Abstract: A roofing shingle includes a top sheet having a headlap and a plurality of tabs extending from the headlap. Each tab has an upper portion, a lower portion, an intermediate portion between the upper and lower portions, and a first plurality of granules having a first color located in the upper portion of at least one tab. The first plurality of granules comprises antimicrobial granules. Each tab has a second plurality of granules having a second color located in the lower portion of the at least one tab and a third plurality of granules having a third color located in the intermediate portion of the at least one tab. The first color and the second color are darker than the third color. A back sheet is attached to the top sheet and underlies the tabs such that the back sheet has an exposed front surface between each of the tabs.

Abstract: A roofing shingle for installation as part of a roofing structure includes at least one layer of a shingle material having a top surface and a bottom surface. The roofing single will include a headlap portion and an exposure portion having a plurality of tabs with a plurality of granules being applied along the top surface. Shadow lines are defined at selected locations along the top surface of the roofing shingle to provide the roofing shingles with a selected visual appearance.

Abstract: A roofing shingle for installation as part of a roofing structure includes at least one layer of a shingle material having a top surface and a bottom surface. The roofing single will include a headlap portion and an exposure portion having a plurality of tabs with a plurality of granules being applied along the top surface. Shadow lines are defined at selected locations along the top surface of the roofing shingle to provide the roofing shingles with a selected visual appearance.

Abstract: Relates to a compound of Formula I a salt, hydrate, solvate, tautomer, enantiomer, racemate, diastereomer, or combination thereof. Also, relates to a compound of Formula II a salt, hydrate, solvate, tautomer, enantiomer, racemate, diastereomer, or combination thereof. The compounds can be a matrix metalloproteinase (MMP) inhibitor. The compounds can also treat a matrix metalloproteinase mediated condition such as cancer.

Abstract: An apparatus for stretching and strengthening extremities includes a foot placement foundation having an inversion plane, a neutral plane, and an eversion plane. Support elements for the foot placement foundation include a front element, a back element, and two side elements connecting the front element to the back element, where the front element is shorter than the back element, forming an incline in the foot placement foundation. The foot placement foundation can have an incline of 15 or 20 degrees from horizontal, the apparatus can include an adjustment mechanism used to modify the incline in the foot placement foundation, and the side elements can be wedge-shaped. In addition, the front, back, and side elements can together include a flat bottom.

Abstract: An apparatus for stretching and strengthening extremities includes a foot placement foundation having an inversion plane, a neutral plane, and an eversion plane. A selectively actuatable adjustment mechanism is connected to the foot placement foundation to permit a user of the apparatus to adjust the incline of the foot placement foundation as desired.

Abstract: An apparatus for stretching and strengthening extremities includes a foot placement foundation having an inversion plane, a neutral plane, and an eversion plane. A selectively actuatable adjustment mechanism is connected to the foot placement foundation to permit a user of the apparatus to adjust the incline of the foot placement foundation as desired.