of a vessel when it is in the expanded configuration.
    Type: Application
    Filed: August 28, 2019
    Publication date: March 5, 2020
    Inventors: Bryan Allen Clark, Vijay Koya, Elizabeth M. Annoni, Hong Cao
  • Patent number: 10576285
    Abstract: An example of a system for modulating blood pressure may include a blood pressure monitoring circuit, a blood pressure modulation device, and a control circuit. The blood pressure monitoring circuit may be configured to sense signals and generate one or more blood pressure parameters indicative of the blood pressure and/or a vascular resistance and one or more activity parameters indicative of an activity level and/or a postural change using the sensed signals. The blood pressure modulation device may be configured to deliver a therapy modulating the blood pressure. The control circuit may be configured to control the therapy using therapy parameters, receive the one or more blood pressure parameters and the one or more activity parameters, analyze changes in the one or more blood pressure parameters that are correlated to changes in the one or more activity parameters, and adjust the therapy parameters using an outcome of the analysis.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: March 3, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Elizabeth Mary Annoni, Kyle Harish Srivastava, Craig Stolen, Pramodsingh Hirasingh Thakur, Bradley Lawrence Hershey, Stephen B. Ruble, William Conrad Stoffregen, Bryan Allen Clark