Patents by Inventor Bryan Hoglund

Bryan Hoglund has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutation in the epidermal growth factor receptor kinase domain
    Patent number: 9994914
    Abstract: A new in-frame deletion was found in exon 19 of the EGFR gene, the exon that is often mutated in tumors. The invention comprises methods of detecting the mutation, methods of prognosis and methods of predicting response to treatment based on the presence of absence of the mutation.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: June 12, 2018
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Bryan Hoglund, Janet Jin, Yan Li, Wei-Min Liu
  • Non-invasive early detection of solid organ transplant rejection by quantitative analysis of mixtures by deep sequencing of HLA gene amplicons using next generation systems
    Patent number: 9752189
    Abstract: The invention is a method of detecting or assessing solid organ graft (transplant) rejection by detecting donor-specific HLA alleles in a blood sample of a graft (transplant) recipient. The invention further comprises a method of detecting the presence of maternal cells in a blood sample of an offspring.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: September 5, 2017
    Assignees: Roche Molecular Systems, Inc., The Scripps Research Institute
    Inventors: Henry Erlich, Bryan Hoglund, Cherie Holcomb, Priscilla Moonsamy, Nick Newton, Melinda Rastrou, Nancy Schoenbrunner, Alison Tsan, Daniel Salomon
  • NOVEL MUTATION IN THE EPIDERMAL GROWTH FACTOR RECEPTOR KINASE DOMAIN
    Publication number: 20170067114
    Abstract: A new in-frame deletion was found in exon 19 of the EGFR gene, the exon that is often mutated in tumors. The invention comprises methods of detecting the mutation, methods of prognosis and methods of predicting response to treatment based on the presence of absence of the mutation.
    Type: Application
    Filed: October 2, 2015
    Publication date: March 9, 2017
    Inventors: Bryan Hoglund, Janet Jin, Yan Li, Wei-Min Liu
  • NON-INVASIVE EARLY DETECTION OF SOLID ORGAN TRANSPLANT REJECTION BY QUANTITATIVE ANALYSIS OF HLA GENE AMPLICONS
    Publication number: 20160017421
    Abstract: The invention is a method of detecting or assessing solid organ graft (transplant) rejection and acute dysfunction—no rejection condition by detecting donor-specific HLA alleles in a blood sample of a graft (transplant) recipient.
    Type: Application
    Filed: November 3, 2014
    Publication date: January 21, 2016
    Inventors: Henry Erlich, Bryan Hoglund, Cherie Holcomb, Priscilla Moonsamy, Nick Newton, Melinda Rastrou, Daniel Salomon, Nancy Shoenbrunner, Alison Tsan
  • METHOD OF DETERMINING THE FRACTION OF FETAL DNA IN MATERNAL BLOOD USING HLA MARKERS
    Publication number: 20150203914
    Abstract: The invention comprises a method of determining the fraction of fetal DNA in maternal blood or plasma using HLA locus wherein the maternal and fetal HLA alleles are detected and quantified by clonal or digital methods.
    Type: Application
    Filed: May 9, 2014
    Publication date: July 23, 2015
    Applicant: Roche Molecular Systems
    Inventors: Henry Erlich, Bryan Hoglund, Cherie Holcomb, Priscilla Moonsamy, Nick Newton, Melinda Rastrou, Nancy Schoenbrunner, Alison Tsan
  • NON-INVASIVE EARLY DETECTION OF SOLID ORGAN TRANSPLANT REJECTION BY QUANTITATIVE ANALYSIS OF MIXTURES BY DEEP SEQUENCING OF HLA GENE AMPLICONS USING NEXT GENERATION SYSTEMS
    Publication number: 20140336056
    Abstract: The invention is a method of detecting or assessing solid organ graft (transplant) rejection by detecting donor-specific HLA alleles in a blood sample of a graft (transplant) recipient. The invention further comprises a method of detecting the presence of maternal cells in a blood sample of an offspring.
    Type: Application
    Filed: May 8, 2014
    Publication date: November 13, 2014
    Applicants: Roche Molecular Systems, The Scripps Research Institute
    Inventors: Henry Erlich, Bryan Hoglund, Cherie Holcomb, Priscilla Moonsamy, Nick Newton, Melinda Rastrou, Nancy Schoenbrunner, Alison Tsan, Daniel Salomon
  • Methods and Compositions for Very High Resolution Genotyping of HLA
    Publication number: 20140141436
    Abstract: The invention is a method of determining HLA genotype for HLA-A, HLA-B, HLA-C, DQB1, DRB1, DRB3, DRB4, DRB5, DPA1 and DPB1. Reagents and kits are also disclosed.
    Type: Application
    Filed: August 21, 2013
    Publication date: May 22, 2014
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Henry Erlich, Bryan Hoglund, Cherie Holcomb, Priscilla Moonsamy