Abstract: The present disclosure provides a method of treating peri-orbital fullness in a subject upon determining if the subject exhibits pseudoherniation of one or more upper eyelid fat pads and/or one or more lower eyelid fat pads, determining if the subject exhibits one or more conditions selected from the group consisting of: edema of the fat pad, edema along the soft tissue of the upper and/or lower eyelids, malar mounds due to edema, malar edema, and mild festoons aggravated by edema, and scoring the peri-orbital fullness from both determinations.

Abstract: The present disclosure provides a method of treating peri-orbital puffiness due to peri-orbital edema in a subject in need thereof by administering a composition that comprises a protein having hyaluronidase activity fused to a targeting moiety to the peri-orbital region of the subject. Also provided is a method of assessing peri-orbital puffiness in a subject by determining if the subject exhibits pseudoherniation of one or more upper eyelid fat pads and one or more lower eyelid fat pads; determining if the subject exhibits edema in one or more of the upper eyelid fat pads and the one or more of the lower eyelid fat pads; determining if the subject exhibits edema in the peri-orbital tissue; and scoring the peri-orbital puffiness due to peri-orbital edema from each of the prior three determinations.

Abstract: An electronic computer system classifies an anatomical target by obtaining a series of input images of the target; detecting a difference in a characteristic of the anatomical target across the series of input images; comparing, using a pattern recognition process, the difference in the characteristic across the series of input images to respective differences in characteristics across respective series of reference images; and classifying the anatomical target based on similarities with reference images analyzed during the comparing.

Abstract: An electronic computer system creates a treatment plan and provides safe and accurate treatment recommendations by obtaining an input image of a face; comparing, using a pattern recognition process, one or more aspects of the input image to corresponding aspects of a plurality of reference images; obtaining, based on a result of the comparing, supplemental information associated with one or more additional characteristics of the face; and creating a treatment plan based on the input image and the additional characteristic.

Abstract: The present disclosure provides a method of treating a respiratory disease or disorder in a subject in need thereof, the method comprising: administering a protein having hyaluronidase activity and/or 4-methylumbelliferone (4-MU) to a lung of the subject including, for example, in an aerosolized formulation.

Abstract: A surgical drain including an introducer having a central axis, a proximal end, and a distal end. The proximal end disposed along the central axis and configured to couple to a drain. The distal end having a blunt distal tip and the introducer at least partially tapering from the proximal end to the distal end, wherein the introducer has a length of 30 cm or greater.

Abstract: The present disclosure provides a method of treating fibrosis in a subject in need thereof by administering a composition that comprises a protein having hyaluronidase activity to a region of the subject having fibrosis. Also provided are methods of reducing an amount or severity of fibrosis in a subject in need thereof comprising administering a composition that comprises a protein having hyaluronidase activity to a region of the subject having fibrosis, wherein the administration results in a reduction in a grade of severity of the fibrosis.

Abstract: The present disclosure provides a method for treating a subject with periorbital puffiness by determining if the periorbital puffiness is due to edema or a structural change and administering a protein having hyaluronidase activity to the periorbital region of the subject if the periorbital puffiness is due to edema. Also provided are methods for determining if periorbital puffiness is due to edema or a structural change in a subject in need thereof by administering a composition that comprises a protein having hyaluronidase activity to the periorbital region of the subject, assessing the periorbital region at a predetermined amount of time after the administration of the composition, and then determining whether there is an improvement in the periorbital puffiness.

Abstract: The present disclosure generally relates to methods and compositions comprising a protein having hyaluronidase activity to diagnose the etiology of, minimize, and treat peri-orbital hollowness with or without associated thyroid disease and to treat tear trough deformity.

Abstract: The present disclosure provides a method of treating cellulite in a subject in need thereof by administering a composition that comprises a protein having hyaluronidase activity to a region of skin having cellulite on the subject. Also provided are methods of reducing the appearance of cellulite in a subject in need thereof comprising administering a composition that comprises a protein having hyaluronidase activity to a region of skin having cellulite on the subject, wherein the administration results in a reduction in a grade of severity of the cellulite.

Abstract: The present disclosure provides a method of treating edema in a subject in need thereof, comprising the step of administering a composition that comprises a protein having hyaluronidase activity to a region of the subject having edema.

Abstract: The present disclosure provides methods for determining an etiology of upper and/or lower eyelid puffiness by examining a subject with squinted eyes; and determining if upper and/or lower eyelid puffiness does not improve, improves, partially improves, or worsens, wherein the etiology of the upper and/or lower eyelid puffiness is diagnosed to be anterior to the orbicularis oculi muscle if the puffiness does not improve, wherein the etiology of the upper and/or lower eyelid puffiness is determined to be posterior to the orbicularis oculi muscle if the puffiness improves, wherein the etiology of the upper and/or lower eyelid puffiness is determined to be anterior and posterior to the orbicularis oculi muscle if the puffiness partially improves, or wherein the puffiness is determined to be secondary to hypertrophy of the orbicularis muscle or if the puffiness worsens.

Abstract: An electronic computing system creates a treatment plan and provides safe and accurate treatment recommendations by obtaining an input image of a face; comparing, using a pattern recognition process, one or more aspects of the input image to corresponding aspects of a plurality of reference images; obtaining, based on a result of the comparing, supplemental information associated with one or more additional characteristics of the face; and creating a treatment plan based on the input image and the additional characteristic.

Abstract: An electronic computing system creates a treatment plan and provides safe and accurate treatment recommendations by obtaining an input image of a face; comparing, using a pattern recognition process, one or more aspects of the input image to corresponding aspects of a plurality of reference images; obtaining, based on a result of the comparing, supplemental information associated with one or more additional characteristics of the face; and creating a treatment plan based on the input image and the additional characteristic.

Abstract: The present disclosure provides a method of assessing periorbital puffiness in a subject by determining if the subject exhibits pseudoherniation of one or more upper eyelid fat pads and/or one or more of the lower eyelid fat pads, determining if the subject exhibits one or more conditions selected from the group consisting of: edema of the fat pad, edema along the soft tissue of the upper and/or lower eyelids, malar mounds due to edema, malar edema, and mild festoons aggravated by edema, and scoring the periorbital puffiness from both determinations.

Abstract: The present disclosure provides methods for determining an etiology of upper and/or lower eyelid puffiness by examining a subject with squinted eyes; and determining if upper and/or lower eyelid puffiness does not improve, improves, partially improves, or worsens, wherein the etiology of the upper and/or lower eyelid puffiness is diagnosed to be anterior to the orbicularis oculi muscle if the puffiness does not improve, wherein the etiology of the upper and/or lower eyelid puffiness is determined to be posterior to the orbicularis oculi muscle if the puffiness improves, wherein the etiology of the upper and/or lower eyelid puffiness is determined to be anterior and posterior to the orbicularis oculi muscle if the puffiness partially improves, or wherein the puffiness is determined to be secondary to hypertrophy of the orbicularis muscle or if the puffiness worsens.

Abstract: The present disclosure provides a method of assessing periorbital puffiness in a subject by determining if the subject exhibits pseudoherniation of one or more upper eyelid fat pads and/or one or more of the lower eyelid fat pads, determining if the subject exhibits one or more conditions selected from the group consisting of: edema of the fat pad, edema along the soft tissue of the upper and/or lower eyelids, malar mounds due to edema, malar edema, and mild festoons aggravated by edema, and scoring the periorbital puffiness from both determinations.

Abstract: The present disclosure provides a method for treating a subject with periorbital puffiness by determining if the periorbital puffiness is due to edema or a structural change and administering a protein having hyaluronidase activity to the periorbital region of the subject if the periorbital puffiness is due to edema. Also provided are methods for determining if periorbital puffiness is due to edema or a structural change in a subject in need thereof by administering a composition that comprises a protein having hyaluronidase activity to the periorbital region of the subject, assessing the periorbital region at a predetermined amount of time after the administration of the composition, and then determining whether there is an improvement in the periorbital puffiness.

Abstract: The present disclosure provides a method of treating periorbital puffiness in a subject in need thereof by administering a composition that comprises a protein having hyaluronidase activity to a periorbital region of the subject. Also provided is a method of assessing periorbital puffiness in a subject by determining if the subject exhibits pseudoherniation of one or more upper eyelid fat pads and one or more lower eyelid fat pads; determining if the subject exhibits edema in one or more of the upper eyelid fat pads and the one or more of the lower eyelid fat pads; determining if the subject exhibits edema in the periorbital tissue; and scoring the periorbital puffiness due to periorbital edema from each of the prior three determinations.