Abstract: The present disclosure provides the methods for making 4-[4-cyano-2-({[(2?R,4S)-6-(isopropylcarbamoyl)-2,3-dihydrospiro[chromene-4,1?-cyclopropan]-2?-yl]carbonyl}amino)phenyl]butanoic acid. The present disclosure also generally relates to intermediates useful in the said methods.

Abstract: A wearable device for providing ultrasound guidance feedback may include a housing that has a plurality of haptic actuators, and an opening extending along an axis through the housing. The opening may fit about a body part of an operator of an ultrasound probe, and the haptic actuators may pulse in an actuation pattern indicative of one or more suggested movements of the ultrasound probe to position the ultrasound probe in a desired position to acquire imaging data of a region of interest of a patient.

Abstract: The invention relates to a process for the optical testing of a surface of an object, particularly a compact disc, in which the surface is illuminated by at least one light source and the light reflected and/or scattered by the surface is projected onto at least one substantially flat, light-sensitive element of a light-sensitive receiver. The receiver consists of several pixels in the form of a grid in the line direction and the space direction. In a test phase at least one actual image is generated that is compared with at least one desired image which was produced in a read-in phase. To produce an image of the surface with more information the invention provides that during the read-in phase and/or the test phase at least two images of the surface are taken and the image of the surface which is projected on the light-sensitive element is displaced by at least a fraction of the dimension of a pixel in each case in at least one direction with respect to the light-sensitive element.

Abstract: A process and device for the optical testing of a surface in which the surface can be illuminated substantially from above by at least one upper light and from the side by at least one lower light, at a sharp angle with respect to the surface. The light reflected and/or scattered by the surface is recorded in a test period by at least one light-sensitive receiver and at least one actual image which is compared with at least one desired image is produced. To permit an improved test provision is made for the surface to be recorded by the light-sensitive receiver at least twice during the test period. During the recording periods in question the surface is illuminated by an at least intermittent illumination from above and/or from the side in a different manner in order to obtain at least two actual images with different illumination of the surface.