Patents by Inventor Bryan F. Cox

Bryan F. Cox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF TREATING IMMUNE DYSFUNCTION IN LIVER CANCER WITH TOLL-LIKE RECEPTOR AGONISTS
    Publication number: 20250101438
    Abstract: Methods for treating liver immune dysfunction in a subject are provided. The liver immune dysfunction may be induced by at least one tumor resulting from metastasis in the liver or at least one primary liver cancer. An exemplary method comprises administering to the subject a toll-like receptor 9 (TLR9) agonist, for example, a TLR 9 agonist having the structure: 5?-TCG AAC GTT CGA ACG TTC GAA CGT TCG AAT-3. The TLR9 agonist is administered to the liver, for example, the TLR9 agonist may be administered to the liver using a locoregional therapy through the vasculature.
    Type: Application
    Filed: January 20, 2023
    Publication date: March 27, 2025
    Applicant: TriSalus Life Sciences, Inc.
    Inventors: Steven C. Katz, Bryan F. Cox, Chandra C. Ghosh, Prajna Guha, Jason LaPorte
  • CANCER THERAPY USING CHECKPOINT INHIBITORS
    Publication number: 20240218068
    Abstract: Embodiments of the present invention provide for methods of treating cancer and methods of delivering checkpoint inhibitors to solid tumors in the liver using a locoregional therapy through the vasculature. In one aspect, the present invention relates to a method of treating metastases of colorectal cancer of the liver comprising administering of checkpoint inhibitors to the liver. In another aspect, the present invention relates to a method of treating pancreatic cancer comprising administering checkpoint inhibitors to the pancreas.
    Type: Application
    Filed: April 29, 2022
    Publication date: July 4, 2024
    Applicant: TriSalus Life Sciences, Inc.
    Inventors: Steven C. Katz, Bryan F Cox
  • CANCER THERAPY USING TOLL-LIKE RECEPTOR AGONISTS
    Publication number: 20240180952
    Abstract: Embodiments of the present invention provide for methods of treating cancer and methods of delivering toll-like receptor (TLR) agonists to solid tumors in the liver using a locoregional therapy through the vasculature. In one aspect, the present invention relates to a method of treating primary liver cancers such as hepatocellular carcinoma (HCC) and intra-hepatic cholangiocarcinoma (ICC) comprising administering TLR9 agonists to the liver.
    Type: Application
    Filed: March 31, 2022
    Publication date: June 6, 2024
    Applicant: TriSalus Life Sciences, Inc.
    Inventors: Steven C. Katz, Bryan F. Cox, David Benjamin Jaroch
  • CANCER THERAPY USING TOLL-LIKE RECEPTOR AGONISTS
    Publication number: 20230374523
    Abstract: Embodiments of the present invention provide for methods of treating cancer and methods of delivering toll-like receptor (TLR) agonists to solid tumors in the pancreas using a locoregional therapy through the vasculature. In one aspect, the present invention relates to a method of treating pancreatic cancer comprising administering TLR agonists to the pancreas.
    Type: Application
    Filed: September 21, 2021
    Publication date: November 23, 2023
    Applicant: TriSalus Life Sciences, Inc.
    Inventors: Steven C. Katz, Bryan F. Cox, David Benjamin Jaroch
  • CANCER THERAPY USING TOLL-LIKE RECEPTOR AGONISTS
    Publication number: 20230364125
    Abstract: Embodiments of the present invention provide for methods of treating cancer and methods of delivering toll-like receptor (TLR) agonists to solid tumors in the liver using a locoregional therapy through the vasculature. In one aspect, the present invention relates to a method of treating metastases of uveal melanoma of the liver comprising administering TLR9 agonists to the liver.
    Type: Application
    Filed: September 21, 2021
    Publication date: November 16, 2023
    Applicant: TriSalus Life Sciences, Inc.
    Inventors: Steven C. Katz, Bryan F. Cox, David Benjamin Jaroch
  • RAPAMYCIN ANALOG FOR PREVENTION AND/OR TREATMENT OF NEURODEGNERATIVE CONDITIONS
    Publication number: 20210369684
    Abstract: This disclosure relates to a novel rapamycin analogue of Formula I or Formula II, mixtures, methods for its production, and its use in preventing and/or treating a neurodegenerative condition.
    Type: Application
    Filed: February 8, 2019
    Publication date: December 2, 2021
    Applicant: Torcept Therapeutics, Inc.
    Inventors: Timothy S POWERS, Bryan F COX, Richard B MARSHAK
  • RAPAMYCIN ANALOG FOR PREVENTION AND/OR TREATMENT OF NEURODEGNERATIVE CONDITIONS
    Publication number: 20210030726
    Abstract: The present invention relates to a novel rapamycin analogue of Formula (I), mixtures, methods for its production, and its use in preventing and/or treating a neurodegenerative condition.
    Type: Application
    Filed: February 8, 2019
    Publication date: February 4, 2021
    Applicant: Torcept Therapeutics, Inc.
    Inventors: Timothy S Powers, Bryan F Cox, Richard B Marshak
  • RAPAMYCIN ANALOG FOR PREVENTION AND/OR TREATMENT OF CANCER
    Publication number: 20210024542
    Abstract: The present invention relates to a novel rapamycin analogue, mixtures, methods for its production, and its use in cancer therapy (e.g., prevention and/or treatment).
    Type: Application
    Filed: February 8, 2019
    Publication date: January 28, 2021
    Applicant: Torcept Therapeutics, Inc.
    Inventors: Timothy S Powers, Bryan F Cox, Richard B Marshak
  • Rapamycin Analog
    Publication number: 20200131196
    Abstract: The present invention relates to a novel rapamycin analogue (e.g., of Formula I or Formula II), mixtures, methods for its production, and its use in cancer therapy (e.g., prevention and/or treatment).
    Type: Application
    Filed: February 9, 2018
    Publication date: April 30, 2020
    Applicant: Mount Tam Therapeutics, Inc.
    Inventors: Timothy S. Powers, Bryan F. Cox, Richard B. Marshak