Abstract: A slider window assembly for a motor vehicle includes a fixed panel formed of a single pane encircling an opening formed therein, a slider panel movable along a horizontal axis between closed and open positions, an injection-molded plastic slider frame adhesively bonded to the fixed panel, and at least one seal member forming a seal between the slider frame and the slider panel. The slider frame includes a sealing frame extending entirely about the opening, an upper run located above the opening and receiving the slider panel, and a lower run located below the opening and receiving the slider panel. There is preferably a substantially continuous adhesive bond between the slider frame and the fixed panel that entirely encircles the opening.